CI 77891 (Titanium Dioxide)
INCI: CI 77891
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for CI 77891 (Titanium Dioxide). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
. The CIR Expert Panel concluded that dimethicone is safe in cosmetics in the present practices of use and reported concentration ranges when formulated to be non- irritating, with the exception that the available data are insufficient to make a determination of safety for use in products that
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
Expert Verdict
Broadly permitted and widely used inorganic colorant and UV filter with a strong overall safety profile for dermal use. EU and US both permit topical application. EU applies specific Annex III restrictions on inhalable formats (powders, sprays) to address lung exposure risk. The inhalation carcinogenicity concern (IARC 2B) is route-specific and does not apply to dermal use.
Regulatory Flags
Frequently Asked Questions
Is CI 77891 (Titanium Dioxide) safe in cosmetics?
Broadly permitted and widely used inorganic colorant and UV filter with a strong overall safety profile for dermal use. EU and US both permit topical application. EU applies specific Annex III restrictions on inhalable formats (powders, sprays) to address lung exposure risk. The inhalation carcinogenicity concern (IARC 2B) is route-specific and does not apply to dermal use. The EU classifies CI 77891 (Titanium Dioxide) as "restricted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is CI 77891 (Titanium Dioxide) allowed in the EU?
CI 77891 (Titanium Dioxide) EU regulatory status: restricted. Maximum allowed concentration: 25% as UV filter; 1.4% in hair aerosol sprays for consumers, 1.1% for professional use. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 77891 (Titanium Dioxide) do in cosmetics?
CI 77891 (Titanium Dioxide) functions as: Colorant; UV Filter; Opacifying Agent. Inorganic pigment (TiO2) used as a white colorant and opacity agent in foundations, sunscreens, face powders, eye shadows, lipsticks, and toothpaste. Functions as a physical UV filter in sunscreen formulations. Produced synthetically in anatase or rutile crystal forms.. It is classified as a cosmetic ingredient in our database. CAS number: 13463-67-7.
What is the Margin of Safety for CI 77891 (Titanium Dioxide)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for CI 77891 (Titanium Dioxide)?
The NOAEL (No Observed Adverse Effect Level) for CI 77891 (Titanium Dioxide) is 1250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is CI 77891 (Titanium Dioxide) classified as hazardous under GHS?
CI 77891 (Titanium Dioxide) carries a GHS signal word of "DANGER". Hazard statements: Causes damage to respiratory system through prolonged or repeated exposure if inhaled Suspected of causing cancer. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check CI 77891 (Titanium Dioxide) compliance across multiple jurisdictions:
Related Ingredients
Is CI 77891 (Titanium Dioxide) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 77891 (Titanium Dioxide) in your formulation.