NOAEL Studies
Cosmetic Ingredient
CI 14270 NOAEL Studies
CAS: 1934-21-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 53 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 26:179-187 |
| COSMOS DB | LOAEL | 792 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; CAP |
| COSMOS DB | LOAEL | 8919 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 26:189-194 |
| COSMOS DB | NOAEL | 7.5 | mg/kg bw/day | rat | oral | 322 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 15 | mg/kg bw/day | rat | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 125 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 750 | mg/kg bw/day | rat | oral | 448 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 773 | mg/kg bw/day | mouse | oral | 117 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 984 | mg/kg bw/day | rat | oral | 798 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rabbit | oral | 29 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1064 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1105 | mg/kg bw/day | rat | oral | 798 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | dog | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2190 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2418 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 26:189-194 |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2641 | mg/kg bw/day | rat | oral | 875 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2995 | mg/kg bw/day | rat | oral | 875 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 8919 | mg/kg bw/day | mouse | oral | 728 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =984 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA FEEDAP - 2016 - OutputID 2877 - body weight - systemic - Safety and efficacy of tartrazine (E 102) for cats and dogs, ornamental fish, grain-eating ornamental birds and small rodents - doi:10.2903/j.efsa.2016.4613 |
| EFSA | ADI | <=7.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2009 - OutputID 395 - Consumers - Scientific Opinion on the re-evaluation Tartrazine (E 102) - doi:10.2903/j.efsa.2009.1331 |
| EFSA | ADI | <=10 | mg/kg bw/day | Consumers | - | - | ADI | EFSA FEEDAP - 2016 - OutputID 2877 - Consumers - Safety and efficacy of tartrazine (E 102) for cats and dogs, ornamental fish, grain-eating ornamental birds and small rodents - doi:10.2903/j.efsa.2016.4613 |
| EFSA | NOAEL | =984 | mg/kg bw/day | Rat | oral | - | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of tartrazine (E 102) for cats and dogs, ornamental fish, grain-eating ornamental birds and small rodents. doi:10.2903/j.efsa.2016.4613.; TITLE=Safety and efficacy of tartrazine (E 102) for cats and dogs, ornamental fish, grain-eating ornamental birds and small rodents; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4613; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614315:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe32cf62c832f1e188a080db8809f56d |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_3747; row=2223; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Yellow 5; preferred_name=C.I. Acid Yellow 23; dtxsid=DTXSID1021455; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021455; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=6066; RecordID=ARPathway2016_966; DatasetName=ARPathway2016; DTXSID=DTXSID1021455; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021455 |
SCCNFP Opinion 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | >0.7 | % | rat | oral | chronic | reproductive toxicity | p.13 |
| SCCNFP Opinion | NOAEL | =5 | % | - | dermal | Sub-chronic | repeated dose toxicity | p.7 |
| SCCNFP Opinion | NOAEL | >1000 | mg/kg/day | rat | oral | - | NOAEL study | p.13 |
| SCCNFP Opinion | NOAEL | =2640 | mg/kg | rat | oral | - | carcinogenicity | Ref.: 29 Human studies No data, p.20 |
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =642.8 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe8e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12236?documentUUID=99b7317c-4c1d-4b46-8d69-c269b8cd8271; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15823761:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f990f0ddca26e31dd96603920220ed45 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bcdb6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/9/3?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15824572:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b9437c9f52475c77b2675505c66d1b21 |
| ECHA | NOAEL | =1064 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bcdb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/9/3?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823302_15823343:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31cdf1d175831e0e3bce3de833ef6a4b |
| ECHA | NOAEL | =1064.3 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe90; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12236?documentUUID=99b7317c-4c1d-4b46-8d69-c269b8cd8271; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: changes in number of pregnant|maternal: clinical signs|maternal: food consumption and compound intake|maternal: mortality|maternal: pre and post implantation loss|maternal: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823302_15823343:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1edf34afb222063908f415489ca46971 |
