NOAEL Studies
Cosmetic Ingredient
CI 77891 (Titanium Dioxide) NOAEL Studies
INCI: CI 77891
CAS: 13463-67-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1250 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | mouse | oral | 14 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =2250 | mg/kg bw/day | Rat | oral: feed | 721 days | chronic/long term toxicity | EFSA ANS - 2016 - OutputID 2862 - no adverse effect observed at single/highest dose - Re-evaluation of titanium dioxide (E 171) as a food additive - doi:10.2903/j.efsa.2016.4545 |
| EFSA | NOAEL | =2250 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA ANS (2016). Re-evaluation of titanium dioxide (E 171) as a food additive. doi:10.2903/j.efsa.2016.4545.; TITLE=Re-evaluation of titanium dioxide (E 171) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4545; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614211:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc495356b39e06395dc79d96bdffb238 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2006 | IARC Monographs | - |
WHO/JECFA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =250 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v1051je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Ninety-seventh report of the Joint FAO/WHO Expert Committee on Food Additiv; path=mirror/documents/jecfa/jecmono/v1051je01.pdf; row_hash=39e982024cf86cd9; raw_unit=mg/kg bw per day; context=2309), a NOAEL of 250 mg/kg bw per day for the two structurally related substances - γ-nonalactone (No. |
| WHO/JECFA | NOAEL | =260 | mg/kg bw/day | Mouse | - | 2-year | Chronic toxicity | document_id=jecfa_jecmono_v1051je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Ninety-seventh report of the Joint FAO/WHO Expert Committee on Food Additiv; path=mirror/documents/jecfa/jecmono/v1051je01.pdf; row_hash=a34ee232ecf03f80; raw_unit=mg/kg bw per day; context=In a 2-year study in mice with γ-butyrolactone, a NOAEL of 260 mg/kg bw per day was established. |
| WHO/JECFA | NOAEL | =1000 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v1051je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Ninety-seventh report of the Joint FAO/WHO Expert Committee on Food Additiv; path=mirror/documents/jecfa/jecmono/v1051je01.pdf; row_hash=dd58e7e06d66ab47; raw_unit=mg/kg bw per day; context=The Committee concluded that the NOAEL was 1000 mg/kg bw per day, the highest dose tested. |
| WHO/JECFA | NOAEL | =1251 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v1051je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Ninety-seventh report of the Joint FAO/WHO Expert Committee on Food Additiv; path=mirror/documents/jecfa/jecmono/v1051je01.pdf; row_hash=f4cd3985972b5abc; raw_unit=mg/kg bw per day; context=2304), the NOAEL of 1251 mg/kg bw per day for the structurally related substance isobutyl alcohol (No. |
NTP ICE acute inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >2.28 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1933; Record_ID=acute_inhalation_1655; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.28; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/3/3/?documentUUID=7386ba32-da5c-4d1d-a6af-48063f531f4a; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
| NTP ICE acute inhalation | LC50 | 3.43 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1930; Record_ID=acute_inhalation_1674; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.43; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/3/3/?documentUUID=71d36a33-638f-45de-8412-46f4192750d7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
| NTP ICE acute inhalation | LC50 | >3.56 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1932; Record_ID=acute_inhalation_1649; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=3.56; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/3/3/?documentUUID=1112c23b-7206-4a11-9a44-f8e8a013adb9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
| NTP ICE acute inhalation | LC50 | 5.09 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1929; Record_ID=acute_inhalation_1657; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.09; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/3/3/?documentUUID=71d36a33-638f-45de-8412-46f4192750d7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
| NTP ICE acute inhalation | LC50 | >6.82 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1931; Record_ID=acute_inhalation_1643; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=6.82; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/3/3/?documentUUID=2fcf00cd-8893-480f-a50b-7d24d91a2df8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3670; Record_ID=cancer_6686; Data_Type=WOE; Formulation_Name=Titanium dioxide; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/111; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
| NTP ICE cancer | Top dose | 50000 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3664; Record_ID=cancer_6682; Data_Type=In Vivo; Formulation_Name=Titanium dioxide; Mixture=Chemical; DTXSID=DTXSID3021352; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-097; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr097/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021352; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021352 |
