cis-3-Methyl-5-phenyl-2-pentenenitrile

INCI: CIS-3-METHYL-5-PHENYL-2-PENTENENITRILE

CAS Number
67052-45-3 (most likely; also reported as Tropenitrile / Citralva-related nitrile)
Function
Fragrance ingredient (citrus, green, herbal; nitrile musk/green family)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No CIR monograph; RIFM-assessed within nitrile fragrance class

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

α,β-unsaturated nitrile with structural alert as potential electrophile and Michael acceptor; IFRA limits are critical; nitrile class requires repeat dose and reproductive toxicity data.

⚠️
Concern Level: High

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is cis-3-Methyl-5-phenyl-2-pentenenitrile safe in cosmetics?

α,β-unsaturated nitrile with structural alert as potential electrophile and Michael acceptor; IFRA limits are critical; nitrile class requires repeat dose and reproductive toxicity data. The EU classifies cis-3-Methyl-5-phenyl-2-pentenenitrile as "permitted". Safety rating: MODERATE.

Is cis-3-Methyl-5-phenyl-2-pentenenitrile allowed in the EU?

cis-3-Methyl-5-phenyl-2-pentenenitrile EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does cis-3-Methyl-5-phenyl-2-pentenenitrile do in cosmetics?

cis-3-Methyl-5-phenyl-2-pentenenitrile functions as: Fragrance ingredient (citrus, green, herbal; nitrile musk/green family). It is classified as a cosmetic ingredient in our database. CAS number: 67052-45-3 (most likely; also reported as Tropenitrile / Citralva-related nitrile).

What is the Margin of Safety for cis-3-Methyl-5-phenyl-2-pentenenitrile?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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