| ECHA | NOAEL | =1250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5f48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21583/7/6/2?documentUUID=2f5ce440-67ff-4f67-a435-888350d4c19d; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847799_15848283:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fa18304b6f5bf0ef89424b9781fedd3d |
| ECHA | NOAEL | =2641 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b387d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/8?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15820383:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0592eab777ba369fc6e978bc7961092 |
| ECHA | NOAEL | =3348 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b387d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/8?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15820384:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f2c3eb756df9b8c8bbeb294b2bfacf42 |
| ECHA | NOAEL | ~8103 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5dd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/6/2?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15849247:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06ff5fa8b4da37951b65c9005c1c4445 |
| ECHA | NOAEL | ~9735 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5dd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17292/7/6/2?documentUUID=34708cf7-8ebc-470f-9040-e36782cd74af; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15849248:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_101a8342e47c02be8159bed1898de8d4 |
ToxValDB ECOTOX 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | % | Rat | oral | subchronic; 49 days | subchronic | LONG_REF=J. Toxicol. Environ. Health2(5): 1211-1220 Sobotka,T.J., R.E. Brodie, and S.L. Spaid Tartrazine and the Developing Nervous System of Rats 1977; TITLE=Tartrazine and the Developing Nervous System of Rats; AUTHOR=Sobotka,T.J., R.E. Brodie, and S.L. Spaid; DOI=10.1080/15287397709529519; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76050; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15610471:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b00bea42e7d9e86daa0bd0afc086ff24 |
| ToxValDB ECOTOX | LOEL | =2 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=J. Toxicol. Environ. Health2(5): 1211-1220 Sobotka,T.J., R.E. Brodie, and S.L. Spaid Tartrazine and the Developing Nervous System of Rats 1977; TITLE=Tartrazine and the Developing Nervous System of Rats; AUTHOR=Sobotka,T.J., R.E. Brodie, and S.L. Spaid; DOI=10.1080/15287397709529519; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76050; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Biochemistry: Hemoglobin|Cell(s): Red blood cell|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599257_15599258:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b7095d46c5bdae73100730cf9181839b |
| ToxValDB ECOTOX | LOEL | =2.5 | % w/v | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.25(12): 891-896 Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat 1987; TITLE=Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat; AUTHOR=Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu; DOI=10.1016/0278-6915(87)90281-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76017; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603926_15603927:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2fe6e24d41f99ef73e369e158f6c34e4 |
| ToxValDB ECOTOX | LOEL | =5 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=J. Nutr.107(5): 822-828 Ershoff,B.H. Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6) 1977; TITLE=Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6); AUTHOR=Ershoff,B.H.; DOI=10.1093/jn/107.5.822; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76051; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600716_15605647_15605648_15609604:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=914578f5440ebf73ad00347aea5ec93b |
| ToxValDB ECOTOX | LOEL | =7.5 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=J. Nutr.107(5): 822-828 Ershoff,B.H. Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6) 1977; TITLE=Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6); AUTHOR=Ershoff,B.H.; DOI=10.1093/jn/107.5.822; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76051; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600716_15605647_15605648_15609604:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d8db789dab10e149e31320e34ae86bde |
| ToxValDB ECOTOX | LOEL | =10 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604354_15604355:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b8f02a3881caf993744eb1f84e658299 |
| ToxValDB ECOTOX | LOEL | =100 | ppm | Rat | injection | chronic; 273.96 days | chronic | LONG_REF=- | Cytobios62(249): 111-117 Giri,A.K., S.K. Das, G. Talukder, and A. Sharma Sister Chromatid Exchange and Chromosome Aberrations Induced by Curcumin and Tartrazine on Mammalian Cells In Vivo 1990; TITLE=Sister Chromatid Exchange and Chromosome Aberrations Induced by Curcumin and Tartrazine on Mammalian Cells In Vivo; AUTHOR=Giri,A.K., S.K. Das, G. Talukder, and A. Sharma; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76048; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations, sister chromatid exchanges; STUDY_GROUP=ECOTOX:15613440:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=2a9c05c71a1b0af9d8a894e5c48e751b |
