Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

CINNAMAL

Also known as: 2-07-00-00273, Acrolein, 3-phenyl-, BRN 0605737, Caswell No. 221A, Cinnamylaldehyde (+11 more)

CINNAMAL (CAS 104-55-2) is a cosmetic cosmetic ingredient functioning as Denaturant, Flavouring, Perfuming. NOAEL 1.66667 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max III/76. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 104-55-2 →

Auto-generated CPSR Part A draft with source citations

CAS Number

104-55-2

View industrial chemical safety profile →

Function

Denaturant, Flavouring, Perfuming

Safety Rating

MODERATE

Chemistry & Identifiers

Formula

C9H8O

132.16 g/mol

EC Number

203-213-9

PubChem CID

637511

IUPAC Name

(E)-3-phenylprop-2-enal

InChIKey

KJPRLNWUNMBNBZ-QPJJXVBHSA-N

ChEBI: CHEBI:142921 Wikidata: Q60041699

Regulatory Status

EU EU Status restricted

EU Max Conc. III/76

US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for CINNAMAL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	5 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	25 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	68 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	73.5 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
NOAEL	90 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	200 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	270 mg/kg bw/day	oral	mouse	Carcinogenicity	COSMOS_DB
NOAEL	375 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	=40 mg/kg bw/day	oral	Rat	short-term	ToxValDB_ECHA_IUCLID
NOAEL	=125 mg/kg bw/day	oral	Rat	chronic	ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for CINNAMAL across SCCS product categories, with measured dermal absorption where available.

Sensitization Profile

Contact sensitization data for CINNAMAL based on clinical patch test studies and IFRA standards.

Sensitization Rate

moderate

Allergen Class

fragrance

EU Allergen Listed

yes

Patch Test Positive Rate

2.5%

Cross-reactivity Group

fragrance-mix-I

Reaction Type

contact-dermatitis

IFRA Restricted — max 0.05% in finished products

Source: ESSCA/IVDK

EPA ToxValDB — Toxicity Values

10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LD50	>1200 mg/kg	Rat	dermal	-	ECHA IUCLID
LD50	<5000 mg/kg	Rabbit	dermal	-	ECHA IUCLID
LD50	>1000 mg/kg	Rabbit	dermal	acute	ECHA IUCLID
LD50	>2000 mg/kg	Rat	dermal	short-term	ECHA IUCLID
LD50	=1260 mg/kg	Rabbit	dermal	acute	ECHA IUCLID
LD50	=3400 mg/kg	Guinea Pig	oral	-	ECHA IUCLID
LD50	=2220 mg/kg	Rat	oral	-	ECHA IUCLID
LD50	=3350 mg/kg	Rat	oral	-	ECHA IUCLID
LD50	=3400 mg/kg	Rat	oral	-	ECHA IUCLID
LD50	=2225 mg/kg	Mouse	oral	-	ECHA IUCLID

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

DPRA Cys %

76.66%

DPRA Lys %

57.4%

KeratinoSens IC50

148.25 µM

hCLAT CV75

31.1 µg/mL

LLNA EC3

1.1%

NESIL

77 µg/cm²

LLNA: Strong (1A) GHS: 1A Human: positive

Source: LLNA: Basketter and Scholes (1992) | Gerberick et al. (2005); DPRA: Gerberick et al. 2004 [DOI:10.1093/toxsci/kfh213] | Jaworska 2011 [DOI:10.1002/jat.2869]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Joint Research Centre of the European Union 2014; hCLAT: Sakaguchi et al. 2010 [DOI:10.1016/j.tiv.2010.05.012] | Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]; HPPT: [126] Kligman AM (1977): Report to RIFM, 17 June, unpublished.

