NOAEL Studies Cosmetic Ingredient

cis-3-Hexenyl Salicylate NOAEL Studies

INCI: CIS-3-HEXENYL SALICYLATE

CAS: 65405-77-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9030; row=14298; data_type=In Vivo; mixture=Chemical; chemical_name=(3Z)-Hex-3-en-1-yl salicylate; preferred_name=(3Z)-Hexenyl salicylate; dtxsid=DTXSID8037750; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8037750; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9253; Record_ID=skin_sensitization_invivo_2048; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8037750; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8037750
NTP_ICE_skin_sensitization Induction dose per skin area 2025 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9251; Record_ID=skin_sensitization_invivo_2048; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8037750; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2025; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8037750
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9257; Record_ID=skin_sensitization_invivo_2048; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8037750; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8037750
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca0a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12174/7/6/2?documentUUID=5014baaf-ec49-4486-bdf3-376981d65936; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842808_15842809:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d14fade6121d02d8a44333a203564b8
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca0a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12174/7/6/2?documentUUID=5014baaf-ec49-4486-bdf3-376981d65936; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842808_15842809:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6a0958471b7da6a2e9340544507db6e7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.59 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632550:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_566a342c8871be5b651c867adf9846c0
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL =120 mg/kg bw/day Rat oral subchronic; 42 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dcde4b0a676289dd58c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Water Consumption: increase|Urinalysis: Volume increase, Osmo decrease|Hematology: RBC decrease, MCV increase, MCHC increase, RET increase, Eosin decrease, Mono increase|Blood Chemistry: Alb increase, A/G increase, AST increase, T-Bil increase, PL increase, CRE increase, IP increase|Necropsy: Stomach-Dark Red Focus, glandular stomach|Histopathology: Stomach-Erosion, glandular stomach Bone-Increased trabecular bone, femoral; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|urinalysis; STUDY_GROUP=HESS:15638105:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c7249a1683c381adff0e4da862dbad9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier C78Y9OR6YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H16O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C78Y9OR6YH"}
openFDA substances FDA UNII substance identifier C78Y9OR6YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H16O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C78Y9OR6YH"}
openFDA substances FDA UNII substance identifier C78Y9OR6YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H16O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C78Y9OR6YH"}
openFDA substances FDA UNII substance identifier C78Y9OR6YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H16O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C78Y9OR6YH"}