NOAEL Studies Cosmetic Ingredient

CINNAMAL NOAEL Studies

CAS: 104-55-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 25 mg/kg bw/day rat oral 7-17 Gestation day Developmental PAFA; FOOD CHEM TOXICOL 27:781-786
COSMOS DB NOAEL 1.5 mg/kg bw/day rat oral 168 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5 mg/kg bw/day rat oral 7-17 Gestation day Developmental PAFA; FOOD CHEM TOXICOL 27:781-786
COSMOS DB NOAEL 25 mg/kg bw/day rat oral 11 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 68 mg/kg bw/day rat oral 140 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 73.5 mg/kg bw/day rat oral 90 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 90 mg/kg bw/day rat oral 84 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 200 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 270 mg/kg bw/day mouse oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 375 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 570 mg/kg bw/day rat oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 650 mg/kg bw/day mouse oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 940 mg/kg bw/day rat oral 12 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 17 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1200 mg/kg bw/day mouse oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2620 mg/kg bw/day mouse oral 12 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3750 mg/kg bw/day mouse oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =275 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2017 - OutputID 2920 - clinical chemistry - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
NTP ICE acute dermal 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute dermal EPA classification 4 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=521; Record_ID=acute_dermal_556; Data_Type=In Vivo; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE acute dermal GHS classification 5 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=522; Record_ID=acute_dermal_556; Data_Type=In Vivo; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE acute dermal LD50 >5050 mg/kg Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=520; Record_ID=acute_dermal_556; Data_Type=In Vivo; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5050.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE acute inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation EPA Classification 4 unitless - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1019; Record_ID=acute_inhalation_452; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE acute inhalation LC50 2.1 mg/L - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1018; Record_ID=acute_inhalation_452; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.1; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE acute oral 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral EPA classification =3 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13134; row=2635; data_type=In Vivo; mixture=Mixture; formulation_id=MIX549; formulation_name=X-Cide 800 Biocide; chemical_name=Cinnamaldehyde; preferred_name=3-Phenylprop-2-enal; percent_active_ingredient=50.0; dtxsid=DTXSID1024835; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE acute oral GHS classification =5 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13134; row=2636; data_type=In Vivo; mixture=Mixture; formulation_id=MIX549; formulation_name=X-Cide 800 Biocide; chemical_name=Cinnamaldehyde; preferred_name=3-Phenylprop-2-enal; percent_active_ingredient=50.0; dtxsid=DTXSID1024835; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2200 mg/kg bw Rat (Male/Female) oral acute Rat Acute Oral Toxicity Pesticide Active Ingredients Database (undated); record_id=acute_oral_422; row=2631; data_type=In Vivo; mixture=Chemical; chemical_name=3-Phenylprop-2-enal; preferred_name=3-Phenylprop-2-enal; dtxsid=DTXSID1024835; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2220 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_423; row=2632; data_type=In Vivo; mixture=Chemical; chemical_name=3-Phenylprop-2-enal; preferred_name=3-Phenylprop-2-enal; dtxsid=DTXSID1024835; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3129 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13134; row=2634; data_type=In Vivo; mixture=Mixture; formulation_id=MIX549; formulation_name=X-Cide 800 Biocide; chemical_name=Cinnamaldehyde; preferred_name=3-Phenylprop-2-enal; percent_active_ingredient=50.0; dtxsid=DTXSID1024835; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_424; row=2633; data_type=In Vivo; mixture=Chemical; chemical_name=3-Phenylprop-2-enal; preferred_name=3-Phenylprop-2-enal; dtxsid=DTXSID1024835; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024835; source_file=acute_oral.xlsx
NTP ICE eye irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation EPA Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=565; Record_ID=eye_irritation_1189; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID1051; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50.0; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation EPA classification 3 unitless Rabbit Dermal - In Vivo; Draize Skin Irritation/Corrosion Test sheet=Data_invivo; excel_row=403; Record_ID=skin_irritation_invivo_271; Data_Type=In Vivo; Formulation_ID=MIX549; Formulation_Name=X-Cide 800 Biocide; Percent_Active_Ingredient=50; Mixture=Mixture; DTXSID=DTXSID1024835; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 5.63 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=1003; Record_ID=skin_irritation_invitro_264; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=EpiSkin Irritation; Endpoint=Viability; Response=5.63; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 7.49 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=1004; Record_ID=skin_irritation_invitro_265; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7.49; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 10.5 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=997; Record_ID=skin_irritation_invitro_272; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=EpiDerm Irritation; Endpoint=Viability; Response=10.5; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 11 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1005; Record_ID=skin_irritation_invitro_266; Data_Type=In Vitro; Formulation_Name=cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=11; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 11.3 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=1011; Record_ID=skin_irritation_invitro_273; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=EpiDerm Irritation; Endpoint=Viability; Response=11.3; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 12.2 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1006; Record_ID=skin_irritation_invitro_267; Data_Type=In Vitro; Formulation_Name=cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=12.2; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 12.3 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1007; Record_ID=skin_irritation_invitro_268; Data_Type=In Vitro; Formulation_Name=cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=12.3; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 12.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=1012; Record_ID=skin_irritation_invitro_274; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=EpiDerm Irritation; Endpoint=Viability; Response=12.4; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 13.8 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1009; Record_ID=skin_irritation_invitro_270; Data_Type=In Vitro; Formulation_Name=cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=13.