NOAEL Studies
Fragrance
Citral NOAEL Studies
INCI: CITRAL
CAS: 5392-40-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 500 | ppm | mouse | oral | 105 week | Chronic | REACH;PAFA; Toxicol. Sci., 71, 198-206; 2003 |
| COSMOS_DB | LOAEL | 1000 | ppm | rat | oral | 105 week | Chronic | REACH;PAFA; Toxicol. Sci., 71, 198-206; 2003 |
| COSMOS_DB | NOAEL | 120 | mg/kg bw/day | mouse | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 125 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 210 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 534 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 745 | mg/kg bw/day | mouse | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 820 | mg/kg bw/day | rat | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1140 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1500 | mg/kg bw/day | rat | oral | 5 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2280 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2400 | mg/kg bw/day | rat | oral | 10 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 8550 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 63 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 345 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=f1622fee-a327-47d2-986f-6fdf20323add |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 335 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2bc30d85-9745-4afa-bcd9-6ffeb11c531b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 210 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d66f3eb6-ffef-43b7-bd1a-4b71a0f99a81 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 60 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=c93f2316-b49d-4bbd-9d2e-190fed7ada41 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 745 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ac0809e6-35ac-4ff7-b40b-91776e408045 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 790 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d5dee5e-d4b3-439f-af3b-dc19b9b658f8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 120 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=06c9da77-bd84-4c95-9000-7123e1798b84_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=06c9da77-bd84-4c95-9000-7123e1798b84/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=61622051-d75d-4432-b088-18576997e955 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1140 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=03da6358-9305-413f-bbe2-87a6bae07787 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 8850 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=06ca5b3f-5339-461c-80e1-22b48bb4d9b4 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1068 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=5670a079-f1a7-4a59-b83d-1d1991b931ac |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 345 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=f1622fee-a327-47d2-986f-6fdf20323add |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 335 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2bc30d85-9745-4afa-bcd9-6ffeb11c531b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 210 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d66f3eb6-ffef-43b7-bd1a-4b71a0f99a81 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 60 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=c93f2316-b49d-4bbd-9d2e-190fed7ada41 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 745 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ac0809e6-35ac-4ff7-b40b-91776e408045 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 790 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d5dee5e-d4b3-439f-af3b-dc19b9b658f8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 120 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=06c9da77-bd84-4c95-9000-7123e1798b84_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=06c9da77-bd84-4c95-9000-7123e1798b84/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=61622051-d75d-4432-b088-18576997e955 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1140 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=03da6358-9305-413f-bbe2-87a6bae07787 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 8850 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=06ca5b3f-5339-461c-80e1-22b48bb4d9b4 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1068 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=5670a079-f1a7-4a59-b83d-1d1991b931ac |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 345 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=f1622fee-a327-47d2-986f-6fdf20323add |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 335 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2bc30d85-9745-4afa-bcd9-6ffeb11c531b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 210 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d66f3eb6-ffef-43b7-bd1a-4b71a0f99a81 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 60 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=c93f2316-b49d-4bbd-9d2e-190fed7ada41 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 745 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ac0809e6-35ac-4ff7-b40b-91776e408045 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 790 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d5dee5e-d4b3-439f-af3b-dc19b9b658f8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 120 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=06c9da77-bd84-4c95-9000-7123e1798b84_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=06c9da77-bd84-4c95-9000-7123e1798b84/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=61622051-d75d-4432-b088-18576997e955 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1140 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=03da6358-9305-413f-bbe2-87a6bae07787 