NOAEL Studies Cosmetic Ingredient

CI 61570 NOAEL Studies

CAS: 4403-90-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 91 day Subchronic SCCP; Hamann, H.-J. et al. (2000): D&C Green 5 (CI 61750): 13-week oral toxicity (gavage)study in rats. Project n° 740687, RCC Ltd, Switzerland
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >3160 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6512; row=4137; data_type=In Vivo; mixture=Chemical; chemical_name=D&C Green 5; preferred_name=Benzenesulfonic acid, 2,2'-[(9,10-dihydro-9,10-dioxo-1,4-anthracenediyl)diimino]bis[5-methyl-, sodium salt (1:2); dtxsid=DTXSID2024903; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024903; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2024903; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6513; row=4138; data_type=In Vivo; mixture=Chemical; chemical_name=D&C Green 5; preferred_name=Benzenesulfonic acid, 2,2'-[(9,10-dihydro-9,10-dioxo-1,4-anthracenediyl)diimino]bis[5-methyl-, sodium salt (1:2); dtxsid=DTXSID2024903; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024903; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2024903; source_file=acute_oral.xlsx
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0004 mg/kg bw/d rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =48 mg/kg bw/d rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =95 % - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =95 mg/kg bw/d rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =100 mg/kg bw/day - - Chronic genotoxicity p.13
SCCS Opinion NOAEL =100 mg/kg bw/day rat - - NOAEL study Ref.: 4 (subm I, p.17
SCCS Opinion NOAEL =300 mg/kg bw/day human - developmental developmental toxicity Ref.: 17 (subm I, updated) 3, p.22
SCCS Opinion NOAEL =1000 mg/kg bw/day human - developmental developmental toxicity Ref.: 17 (subm I, updated) 3, p.22
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba28f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17364/7/9/2?documentUUID=953196e5-a1b2-436d-adf1-42193f710c0c; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15861680:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f51bc7cee563577c1d42280a57d146bc
Regulatory source 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day rat - - - p.17
Regulatory source dermal absorption =0.0004 mg/kg bw/d rat oral 90-day dermal absorption p.23
Regulatory source dermal absorption =48 mg/kg bw/d rat oral 90-day dermal absorption p.23
Regulatory source dermal absorption =95 mg/kg bw/d rat oral 90-day dermal absorption p.23
Regulatory source developmental toxicity 100 mg/kg bw/day rat oral 13 week developmental toxicity p.23
Regulatory source developmental toxicity 300 mg/kg bw/day human - developmental developmental toxicity p.22
Regulatory source developmental toxicity 300 mg/kg bw/day rat oral 13 week developmental toxicity p.23
Regulatory source developmental toxicity 1000 mg/kg bw/day human - developmental developmental toxicity p.22
Regulatory source developmental toxicity 1000 mg/kg bw/day rat oral 13 week developmental toxicity p.23
Regulatory source genotoxicity 95 % - - Chronic genotoxicity p.18
Regulatory source genotoxicity 100 mg/kg bw/day - - Chronic genotoxicity p.13
Regulatory source genotoxicity 100 mg/kg bw/day rat oral 13 week genotoxicity p.16
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8J6RDU8L9X UNII - - - chemical -