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 16 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1010; Record_ID=skin_irritation_invitro_271; Data_Type=In Vitro; Formulation_Name=cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=16; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 21.4 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1013; Record_ID=skin_irritation_invitro_275; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=21.4; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 30.1 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1014; Record_ID=skin_irritation_invitro_276; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=30.1; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability 35.6 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=1015; Record_ID=skin_irritation_invitro_277; Data_Type=In Vitro; Formulation_Name=Cinnamaldehyde; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=35.6; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability (18 hours) 9.5 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=998; Record_ID=skin_irritation_invitro_204; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=9.5; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin irritation Viability (42 hours) 7 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=1001; Record_ID=skin_irritation_invitro_204; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization 167 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 12.3 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2059; Record_ID=skin_sensitization_invitro_513; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=12.3; Reported_Response_Unit=ug/mL; Response=12.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD54, EC200 14.5 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2454; Record_ID=skin_sensitization_invitro_592; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=14.5; Reported_Response_Unit=ug/mL; Response=14.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD54, EC200 14.7 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2459; Record_ID=skin_sensitization_invitro_594; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=14.7; Reported_Response_Unit=ug/mL; Response=14.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD54, EC200 15.7 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2473; Record_ID=skin_sensitization_invitro_596; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=15.7; Reported_Response_Unit=ug/mL; Response=15.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 0.5 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8253; Record_ID=skin_sensitization_invitro_2276; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=3.783292978; Reported_Response_Unit=uM; Conversion_Factor_Value=132.162; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.5; Converted_Response_Unit=ug/mL; Response=0.5; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 1 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8477; Record_ID=skin_sensitization_invitro_2335; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=1; Reported_Response_Unit=ug/mL; Response=1; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 7.5 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2471; Record_ID=skin_sensitization_invitro_596; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=7.5; Reported_Response_Unit=ug/mL; Response=7.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 10.2 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2058; Record_ID=skin_sensitization_invitro_513; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=10.199999999999999; Reported_Response_Unit=ug/mL; Response=10.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 10.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2450; Record_ID=skin_sensitization_invitro_592; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=10.3; Reported_Response_Unit=ug/mL; Response=10.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CD86, EC150 18.8 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2461; Record_ID=skin_sensitization_invitro_594; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=18.8; Reported_Response_Unit=ug/mL; Response=18.8; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV70 8 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8478; Record_ID=skin_sensitization_invitro_2335; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=U-SENS; Endpoint=CV70; Reported_Response=8; Reported_Response_Unit=ug/mL; Response=8; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV75 12.7 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2452; Record_ID=skin_sensitization_invitro_592; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CV75; Reported_Response=12.7; Reported_Response_Unit=ug/mL; Response=12.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV75 28 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2060; Record_ID=skin_sensitization_invitro_513; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CV75; Reported_Response=28; Reported_Response_Unit=ug/mL; Response=28; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV75 31.1 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2476; Record_ID=skin_sensitization_invitro_596; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CV75; Reported_Response=31.1; Reported_Response_Unit=ug/mL; Response=31.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV75 38.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2463; Record_ID=skin_sensitization_invitro_594; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CV75; Reported_Response=38.299999999999898; Reported_Response_Unit=ug/mL; Response=38.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization CV75 54.9 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3846; Record_ID=skin_sensitization_invitro_873; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=h-CLAT; Endpoint=CV75; Reported_Response=54.9; Reported_Response_Unit=ug/mL; Response=54.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.125 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2635; Record_ID=skin_sensitization_invivo_709; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.125; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.2273 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2603; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.2273; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.3125 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2588; Record_ID=skin_sensitization_invivo_700; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.41 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2673; Record_ID=skin_sensitization_invivo_708; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.41; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.625 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2548; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.625; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.05 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2653; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.05; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2566; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.783 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2657; Record_ID=skin_sensitization_invivo_712; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.783; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 2.675 