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 8850 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=06ca5b3f-5339-461c-80e1-22b48bb4d9b4 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1068 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=5670a079-f1a7-4a59-b83d-1d1991b931ac |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=7edb035c-dacb-4e4b-90cb-91899f7e8e74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=other:; key_result=false; entry_uuid=43dcf060-5148-4495-b2ab-ab08800667b1 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=6d334f34-392c-4821-bc9c-1b1e257a26ba |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 60 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=bc45b05a-be0e-4727-b215-32651d4aab1c_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=bc45b05a-be0e-4727-b215-32651d4aab1c/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=c8679084-da2f-40a6-9c6f-e8842d08af4d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=ab99bdc4-dfef-439a-9fc2-aacefea4e1ce |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 570 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=304c9167-bf81-4172-9064-306e5a92b451 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1140 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=b843c4d2-c0e5-4fa5-8001-a53fe28249be |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 4275 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=94b89980-06a1-45a7-b765-282b9dab75bd |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 534 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=149fb423-1213-4453-9cf9-8a601b1a7a74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=7edb035c-dacb-4e4b-90cb-91899f7e8e74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=other:; key_result=false; entry_uuid=43dcf060-5148-4495-b2ab-ab08800667b1 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=6d334f34-392c-4821-bc9c-1b1e257a26ba |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 60 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=bc45b05a-be0e-4727-b215-32651d4aab1c_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=bc45b05a-be0e-4727-b215-32651d4aab1c/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=c8679084-da2f-40a6-9c6f-e8842d08af4d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=ab99bdc4-dfef-439a-9fc2-aacefea4e1ce |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 570 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=304c9167-bf81-4172-9064-306e5a92b451 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1140 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=b843c4d2-c0e5-4fa5-8001-a53fe28249be |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 4275 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=94b89980-06a1-45a7-b765-282b9dab75bd |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 534 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=149fb423-1213-4453-9cf9-8a601b1a7a74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=7edb035c-dacb-4e4b-90cb-91899f7e8e74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=other:; key_result=false; entry_uuid=43dcf060-5148-4495-b2ab-ab08800667b1 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=6d334f34-392c-4821-bc9c-1b1e257a26ba |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 60 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=bc45b05a-be0e-4727-b215-32651d4aab1c_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=bc45b05a-be0e-4727-b215-32651d4aab1c/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=c8679084-da2f-40a6-9c6f-e8842d08af4d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=ab99bdc4-dfef-439a-9fc2-aacefea4e1ce |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 570 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=304c9167-bf81-4172-9064-306e5a92b451 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1140 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=b843c4d2-c0e5-4fa5-8001-a53fe28249be |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 4275 | mg/kg bw/day | mouse | oral: feed | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=94b89980-06a1-45a7-b765-282b9dab75bd |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 534 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=149fb423-1213-4453-9cf9-8a601b1a7a74 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 2280 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=6cc07cdb-5de9-4678-93e7-af791cbe497b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 2280 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=6cc07cdb-5de9-4678-93e7-af791cbe497b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 2280 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=6cc07cdb-5de9-4678-93e7-af791cbe497b |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =6 | mg/kg bw | Unspecified | - | - | other | EFSA CEF - 2010 - OutputID 2050 - Scientific Opinion on Flavouring Group Evaluation 72 (FGE.72): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids. Esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010). - doi:10.2903/j.efsa.2010.1402 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =60 | mg/kg bw | Unspecified | - | - | other | EFSA CEF - 2013 - OutputID 2375 - Scientific Opinion on Flavouring Group Evaluation 72, Revision 1 (FGE.72Rev1): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids, esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2013.3392 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =345 | mg/kg bw/day | Rat | oral: feed | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =6 | mg/kg bw | Unspecified | - | - | other | EFSA CEF - 2010 - OutputID 2050 - Scientific Opinion on Flavouring Group Evaluation 72 (FGE.72): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids. Esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010). - doi:10.2903/j.efsa.2010.1402 