SCCS Opinion 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.6 | % | rat | oral | developmental | developmental toxicity | p.36 |
| SCCS Opinion | NOAEL | =2 | % | rat | oral | 24 months | reproductive toxicity | p.37 |
| SCCS Opinion | NOAEL | =62.5 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.61 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.36 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | 2023d | repeated dose toxicity | p.37 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 2-year | carcinogenicity | p.38 |
| SCCS Opinion | NOAEL | =1742 | mg/kg bw/day | - | oral | developmental | reproductive toxicity | p.39 |
| SCCS Opinion | NOAEL | =2055 | mg/kg bw/day | rat | oral | 26-month | carcinogenicity | p.38 |
| SCCS Opinion | NOAEL | =100000 | ppm | rat | oral | Subchronic | repeated dose toxicity | Reference: I-NCI, 1979 (22), p.61 |
ECHA 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =10.5 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/6/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827769_15827770:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a7a664d71ee92620287dd98f19fb594 |
| ECHA | LOAEC | =10.8 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/6/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828371_15828372:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c23f527cd08b240cf2ca8826579a0a21 |
| ECHA | NOAEC | =2.1 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/6/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827769_15827770:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3b0f53bd3e2366d266a2692420dedef |
| ECHA | NOAEC | =2.2 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/6/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828371_15828372:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3c7931419d3519cc3a7787fe0fabad5 |
| ECHA | NOAEC | =10.7 | mg/m3 | Hamster | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/6/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15827963:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4601c85f666361db96a11ab237d25bc9 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc2d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15560/7/9/3?documentUUID=3360473e-6431-4bb1-8453-460a7e20d99d; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15824217:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_627303d0f5d63c1f7508b720cf64ab51 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =1000 | ppm | Rat | oral | acute; 0.875 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.9(5): 273-285 Kitchin,K.T., and J.L. Brown Biochemical Studies of Promoters of Carcinogenesis in Rat Liver 1989; TITLE=Biochemical Studies of Promoters of Carcinogenesis in Rat Liver; AUTHOR=Kitchin,K.T., and J.L. Brown; DOI=10.1002/tcm.1770090503; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Cytochrome P-450|Enzyme(s): Ornithine decarboxylase|Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX:15605027:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a3fa52ac689e5b5da6e6b0d6c2a1772 |
| ToxValDB ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15607327:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=046fb9c87e0a4abf520717303dc2140e |
ToxValDB GESTIS DNEL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.17 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635273_15635274_15635275:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b0dd3ec205970e84a2cdb0aa1d31fde0 |
| ToxValDB GESTIS DNEL | DNEL local | =0.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635273_15635274_15635275:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41e790dec87b1d884b0e55fe62af7d49 |
| ToxValDB GESTIS DNEL | DNEL local | =1.25 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635273_15635274_15635275:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83cf42f310bacf42aea2fd41d807f8f3 |
Regulatory source 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | carcinogenicity | 1000 | mg/kg bw/day | rat | oral | 2-year | carcinogenicity | p.38 |
| Regulatory source | carcinogenicity | 2055 | mg/kg bw/day | rat | oral | 26-month | carcinogenicity | p.38 |
| Regulatory source | developmental toxicity | 0.6 | % | rat | oral | developmental | developmental toxicity | p.36 |
| Regulatory source | developmental toxicity | 100 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 62.5 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.61 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/day | rat | oral | 2023d | repeated dose toxicity | p.37 |
| Regulatory source | repeated dose toxicity | 100000 | ppm | rat | oral | Subchronic | repeated dose toxicity | p.61 |
| Regulatory source | repeated dose toxicity | 100000 | ppm | mouse | oral | subchronic | repeated dose toxicity | p.62 |
| Regulatory source | reproductive toxicity | 2 | % | rat | oral | 24 months | reproductive toxicity | p.37 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | oral | prenatal | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 1742 | mg/kg bw/day | - | oral | developmental | reproductive toxicity | p.39 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 15FIX9V2JP | UNII | - | - | - | chemical | - |