Good Cosmetic Ingredient NOAEL Data

CI 14270

CAS Number
1934-21-0
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Safety Rating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for CI 14270. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 750 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 750 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 1500 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 2641 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 984 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Chronic COSMOS_DB

Expert Verdict

Known allergen especially in aspirin-sensitive individuals with cross-reactivity to aspirin; classified as GHS skin and respiratory sensitizer; requires batch certification in US.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen colorant eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is CI 14270 safe in cosmetics?

Known allergen especially in aspirin-sensitive individuals with cross-reactivity to aspirin; classified as GHS skin and respiratory sensitizer; requires batch certification in US. The EU classifies CI 14270 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is CI 14270 allowed in the EU?

CI 14270 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 14270 do in cosmetics?

CI 14270 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 1934-21-0.

What is the Margin of Safety for CI 14270?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 14270?

The NOAEL (No Observed Adverse Effect Level) for CI 14270 is 750 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check CI 14270 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Acid Blue 1
Poor
Methylimidazoliumpropyl p-Phenylenediamine HCl
Moderate
2-Amino-5-Ethylphenol HCl
Moderate
Solvent Green 3
Good
HC Yellow No. 7
Moderate
Browse all 30,000+ ingredients →
📱

Is CI 14270 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 14270 in your formulation.

Ingredient Decoder MoS Calculator