NOAEL Studies Colorant

Carbon Black NOAEL Studies

INCI: CI 77266

CAS: 1333-86-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 2003-02-21 California Proposition 65 listing -
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 2006 IARC Monographs -
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 2 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=8445; Record_ID=cancer_6638; Data_Type=WOE; Formulation_Name=Carbon black; Mixture=Chemical; DTXSID=DTXSID7051216; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/83; http://publications.iarc.fr/111; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051216
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0 mg/kg bw/d rat oral developmental developmental toxicity Ref.: Ramesh (2012), p.85
SCCS Opinion NOAEL =1 - rat - subchronic repeated dose toxicity p.38
SCCS Opinion NOAEL =7 - rat - 13 weeks NOAEL study Ref.: Elder et al, p.38
SCCS Opinion NOAEL =38 - rat - - NOAEL study p.38
SCCS Opinion NOAEL =1000 mg/kg/day rat oral 13 weeks NOAEL study Ref.: Sathish, 2012, p.33
SCCS Opinion NOAEL =1000 mg/kg bw/d rat oral 11 months genotoxicity p.95
SCCS Opinion NOAEL =1515 - rat inhalation 11 months carcinogenicity p.39
ECHA 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =1000 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/3/2?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15811963:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66d6739aaef6405270883372de0c94d8
ECHA LOAEC =2.5 mg/m3 Rat inhalation chronic; 24 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15829026:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65db862b7f92c3ef16db3e9a8ba238e6
ECHA LOAEC =6 mg/m3 Rat inhalation subchronic; 2 months subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15828248:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d637ae2ed9518c6a53164ddfca09f9c6
ECHA LOAEL =11 mg/m3 Rat inhalation subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15828929:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21cb7a28e94eafb73d86afb4acbf3334
ECHA LOEC >=1.55 mg/m3 Hamster inhalation subchronic; 53 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829665_15829666:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6365bb3e0ec031daba9ef836e66969aa
ECHA LOEC <=1.56 mg/m3 Hamster inhalation subchronic; 53 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829665_15829666:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb5451c72f4f6aafc339370ee11960a3
ECHA LOEC =9.08 mg/m3 Rat inhalation short-term; 3 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827404_15827405:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0f103cb3917bc08d861ef03b523bf10
ECHA NOAEC >=1.1 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829641_15829642_15829643_15829644_15829645_15829646:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e2d0bc0165d739e092cc83ef72b54ea
ECHA NOAEC >=2.5 mg/m3 Rat inhalation acute; 16 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829633_15829634:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4334a693d25319cf9dc85d386c286f1
ECHA NOAEC >=7.1 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829641_15829642_15829643_15829644_15829645_15829646:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1a35b96e81bdc128b136c80534ae188
ECHA NOAEC >=7.4 mg/m3 Mouse inhalation chronic; 10 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829625_15829626:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_519b9a5adc2b903494ca5cc1a206342d
ECHA NOAEC >=52.8 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829641_15829642_15829643_15829644_15829645_15829646:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_22f5210b9ccce0c6b4d156ef13290e62
ECHA NOAEC >34000 mg/m3 Mouse inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bce4b0a7c65d219dc3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/9/2?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID:15860273:M:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_52f9064a866afe365f65ae88a503330e
ECHA NOEC =9.83 mg/m3 Rat inhalation short-term; 3 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/6/3?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827404_15827405:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76da124d5fcbb5648431c09a03b51b5a
ECHA NOEC =34 mg/m3 Mouse inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bce4b0a7c65d219dc3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24448/7/9/2?documentUUID=78da8852-ad83-4e3e-a7e7-e05caf013b6c; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855702_15856470:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_726ec19806f2424f0649197ecc55ff67
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630579:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a94e8e43b0adc0e9bdb4bd10efd9b0c0
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 7 - rat - 13 weeks - p.38
Regulatory source - 38 - rat - - - p.38
Regulatory source - 1000 mg/kg/day rat oral 13 weeks - p.33
Regulatory source - 1000 mg/kg bw/d rat oral chronic - p.92
Regulatory source carcinogenicity 1515 - rat inhalation 11 months carcinogenicity p.39
Regulatory source developmental toxicity 0 mg/kg bw/d rat oral developmental developmental toxicity p.85
Regulatory source genotoxicity 1000 mg/kg bw/d rat oral 11 months genotoxicity p.95
Regulatory source repeated dose toxicity 1 - rat - subchronic repeated dose toxicity p.38
Regulatory source repeated dose toxicity 1000 mg/kg/day rat oral 13-week repeated dose toxicity p.94
Regulatory source reproductive toxicity 0 mg/kg bw/d rat oral developmental reproductive toxicity p.86
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4XYU5U00C4 UNII - - - chemical -