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2643; Record_ID=skin_sensitization_invivo_710; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.675; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 2.75 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2628; Record_ID=skin_sensitization_invivo_707; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.1818 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2599; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.1818; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.2 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2668; Record_ID=skin_sensitization_invivo_708; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.2; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2585; Record_ID=skin_sensitization_invivo_700; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.3333 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2654; Record_ID=skin_sensitization_invivo_712; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.3333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2544; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 0.75 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2649; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Concentration, one positive response 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2561; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Cys 67.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=336; Record_ID=skin_sensitization_invitro_108; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=67.099999999999994; Reported_Response_Unit=%; Response=67.1; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Cys 70.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=329; Record_ID=skin_sensitization_invitro_106; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=70.599999999999994; Reported_Response_Unit=%; Response=70.6; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Cys 77.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=352; Record_ID=skin_sensitization_invitro_112; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=77.5; Reported_Response_Unit=%; Response=77.5; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys 43.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=328; Record_ID=skin_sensitization_invitro_106; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=43.2; Reported_Response_Unit=%; Response=43.2; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys 50.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=334; Record_ID=skin_sensitization_invitro_108; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=50.3; Reported_Response_Unit=%; Response=50.3; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys 64.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=351; Record_ID=skin_sensitization_invitro_112; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=64.7; Reported_Response_Unit=%; Response=64.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys + Cys 56.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=331; Record_ID=skin_sensitization_invitro_106; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=56.9; Reported_Response_Unit=%; Response=56.9; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys + Cys 58.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=338; Record_ID=skin_sensitization_invitro_108; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=58.7; Reported_Response_Unit=%; Response=58.7; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Depletion Lys + Cys 71 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=353; Record_ID=skin_sensitization_invitro_112; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=71; Reported_Response_Unit=%; Response=71; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 4.38 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4238; Record_ID=skin_sensitization_invitro_982; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.38; Reported_Response_Unit=uM; Response=4.38; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 5.84 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4240; Record_ID=skin_sensitization_invitro_983; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.84; Reported_Response_Unit=uM; Response=5.84; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4242; Record_ID=skin_sensitization_invitro_984; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6; Reported_Response_Unit=uM; Response=6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 6.27 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4244; Record_ID=skin_sensitization_invitro_985; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.27; Reported_Response_Unit=uM; Response=6.27; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 6.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4246; Record_ID=skin_sensitization_invitro_986; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.5; Reported_Response_Unit=uM; Response=6.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 6.54 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4248; Record_ID=skin_sensitization_invitro_987; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.54; Reported_Response_Unit=uM; Response=6.54; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 7.19 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4250; Record_ID=skin_sensitization_invitro_988; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.19; Reported_Response_Unit=uM; Response=7.19; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 7.27 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4252; Record_ID=skin_sensitization_invitro_989; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.27; Reported_Response_Unit=uM; Response=7.27; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 7.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4254; Record_ID=skin_sensitization_invitro_990; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.5; Reported_Response_Unit=uM; Response=7.5; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 10.17 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4208; Record_ID=skin_sensitization_invitro_967; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=10.17; Reported_Response_Unit=uM; Response=10.17; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 13.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4210; Record_ID=skin_sensitization_invitro_968; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.1; Reported_Response_Unit=uM; Response=13.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 13.15 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4212; Record_ID=skin_sensitization_invitro_969; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.15; Reported_Response_Unit=uM; Response=13.15; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 13.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4214; Record_ID=skin_sensitization_invitro_970; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.5; Reported_Response_Unit=uM; Response=13.5; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 14 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4216; Record_ID=skin_sensitization_invitro_971; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14; Reported_Response_Unit=uM; Response=14; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 14.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4220; Record_ID=skin_sensitization_invitro_973; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.3; Reported_Response_Unit=uM; Response=14.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 14.