Regulatory Status
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Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Menthoxypropanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 738 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| LOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Low irritation profile; synthetic origin means no batch variability from botanical allergens; minimal sensitization risk at typical use levels. Synthetic menthol derivative (3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol); provides a smooth, long-lasting cooling/refreshing sensation without the sharp bite of menthol; 1,3-propanediol backbone enhances water solubility and skin feel; non-volatile and odorless, making it ideal where cooling is wanted without minty scent; trade nam...
Regulatory Flags
Frequently Asked Questions
Is Menthoxypropanediol safe in cosmetics?
Low irritation profile; synthetic origin means no batch variability from botanical allergens; minimal sensitization risk at typical use levels. Synthetic menthol derivative (3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol); provides a smooth, long-lasting cooling/refreshing sensation without the sharp bite of menthol; 1,3-propanediol backbone enhances water solubility and skin feel; non-volatile and odorless, making it ideal where cooling is wanted without minty scent; trade nam... The EU classifies Menthoxypropanediol as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Menthoxypropanediol allowed in the EU?
Menthoxypropanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthoxypropanediol do in cosmetics?
Menthoxypropanediol functions as: Refreshing, Masking, Fragrance Functional (excipient of perfume oils/flavors). It is classified as a cosmetic ingredient in our database. CAS number: 87061-04-9.
What is the Margin of Safety for Menthoxypropanediol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Menthoxypropanediol?
The NOAEL (No Observed Adverse Effect Level) for Menthoxypropanediol is 738 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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