| ToxValDB ECOTOX | LOEL | =589 | mg/kg bw/day | Rat | oral | chronic; 114 weeks | chronic | LONG_REF=- | Food Chem. Toxicol.26(3): 179-187 Borzelleca,J.F., and J.B. Hallagan Chronic Toxicity/Carcinogenicity Studies of FD & C Yellow No. 5 (Tartrazine) in Rats 1988; TITLE=Chronic Toxicity/Carcinogenicity Studies of FD & C Yellow No. 5 (Tartrazine) in Rats; AUTHOR=Borzelleca,J.F., and J.B. Hallagan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613109:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=04969d91ae29fa0491f61e689329cd11 |
| ToxValDB ECOTOX | NOEL | =1 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=J. Toxicol. Environ. Health2(5): 1211-1220 Sobotka,T.J., R.E. Brodie, and S.L. Spaid Tartrazine and the Developing Nervous System of Rats 1977; TITLE=Tartrazine and the Developing Nervous System of Rats; AUTHOR=Sobotka,T.J., R.E. Brodie, and S.L. Spaid; DOI=10.1080/15287397709529519; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76050; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Biochemistry: Hemoglobin|Cell(s): Red blood cell|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599257_15599258:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0e797c201d47be218f7a805984c9d084 |
| ToxValDB ECOTOX | NOEL | =1 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604354_15604355:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=993f6a691d6ea110a7cfb077008c075b |
| ToxValDB ECOTOX | NOEL | =1.25 | % w/v | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.25(12): 891-896 Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat 1987; TITLE=Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat; AUTHOR=Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu; DOI=10.1016/0278-6915(87)90281-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76017; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603926_15603927:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8f505f81798a68a4b3dc8217732fe2b3 |
| ToxValDB ECOTOX | NOEL | =2 | % w/v | Rat | oral | chronic; 784 days | chronic | LONG_REF=Food Chem. Toxicol.25(12): 891-896 Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat 1987; TITLE=Lack of Carcinogenicity of Tartrazine (FD and C Yellow No. 5) in the F344 Rat; AUTHOR=Maekawa,A., C. Matsuoka, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, J.J. Jang, Y. Hayashi, and T. Ogiu; DOI=10.1016/0278-6915(87)90281-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76017; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Injury: Malignant tumor; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15599964:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=61a5c1019f05d253b644edf03cbb5e4d |
| ToxValDB ECOTOX | NOEL | =2 | % | Rat | oral | short-term; 14 days | developmental | LONG_REF=J. Toxicol. Environ. Health2(5): 1211-1220 Sobotka,T.J., R.E. Brodie, and S.L. Spaid Tartrazine and the Developing Nervous System of Rats 1977; TITLE=Tartrazine and the Developing Nervous System of Rats; AUTHOR=Sobotka,T.J., R.E. Brodie, and S.L. Spaid; DOI=10.1080/15287397709529519; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76050; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Development: Eye opening|Physiology: Neuroresponse|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=development|neurobehavior|reproduction; STUDY_GROUP=ECOTOX:15600386:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db305996467c867493de981fb476a038 |
| ToxValDB ECOTOX | NOEL | =2.5 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=J. Nutr.107(5): 822-828 Ershoff,B.H. Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6) 1977; TITLE=Effects of Diet on Growth and Survival of Rats Fed Toxic Levels of Tartrazine (FD & C Yellow No. 5) and Sunset Yellow FCF (FD & C Yellow No. 6); AUTHOR=Ershoff,B.H.; DOI=10.1093/jn/107.5.822; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76051; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600716_15605647_15605648_15609604:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a996366425a33816110716bb8bef37d1 |
| ToxValDB ECOTOX | NOEL | =1064.32 | mg/L | Rat | oral | short-term; 20 days | developmental | LONG_REF=Food Chem. Toxicol.30(4): 263-268 Collins,T.F.X., T.N. Black, M.W.,Jr. O\'Donnell, and P. Bulhack Study of the Teratogenic Potential of FD & C Yellow No. 5 when Given in Drinking-Water 1992; TITLE=Study of the Teratogenic Potential of FD & C Yellow No. 5 when Given in Drinking-Water; AUTHOR=Collins,T.F.X., T.N. Black, M.W.,Jr. O\'Donnell, and P. Bulhack; DOI=10.1016/0278-6915(92)90002-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76022; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Development: Abnormal|Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=development|food and/or water consumption; STUDY_GROUP=ECOTOX:15601661:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=20f098e5b2fcd31ab29225d3acc6e1a9 |