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4222; Record_ID=skin_sensitization_invitro_974; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.5; Reported_Response_Unit=uM; Response=14.5; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 14.55 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4224; Record_ID=skin_sensitization_invitro_975; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.55; Reported_Response_Unit=uM; Response=14.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 14.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4226; Record_ID=skin_sensitization_invitro_976; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.8; Reported_Response_Unit=uM; Response=14.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 15.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4228; Record_ID=skin_sensitization_invitro_977; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.1; Reported_Response_Unit=uM; Response=15.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 15.57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4230; Record_ID=skin_sensitization_invitro_978; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.57; Reported_Response_Unit=uM; Response=15.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 15.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4232; Record_ID=skin_sensitization_invitro_979; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.9; Reported_Response_Unit=uM; Response=15.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 16.134 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4234; Record_ID=skin_sensitization_invitro_980; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.134; Reported_Response_Unit=uM; Response=16.134; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 18.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4236; Record_ID=skin_sensitization_invitro_981; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.2; Reported_Response_Unit=uM; Response=18.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC1.5 <44.21 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7600; Record_ID=skin_sensitization_invitro_1839; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=44.21; Reported_Response_Unit=uM; Response=44.21; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13046; Record_ID=skin_sensitization_invivo_3017; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 0.53 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13040; Record_ID=skin_sensitization_invivo_3011; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=0.53; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1989; 2598647; 10.1111/j.1600-0536.1989.tb03198.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 0.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13043; Record_ID=skin_sensitization_invivo_3014; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13062; Record_ID=skin_sensitization_invivo_3039; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13053; Record_ID=skin_sensitization_invivo_3026; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13048; Record_ID=skin_sensitization_invivo_3019; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13063; Record_ID=skin_sensitization_invivo_3042; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13051; Record_ID=skin_sensitization_invivo_3023; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 1.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13041; Record_ID=skin_sensitization_invivo_3012; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=1.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13038; Record_ID=skin_sensitization_invivo_3009; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Scholes 1992; 1544608; 10.1016/0278-6915(92)90138-b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 3.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13039; Record_ID=skin_sensitization_invivo_3010; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LLNA; Endpoint=EC3; Response=3.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization EC3 63.94 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4258; Record_ID=skin_sensitization_invitro_980; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=63.938000000000002; Reported_Response_Unit=uM; Response=63.94; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 103.52 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4260; Record_ID=skin_sensitization_invitro_975; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=103.52; Reported_Response_Unit=uM; Response=103.52; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 108 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4262; Record_ID=skin_sensitization_invitro_985; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=108; Reported_Response_Unit=uM; Response=108; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 109.24 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4264; Record_ID=skin_sensitization_invitro_987; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=109.24; Reported_Response_Unit=uM; Response=109.24; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 >110 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7670; Record_ID=skin_sensitization_invitro_1839; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=110; Reported_Response_Unit=uM; Response=110; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 111.52 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4266; Record_ID=skin_sensitization_invitro_989; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=111.52; Reported_Response_Unit=uM; Response=111.52; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 113.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4268; Record_ID=skin_sensitization_invitro_986; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=113.1; Reported_Response_Unit=uM; Response=113.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 120.19 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4270; Record_ID=skin_sensitization_invitro_969; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=120.19; Reported_Response_Unit=uM; Response=120.19; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 132.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4272; Record_ID=skin_sensitization_invitro_984; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=132.6; Reported_Response_Unit=uM; Response=132.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 135.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4274; Record_ID=skin_sensitization_invitro_968; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=135.4; Reported_Response_Unit=uM; Response=135.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 143.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4275; Record_ID=skin_sensitization_invitro_990; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=143.91999999999999; Reported_Response_Unit=uM; Response=143.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 148.25 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4277; Record_ID=skin_sensitization_invitro_982; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=148.25; Reported_Response_Unit=uM; Response=148.25; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 164.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4279; Record_ID=skin_sensitization_invitro_973; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=164.1; Reported_Response_Unit=uM; Response=164.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 168.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4281; Record_ID=skin_sensitization_invitro_979; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=168.1; Reported_Response_Unit=uM; Response=168.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 172.