NOAEL Studies Cosmetic Ingredient

CI 62045 NOAEL Studies

CAS: 4368-56-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCP; C. Fabreguettes. Thirteen-Week Toxicity Study by Oral Route (Gavage) in Rats. CITStudy No. 10604 TSR (CIES1 93045), October 17, 1994
COSMOS DB LOAEL 300 mg/kg bw/day rat oral 6-15 Gestation day Developmental SCCP; M.H. Savary. Embryotoxicity/Teratogenicity Study by Oral Route in Rats. CIT Study No.10637 RSR (CIES1 94001), January 12, 1994
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =53 % mouse oral developmental repeated dose toxicity p.18
SCCNFP Opinion NOAEL =300 mg/kg bw/day rat - - developmental toxicity p.14
SCCS Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =160 mg/kg rat oral subchronic repeated dose toxicity p.22
SCCS Opinion NOAEL =300 mg/kg bw/day rat - - developmental toxicity p.21
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 300 mg/kg bw/day rat - - developmental toxicity p.14
Regulatory source repeated dose toxicity 53 % mouse oral developmental repeated dose toxicity p.18
Regulatory source repeated dose toxicity =160 mg/kg rat oral subchronic repeated dose toxicity p.22
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier DG356U29IU UNII - - - chemical -