HRIPT Human Patch Test Studies

5 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Dose µg/cm²	NESIL µg/cm²	Potency
HRIPT	94	591	591	non-sensitizer
HRIPT	-	591	591	moderate
HMT	-	337.5	-	-
HMT	-	337.5	-	-
HMT	-	1296	-	-

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Cosmetic-Specific Mechanism

Category: fragrance

Receptor targets: ERα (limited)

LOEC: 100 µM

EU status: restricted (allergen; max 0.1% leave-on)

weak modulator

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE; GROUP

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (III - Restricted)

BRIN Brazil/India Cosmetics

Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling

India: Restricted

Additional Jurisdictional Restrictions (1)

Jurisdiction	Status	Max %	Product Type
GCC	restricted	0.01	Rinse-off products

Expanded Dermal Absorption Data

Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.

Aggregated DA Values (1 records across 5 sources)

Type	DA %	Method	Skin Model	SCCS Ref
measured_in_vitro	<5	In vitro; metabolically viable full-thickness human skin; RP-HPLC	Full-thickness human breast/abdomen skin (6 female donors)	Smith et al. 2000 (Toxicol Appl Pharmacol) (2000)

Additional Ingredient Properties

6 property records from structured ingredient metadata.

allergen_detail

{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "fragrance-mix-I", "patch_test_frequency_pct": "2.5", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "ifra_max_level_pct": "0.05", "source": "ESSCA/IVDK"}

fragrance

{"cas_number": "104-55-2", "ingredient_class": "aroma_chemical", "chemical_class": "aldehyde", "odor_family": "spicy", "odor_description": "Warm, spicy cinnamon, slightly woody", "odor_strength": "very_strong", "odor_tenacity_hours": "24.0", "top_note": "yes", "heart_note": "yes", "base_note": "yes", "blending_factor_1_10": "9.0", "threshold_of_detection_ppb": "0.6", "molecular_weight_Da": "132.16…

pediatric_safety

{"safe_for_newborn_0_6m": "avoid", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "caution", "safe_for_child_3_12y": "caution", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "0.1", "adult_max_concentration_pct": "unlimited", "pediatric_dermal_absorption_factor": "higher", "immature_skin_barrier_risk": "moderate", "oral_ingestion_risk": "low", "eye_irritation_risk"…

pregnancy_detail

{"pregnancy_safe": "avoid", "breastfeeding_safe": "avoid", "trimester_restriction": "all", "risk_category": "not-rated", "reason": "Potent sensitizer; skin irritant; avoid in pregnancy", "alternative_ingredient": "Vanillin", "source": "dermatology literature"}

regulatory

{"eu_status": "restricted", "us_status": "allowed", "eu_max_concentration": "0.001", "restricted_in": "rinse-off: >0.01%, leave-on: >0.001%", "regulation_reference": "Annex III/205"}

skin_suitability

{"oily_skin": "avoid", "dry_skin": "avoid", "sensitive_skin": "avoid", "combination_skin": "avoid", "normal_skin": "avoid", "acne_prone": "avoid", "rosacea": "avoid", "eczema": "avoid", "hyperpigmentation": "avoid", "aging_mature": "avoid", "dehydrated": "avoid", "skin_benefit_primary": "fragrance", "skin_benefit_secondary": "flavoring", "mechanism_of_action": "Cinnamon aldehyde, highly allergenic…

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (3)

Carcinogen Classification

trans-Cinnamaldehyde | TR-514: Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (2004 ) | 09/05/02 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of this 2-year feed study, there was no evidence of carcinogenic activity of transcinnamaldehyde in male or female

Source: NTP Technical Reports

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

Skin Eye Respiratory Irritation

Primary eye irritant ... Dermal irritant. | No primary dermal irritation was observed in human subjects exposed for 48 hours to a solution of a 3% active ingredient, while severe primary dermal irritation was observed in human subjects after exposure to 8% active ingredient.

Source: Hazardous Substances Data Bank (HSDB)

Regulatory (2)

JECFA Number

656

Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

JECFA Evaluation

ZIMTALDEHYDE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79

Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Deodorizer Flavouring and nutrient Fragrance

Regulatory List Membership (6)

EU Regulated in Personal Care EU Restricted for Children (Cosmetics) IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS) Consumer Product Chemical EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for CINNAMAL.

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to CINNAMAL by CAS number or substance name.