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4283; Record_ID=skin_sensitization_invitro_976; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=172.6; Reported_Response_Unit=uM; Response=172.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 194.14 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4285; Record_ID=skin_sensitization_invitro_972; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=194.14; Reported_Response_Unit=uM; Response=194.14; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 194.38 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4287; Record_ID=skin_sensitization_invitro_980; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=194.38; Reported_Response_Unit=uM; Response=194.38; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 219.66 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4290; Record_ID=skin_sensitization_invitro_978; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=219.66; Reported_Response_Unit=uM; Response=219.66; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 219.87 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4292; Record_ID=skin_sensitization_invitro_967; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=219.87; Reported_Response_Unit=uM; Response=219.87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 226.32 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4294; Record_ID=skin_sensitization_invitro_971; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=226.32; Reported_Response_Unit=uM; Response=226.32; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 348.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4296; Record_ID=skin_sensitization_invitro_991; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=348.9; Reported_Response_Unit=uM; Response=348.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 435.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4298; Record_ID=skin_sensitization_invitro_983; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=435.4; Reported_Response_Unit=uM; Response=435.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization IC50 443.48 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4300; Record_ID=skin_sensitization_invitro_988; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=443.48; Reported_Response_Unit=uM; Response=443.48; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 4.424 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4330; Record_ID=skin_sensitization_invitro_971; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=4.4240000000000004; Reported_Response_Unit=Unitless; Response=4.424; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 9.8 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4340; Record_ID=skin_sensitization_invitro_976; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.8000000000000007; Reported_Response_Unit=Unitless; Response=9.8; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 10.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4302; Record_ID=skin_sensitization_invitro_978; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=10.404999999999999; Reported_Response_Unit=Unitless; Response=10.4; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 11.94 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4303; Record_ID=skin_sensitization_invitro_977; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=11.938000000000001; Reported_Response_Unit=Unitless; Response=11.94; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 12.404 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4304; Record_ID=skin_sensitization_invitro_985; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=12.404; Reported_Response_Unit=Unitless; Response=12.404; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 14.68 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4306; Record_ID=skin_sensitization_invitro_975; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=14.675000000000001; Reported_Response_Unit=Unitless; Response=14.68; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 16.24 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4308; Record_ID=skin_sensitization_invitro_980; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.239999999999998; Reported_Response_Unit=Unitless; Response=16.24; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 16.488 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4305; Record_ID=skin_sensitization_invitro_972; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.488; Reported_Response_Unit=Unitless; Response=16.488; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 17.51 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4307; Record_ID=skin_sensitization_invitro_979; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.510000000000002; Reported_Response_Unit=Unitless; Response=17.51; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 17.866 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4309; Record_ID=skin_sensitization_invitro_981; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.866; Reported_Response_Unit=Unitless; Response=17.866; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 18.32 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4310; Record_ID=skin_sensitization_invitro_970; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.321000000000002; Reported_Response_Unit=Unitless; Response=18.32; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 18.45 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4311; Record_ID=skin_sensitization_invitro_974; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.446999999999999; Reported_Response_Unit=Unitless; Response=18.45; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 18.99 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4312; Record_ID=skin_sensitization_invitro_969; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.989999999999998; Reported_Response_Unit=Unitless; Response=18.99; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 22.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4314; Record_ID=skin_sensitization_invitro_986; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.2; Reported_Response_Unit=Unitless; Response=22.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 22.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4316; Record_ID=skin_sensitization_invitro_973; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.4; Reported_Response_Unit=Unitless; Response=22.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 23.25 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7573; Record_ID=skin_sensitization_invitro_1839; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=LuSens; Endpoint=Imax; Reported_Response=23.25398094; Reported_Response_Unit=Unitless; Response=23.25; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 23.31 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4318; Record_ID=skin_sensitization_invitro_982; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.306999999999999; Reported_Response_Unit=Unitless; Response=23.31; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 32.28 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4320; Record_ID=skin_sensitization_invitro_987; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=32.28; Reported_Response_Unit=Unitless; Response=32.28; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 32.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4322; Record_ID=skin_sensitization_invitro_984; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=32.4; Reported_Response_Unit=Unitless; Response=32.