cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene

INCI: NOT ASSIGNED

CAS Number
63449-64-9
Function
Fragrance with green, leafy odor profile
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR review; RIFM safety assessment completed; permitted in fragrances

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Genotoxicity, repeated dose, reproductive, and sensitization endpoints rely on read-across from acetaldehyde ethyl cis-3-hexenyl acetal (CAS 28069-74-1).

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene safe in cosmetics?

Genotoxicity, repeated dose, reproductive, and sensitization endpoints rely on read-across from acetaldehyde ethyl cis-3-hexenyl acetal (CAS 28069-74-1). The EU classifies cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene as "permitted". Safety rating: GOOD.

Is cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene allowed in the EU?

cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene do in cosmetics?

cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene functions as: Fragrance with green, leafy odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 63449-64-9.

What is the Margin of Safety for cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for cis,cis-1,1'-(Ethylidenebis-oxy)dihex-3-ene in your formulation.