Studies

Lowest NOAEL

5 mg/kg bw/day

Highest NOAEL

1250 mg/kg bw/day

COSMOS_DB ToxValDB_ECHA_IUCLID

Dermal Absorption

View details ->

Absorption %	Method	Vehicle
<5	In vitro; metabolically viable full-thickness human skin; RP-HPLC	Neat

Known Synonyms

2-07-00-00273 Acrolein, 3-phenyl- BRN 0605737 Caswell No. 221A Cinnamylaldehyde Cinnemaldehyde EINECS 203-213-9 EPA Pesticide Chemical Code 040506 FEMA No. 2286 FEMA Number 2286 NCI-C56111 beta-Phenylcrolein Hefty Dog and Cat Repellent 3-Fenylpropenal Aldehyd skoricovy UNII-SR60A3XG0F

Chemical Function

Fragrance

Regulatory Lists

Cons electronics mech appliances and machinery; Europe Europe active_ingredient; Europe; Pesticides Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener Europe; Personal care - body hygiene - hand soap children; Europe; Personal care children; Europe; Personal care - dental care - toothpaste children; Europe; Personal care children; Europe; Personal care children; detected; Europe; Personal care - body hygiene - body wash detected; Europe; Personal care - make-up and related detected; Europe; Personal care - make-up and related Cleaning products and household care - laundry and fabric treatment - fabric softener; detected; Europe consumer_product; detected; Europe detected; Europe; Personal care - sexual wellness detected; Europe; Personal care - sexual wellness detected; Europe; Personal care - sexual wellness Europe; Personal care - sexual wellness

Australian Status

AICIS status: listed

Frequently Asked Questions

Is CINNAMAL safe in cosmetics?

CINNAMAL has a safety rating of "MODERATE" in our database. EU status: restricted. 10 toxicological study endpoint(s) are available in our database.

Is CINNAMAL allowed in the EU?

CINNAMAL EU regulatory status: restricted. Maximum allowed concentration: III/76. This is based on EU Regulation 1223/2009 and its amendments.

What does CINNAMAL do in cosmetics?

CINNAMAL functions as: Denaturant, Flavouring, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 104-55-2.

What is the NOAEL for CINNAMAL?

The NOAEL (No Observed Adverse Effect Level) for CINNAMAL is 5 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is CINNAMAL used outside cosmetics?

CINNAMAL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

Check CINNAMAL compliance across multiple jurisdictions:

Ingredient Decoder

Paste a full ingredient list for instant analysis

82 Allergen Checker

Check for EU declarable fragrance allergens

Substance Compliance

Check compliance across multiple jurisdictions

MoS Calculator

Calculate Margin of Safety using SCCS methodology

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)

Excellent Same category

Fragrance (perfuming), masking

2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)

Excellent Same category

Fragrance (rich woody, orris/iris roo...

3,6-Dimethyl-3-Octyl Acetate

Excellent Same category

Fragrance / Perfuming agent with flor...

3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)

Excellent Same category

Perfuming / Fragrance (sandalwood note)

4-Tert-Butylcyclohexyl Acetate

Excellent Same category

Fragrance

Acetoin

Excellent Same category

Skin conditioning, fragrance

(20S)-Protopanaxadiol

Moderate Similar safety

(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract

Moderate Similar safety

Skin conditioning

(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract

Moderate Similar safety

Antimicrobial, antioxidant, humectant

(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract

Moderate Similar safety

Skin conditioning

(Lepidium Meyenii/Sarcodon Aspratus) Root Water

Moderate Similar safety

Skin conditioning

(Licorice/Reynoutria Japonica) Root/Stem Extract

Moderate Similar safety

Skin conditioning, antioxidant

2-Ethylhexanol

Good Chemical family

Solvent, Fragrance ingredient

4-Methylbenzaldehyde

Moderate Chemical family

Fragrance (perfuming); also known as ...

Anisyl Acetate

Good Chemical family

Perfuming

Browse all 30,000+ ingredients A-Z →

Is CINNAMAL in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CINNAMAL in your formulation.

Ingredient Decoder MoS Calculator