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 32.86 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4324; Record_ID=skin_sensitization_invitro_988; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=32.857999999999997; Reported_Response_Unit=Unitless; Response=32.86; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 33.16 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4326; Record_ID=skin_sensitization_invitro_968; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=33.161000000000001; Reported_Response_Unit=Unitless; Response=33.16; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 35.33 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4328; Record_ID=skin_sensitization_invitro_989; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=35.331000000000003; Reported_Response_Unit=Unitless; Response=35.33; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 41.47 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4332; Record_ID=skin_sensitization_invitro_990; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=41.47; Reported_Response_Unit=Unitless; Response=41.47; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 43.83 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4334; Record_ID=skin_sensitization_invitro_967; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=43.829000000000001; Reported_Response_Unit=Unitless; Response=43.83; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 44.7 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4336; Record_ID=skin_sensitization_invitro_991; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=44.7; Reported_Response_Unit=Unitless; Response=44.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Imax 57.45 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4338; Record_ID=skin_sensitization_invitro_983; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=57.454000000000001; Reported_Response_Unit=Unitless; Response=57.45; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2575; Record_ID=skin_sensitization_invivo_699; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.125; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 1.818 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2621; Record_ID=skin_sensitization_invivo_707; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=1.818; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 1.869 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2636; Record_ID=skin_sensitization_invivo_710; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=1.869; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 2.804 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2650; Record_ID=skin_sensitization_invivo_712; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.804; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 4 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2539; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2581; Record_ID=skin_sensitization_invivo_700; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 12 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2611; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=12; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 12.2 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2665; Record_ID=skin_sensitization_invivo_708; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=12.2; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 14.29 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2644; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=14.29; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 44 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2595; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=44; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Incidence of positive responses 50 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2627; Record_ID=skin_sensitization_invivo_709; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=50; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 76.92 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2573; Record_ID=skin_sensitization_invivo_699; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.125; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=76.92; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 310 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2591; Record_ID=skin_sensitization_invivo_702; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=310; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 337.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2537; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=337.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 590.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2582; Record_ID=skin_sensitization_invivo_701; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=590.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 620 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2619; Record_ID=skin_sensitization_invivo_707; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=620; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 697.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2616; Record_ID=skin_sensitization_invivo_706; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=697.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 775 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2625; Record_ID=skin_sensitization_invivo_709; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2594; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 1944 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2609; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1944; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area 3543 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2642; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3543; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 77.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2638; Record_ID=skin_sensitization_invivo_709; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=77.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 147.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2605; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=147.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 210.9375 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2590; Record_ID=skin_sensitization_invivo_700; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=210.9375; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 254.2 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2620; Record_ID=skin_sensitization_invivo_708; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=254.2; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 421.875 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2549; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=421.875; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 810 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2568; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=810; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 1106 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2659; Record_ID=skin_sensitization_invivo_712; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1106; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 1240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2655; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 1705 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2630; Record_ID=skin_sensitization_invivo_707; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1705; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 1866 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2645; Record_ID=skin_sensitization_invivo_710; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1866; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 117.8 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2601; Record_ID=skin_sensitization_invivo_703; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=117.