Is cis-3-Hexenyloxyacetaldehyde safe in cosmetics?
cis-3-Hexenyloxyacetaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
cis-3-Hexenyloxyacetaldehyde
Also known as: Acetic acid, (cyclohexyloxy)-, 2-propenyl ester, Acetic acid, 2-(cyclohexyloxy)-, 2-propen-1-yl ester, Allyl (cyclohexyloxy)acetate, Allyl cyclohexyloxyacetate, EINECS 272-657-3 (+2 more)
INCI: CIS-3-HEXENYLOXYACETALDEHYDE
cis-3-Hexenyloxyacetaldehyde (CAS 68901-15-5) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with green, fresh, floral character; α,β-unsaturated. Reported NOAEL =16.1 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 68901-15-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with green, fresh, floral character; α,β-unsaturated aldehyde with ether linkage
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
prop-2-enyl 2-cyclohexyloxyacetate
InChIKey
MBUYSYKXSMTIPP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR monograph available; RIFM-assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyloxyacetaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for cis-3-Hexenyloxyacetaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =16.1 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =32.2 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =32.8 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =60 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyloxyacetaldehyde.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to cis-3-Hexenyloxyacetaldehyde by CAS number or substance name.
Studies
4
Lowest NOAEL
16.1 mg/kg bw/day
Highest NOAEL
60 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetic acid, (cyclohexyloxy)-, 2-propenyl ester
Acetic acid, 2-(cyclohexyloxy)-, 2-propen-1-yl ester
Allyl (cyclohexyloxy)acetate
Allyl cyclohexyloxyacetate
EINECS 272-657-3
Cyclogalbanate
Galbanum oxyacetate
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is cis-3-Hexenyloxyacetaldehyde allowed in the EU?
cis-3-Hexenyloxyacetaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyloxyacetaldehyde do in cosmetics?
cis-3-Hexenyloxyacetaldehyde functions as: Fragrance ingredient with green, fresh, floral character; α,β-unsaturated aldehyde with ether linkage. It is classified as a cosmetic ingredient in our database. CAS number: 68901-15-5.
What is the NOAEL for cis-3-Hexenyloxyacetaldehyde?
The NOAEL (No Observed Adverse Effect Level) for cis-3-Hexenyloxyacetaldehyde is =16.1 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is cis-3-Hexenyloxyacetaldehyde used outside cosmetics?
cis-3-Hexenyloxyacetaldehyde also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyloxyacetaldehyde compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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