Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

CINNAMAL

CAS Number
104-55-2
Function
Denaturant, Flavouring, Perfuming
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. III/76
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for CINNAMAL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 90 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 68 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1200 mg/kg bw/day oral mouse Reproductive COSMOS_DB
NOAEL 25 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1.5 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 570 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 650 mg/kg bw/day oral mouse Subchronic COSMOS_DB

Sensitization Profile

Contact sensitization data for CINNAMAL based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
2.5%
Cross-reactivity Group
fragrance-mix-I
Reaction Type
contact-dermatitis
IFRA Restricted — max 0.05% in finished products

Source: ESSCA/IVDK

Expert Verdict

CINNAMAL is listed in the EU CosIng database with functions: Denaturant, Flavouring, Perfuming It is restricted under EU Cosmetics Regulation. Restriction: III/76.

⚠️
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is CINNAMAL safe in cosmetics?

CINNAMAL is listed in the EU CosIng database with functions: Denaturant, Flavouring, Perfuming It is restricted under EU Cosmetics Regulation. Restriction: III/76. The EU classifies CINNAMAL as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is CINNAMAL allowed in the EU?

CINNAMAL EU regulatory status: Restricted. Maximum allowed concentration: III/76. This is based on EU Regulation 1223/2009 and its amendments.

What does CINNAMAL do in cosmetics?

CINNAMAL functions as: Denaturant, Flavouring, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 104-55-2.

What is the NOAEL for CINNAMAL?

The NOAEL (No Observed Adverse Effect Level) for CINNAMAL is 200 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check CINNAMAL compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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