| ToxValDB ECOTOX | NOEL | =1499.06 | mg/kg bw/day | Mouse | oral | chronic; 730.56 days | chronic | LONG_REF=- | Food Chem. Toxicol.26(3): 189-194 Borzelleca,J.F., and J.B. Hallagan A Chronic Toxicity/Carcinogenicity Study of FD & C Yellow No. 5 (Tartrazine) in Mice 1988; TITLE=A Chronic Toxicity/Carcinogenicity Study of FD & C Yellow No. 5 (Tartrazine) in Mice; AUTHOR=Borzelleca,J.F., and J.B. Hallagan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76019; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Mortality: Survival| Haematological parameters: lesions; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|multiple; STUDY_GROUP=ECOTOX:15613428:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=43943059a553d4739211a498a379c323 |
| ToxValDB ECOTOX | NOEL | =1800.97 | mg/kg bw/day | Mouse | oral | chronic; 730.56 days | chronic | LONG_REF=- | Food Chem. Toxicol.26(3): 189-194 Borzelleca,J.F., and J.B. Hallagan A Chronic Toxicity/Carcinogenicity Study of FD & C Yellow No. 5 (Tartrazine) in Mice 1988; TITLE=A Chronic Toxicity/Carcinogenicity Study of FD & C Yellow No. 5 (Tartrazine) in Mice; AUTHOR=Borzelleca,J.F., and J.B. Hallagan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76019; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Mortality: Survival| Haematological parameters: lesions; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|multiple; STUDY_GROUP=ECOTOX:15613130:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=fdf57dc05da3db642abe775dfbf6bab6 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =372.52 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635049:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3de98b8eb39513e5c6944260e30c878 |
ToxValDB HPVIS 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =5 | % diet | Rat | oral | chronic; 113 weeks | chronic | LONG_REF=Borzelleca J. and Hallagan J. (1988a) A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats. Fd Chem Toxic 26, 179-187.; TITLE=A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats; AUTHOR=Borzelleca J. and Hallagan J; QUALITY=1; EXTERNAL_SOURCE_ID=62461; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15639301:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b62e7008da20ce55ffd8f6c4f608e15 |
| ToxValDB HPVIS | NOAEL | =2641 | mg/kg bw/day | Rat | oral | chronic; 114 weeks | reproduction developmental | LONG_REF=Borzelleca J. and Hallagan J. (1988a) A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats. Fd Chem Toxic 26, 179-187.; TITLE=A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats; AUTHOR=Borzelleca J. and Hallagan J; QUALITY=1; EXTERNAL_SOURCE_ID=65358; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15643187:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c501a85c6c23e3a024ac82e354894851 |
| ToxValDB HPVIS | NOAEL | =3348 | mg/kg bw/day | Rat | oral | chronic; 114 weeks | reproduction developmental | LONG_REF=Borzelleca J. and Hallagan J. (1988a) A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats. Fd Chem Toxic 26, 179-187.; TITLE=A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in rats; AUTHOR=Borzelleca J. and Hallagan J; QUALITY=1; EXTERNAL_SOURCE_ID=65359; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15643188:M:-paternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c3b355d90b659024fa3440a19a059cba |
| ToxValDB HPVIS | NOAEL | =8103 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | LONG_REF=Borzelleca J. and Hallagan J. (1988b) A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in mice. Fd Chem Toxic 26, 189-194.; TITLE=A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in mice; AUTHOR=Borzelleca J. and Hallagan J; QUALITY=1; EXTERNAL_SOURCE_ID=61453; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15640245:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_72df1355ad833ccc1e011e18fe24d8b6 |
| ToxValDB HPVIS | NOAEL | =9753 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | LONG_REF=Borzelleca J. and Hallagan J. (1988b) A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in mice. Fd Chem Toxic 26, 189-194.; TITLE=A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (Tartazine) in mice; AUTHOR=Borzelleca J. and Hallagan J; QUALITY=1; EXTERNAL_SOURCE_ID=61454; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15640246:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d1ae46de0df7e480f0098dd58969568c |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | <=10 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afc40e4b0d99f5a87c0aa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/477; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=WHO JECFA ADI:15715372:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb5e3cc371b5dc63568bd12ef5df6f10 |
Regulatory source 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | >1000 | mg/kg/day | rat | oral | - | - | p.13 |
| Regulatory source | carcinogenicity | 5 | % | rat | oral | - | carcinogenicity | p.20 |
| Regulatory source | carcinogenicity | =2640 | mg/kg | rat | oral | - | carcinogenicity | p.20 |
| Regulatory source | repeated dose toxicity | 5 | % | - | dermal | Sub-chronic | repeated dose toxicity | p.7 |
| Regulatory source | repeated dose toxicity | 5 | % | rabbit | dermal | Sub-chronic | repeated dose toxicity | p.7 |
| Regulatory source | reproductive toxicity | >0.7 | % | rat | oral | chronic | reproductive toxicity | p.13 |
| Regulatory source | reproductive toxicity | 5 | % | rat | oral | 2 months | reproductive toxicity | p.13 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | I753WB2F1M | UNII | - | - | - | chemical | - |