Good Cosmetic Ingredient NOAEL Data

CI 62045

CAS Number
4368-56-3
Function
Dye
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not listed as an FDA-certified color additive for cosmetics in the US; EU-permitted in rinse-off / brief skin-contact products only (Annex IV/94; field of application 4)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for CI 62045. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 300 mg/kg bw/day oral rat Developmental COSMOS_DB

Expert Verdict

EU-restricted blue anthraquinone dye (Acid Blue 62) limited to brief skin-contact and rinse-off cosmetics; SCCP assessed; not FDA-certified in the US; low concern when used within EU restrictions

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Concern Level: Low

Regulatory Flags

rinse-off-only brief-contact-only not-fda-approved anthraquinone eu_cosing_listed

Frequently Asked Questions

Is CI 62045 safe in cosmetics?

EU-restricted blue anthraquinone dye (Acid Blue 62) limited to brief skin-contact and rinse-off cosmetics; SCCP assessed; not FDA-certified in the US; low concern when used within EU restrictions The EU classifies CI 62045 as "restricted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is CI 62045 allowed in the EU?

CI 62045 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 62045 do in cosmetics?

CI 62045 functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 4368-56-3.

What is the Margin of Safety for CI 62045?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 62045?

The NOAEL (No Observed Adverse Effect Level) for CI 62045 is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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