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 124 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2671; Record_ID=skin_sensitization_invivo_708; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=124; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2019; 31356911; 10.1016/j.fct.2019.110710; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 155 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2633; Record_ID=skin_sensitization_invivo_709; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=155; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Danneman et al. 1983; 6686575; 10.1016/0278-6915(83)90203-X|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 168.75 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2586; Record_ID=skin_sensitization_invivo_700; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=168.75; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 206.7 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2656; Record_ID=skin_sensitization_invivo_712; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=206.7; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 348.8 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2641; Record_ID=skin_sensitization_invivo_710; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=348.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 648 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2564; Record_ID=skin_sensitization_invivo_697; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Induction dose per skin area, one positive response 885.8 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2651; Record_ID=skin_sensitization_invivo_711; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=885.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2618; Record_ID=skin_sensitization_invivo_706; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1976; 1032125; 10.1111/j.1600-0536.1976.tb03069.x|Marzulli and Maibach 1980; 7441083; Not available|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Cocchiara et al. 2005; 15811572; 10.1016/j.fct.2004.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2551; Record_ID=skin_sensitization_invivo_694; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024835; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|RIFM (undated); https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024835; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024835
ECHA 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =5 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5283; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/9/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15861395:F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_893408d1f33fe49af2d669f705254137
ECHA LOAEL =470 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f9a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837397_15850264:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc487893a577e96117af7cb74aea9f55
ECHA LOAEL <=570 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841099_15850266:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_370ba06ffde091915fc3820b84fee18a
ECHA LOAEL <=625 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841098_15850265:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9b7960169b8ac2059fe914422c3a4c0
ECHA LOAEL =1310 mg/kg bw/day Mouse oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f97a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830121_15850262:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c1d2f80b8e176d5e9d9966ad01ed51c
ECHA LOAEL =2500 mg/kg bw/day Mouse oral short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f9cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845794_15850270:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b7aa49570a5136de44625b3ac37b218
ECHA NOAEL =40 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f999; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15832059:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0939747d703bb222a53bc73508ec28f
ECHA NOAEL =125 mg/kg bw/day Rat oral chronic; 16 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6d4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19325/7/6/2?documentUUID=942931d5-5140-4af7-bd9c-98d99d43cc01; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850267_15850268:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e2a1d78ea06438468ce0d3efae8c443
ECHA NOAEL =200 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15850269:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ce9c05dcbed2deb7de8fa534faaaa8fd
ECHA NOAEL =235 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c96; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/8?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=stomach; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID:15820181:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_43b1827d6977d9d9afb7f33794535045
ECHA NOAEL >=275 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=body weight and weight gain|urinalysis|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841098_15850265:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a0cbc04e4953990544a3800ed027ae6d
ECHA NOAEL >=300 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=body weight and weight gain|urinalysis|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841099_15850266:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13eaca4ebc2b25e584bd720a58b3b3d4
ECHA NOAEL =656 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/8?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15820180:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_89a4ac9b09f65ae65a2f598417f5594c
ECHA NOAEL =1250 mg/kg bw/day Mouse oral short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f9cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845794_15850270:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e33f50aba6c05d619140857edc16c16a
ECHA NOAEL =4100 ppm Rat oral chronic; 105 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f6e4b0a7c65d21f9c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15843859:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a283cb96651eb6ae63390fa95dbbfedd
ToxValDB ECOTOX 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =15 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607775_15607776_15607777_15607778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5151c7e5e19359b432a63d7b99e41f9f
ToxValDB ECOTOX NOEL =1.88 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607775_15607776_15607777_15607778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d9be33dead1285a32358519fa2847123
ToxValDB ECOTOX NOEL =7.5 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607775_15607776_15607777_15607778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2fc035ac9329baefc977a37a11b72b30
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =2.204 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630733_15630734:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b93b1c6c4d5d1b8f7f736be9b1dc7195
ToxValDB GESTIS DNEL DNEL systemic =6.11 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630733_15630734:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac4745c5cfe0f21d0bd962e262cc36d2
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier SR60A3XG0F UNII - - - chemical -