NOAEL Studies
Cosmetic Ingredient
cis-3-Hexenyloxyacetaldehyde NOAEL Studies
INCI: CIS-3-HEXENYLOXYACETALDEHYDE
CAS: 68901-15-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ToxValDB_ECHA_IUCLID 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =16.1 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/9/3?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15825110:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4aef15bf5b84e2bb76e6115f962a4e67 |
| ToxValDB_ECHA_IUCLID | NOAEL | =32.2 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae6d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15849763:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4259a434b193335cf1fc4a6cd96333cd |
| ToxValDB_ECHA_IUCLID | NOAEL | =32.8 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae6d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15849762:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d8ed366c1a2751a7672dc3ac40e88f09 |
| ToxValDB_ECHA_IUCLID | NOAEL | =60 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/9/3?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15825111:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35c1dded5622d2271b2c6f1bed6caf52 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=67.6 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831483_15849760:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ffb062467b39a5f3e833e847a9d1db65 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=75.7 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831482_15849761:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_670f185d9c69942c5f3848976e2ba788 |
| ToxValDB_ECHA_IUCLID | NOEL | =20.1 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831483_15849760:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6d4f7406d3c6ed59f7c02a9e2ffc290 |
| ToxValDB_ECHA_IUCLID | NOEL | =23.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/6/2?documentUUID=3de239e8-5c5d-4c56-98bd-f8ecfc5b8ff6; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831482_15849761:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96f19554a7ed1758067c8406e8edbb2e |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3.34 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629585:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_adbe92728f7c59e8b9efa01423e18e20 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | B2R58HW644 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H18O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B2R58HW644"} |
| openFDA substances | FDA UNII substance identifier | B2R58HW644 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H18O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B2R58HW644"} |
| openFDA substances | FDA UNII substance identifier | B2R58HW644 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H18O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B2R58HW644"} |
| openFDA substances | FDA UNII substance identifier | B2R58HW644 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H18O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B2R58HW644"} |