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =60 | mg/kg bw | Unspecified | - | - | other | EFSA CEF - 2013 - OutputID 2375 - Scientific Opinion on Flavouring Group Evaluation 72, Revision 1 (FGE.72Rev1): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids, esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2013.3392 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =345 | mg/kg bw/day | Rat | oral: feed | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =0.5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FEEDAP - 2011 - OutputID 248 - Consumers - Scientific Opinion on the safety and efficacy of FRESTA F for weaned piglets - doi:10.2903/j.efsa.2011.2139 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =0.5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FEEDAP - 2011 - OutputID 248 - Consumers - Scientific Opinion on the safety and efficacy of FRESTA F for weaned piglets - doi:10.2903/j.efsa.2011.2139 |
INCHEM_WHO_jecfa_jecmono_v52je15 40 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v52je15 | ADI | ~0.15 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=357b7ff77ce81248; raw_unit=mg/kg bw; context=It was also noted that even the total combined daily intake of all 32 flavouring agents under evaluation (approximately 0.15 mg/kg bw in Europe and the USA) is less than the group ADI. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | ADI | ~0.15 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=357b7ff77ce81248; raw_unit=mg/kg bw; context=It was also noted that even the total combined daily intake of all 32 flavouring agents under evaluation (approximately 0.15 mg/kg bw in Europe and the USA) is less than the group ADI. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | ADI | =0.5 | mg/kg bw/day | - | - | short-term | Health guidance value | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b712630060595c84; raw_unit=mg/kg bw; context=A group ADI of 00.5 mg/kg bw, expressed as citral, was established for citral, geranyl acetate, citronellol, linalool, and linalyl acetate on the basis of their clearly-defined metabolism, rapid excretion, and low toxicity in short-term studies. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | ADI | =0.5 | mg/kg bw/day | - | - | short-term | Health guidance value | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b712630060595c84; raw_unit=mg/kg bw; context=A group ADI of 00.5 mg/kg bw, expressed as citral, was established for citral, geranyl acetate, citronellol, linalool, and linalyl acetate on the basis of their clearly-defined metabolism, rapid excretion, and low toxicity in short-term studies. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =1.36 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=986eb772a3803866; raw_unit=mg/kg bw per day; context=The NOEL for 2,4-dimethyl-2-pentenoic acid was 1.36 mg/kg bw per day in male rats and 1.55 mg/kg bw per day in female rats, the highest dose tested (Posternak, 1968). (iii) dl-Citronellol (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =1.36 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=986eb772a3803866; raw_unit=mg/kg bw per day; context=The NOEL for 2,4-dimethyl-2-pentenoic acid was 1.36 mg/kg bw per day in male rats and 1.55 mg/kg bw per day in female rats, the highest dose tested (Posternak, 1968). (iii) dl-Citronellol (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =50 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=df1d5b3a050ce928; raw_unit=mg/kg bw per day; context=The NOEL for citral was 50 mg/kg bw per day for maternal toxicity and 160 mg/kg bw per day for developmental toxicity (Hoberman et al., 1989). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =50 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=df1d5b3a050ce928; raw_unit=mg/kg bw per day; context=The NOEL for citral was 50 mg/kg bw per day for maternal toxicity and 160 mg/kg bw per day for developmental toxicity (Hoberman et al., 1989). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =51 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=81bd93ff31018159; raw_unit=mg/kg bw per day; context=The NOEL for citronellol was 51 mg/kg bw per day in male rats and 56 mg/kg bw per day in female rats, the highest dose tested (Oser, 1958b). (iv) Geraniol (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =51 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=81bd93ff31018159; raw_unit=mg/kg bw per day; context=The NOEL for citronellol was 51 mg/kg bw per day in male rats and 56 mg/kg bw per day in female rats, the highest dose tested (Oser, 1958b). (iv) Geraniol (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =52 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2a560ce688631c4e; raw_unit=mg/kg bw per day; context=The NOEL for citral was 52 mg/kg bw per day for male rats and 60 mg/kg bw per day for female rats, the highest dose tested (Oser, 1958a). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =52 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2a560ce688631c4e; raw_unit=mg/kg bw per day; context=The NOEL for citral was 52 mg/kg bw per day for male rats and 60 mg/kg bw per day for female rats, the highest dose tested (Oser, 1958a). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =60 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=9521f717efae07ee; raw_unit=mg/kg bw per day; context=The NOEL of 60 mg/kg bw per day (National Toxicology Program, 2003) for citral is >500 times more than the estimated daily intakes of 114 mg/kg bw in Europe and 117 mg/kg bw in the USA when used a flavouring agent See note 4 * 8-Ocimenyl acetate 1226 197098-61-6 No Europe: |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =60 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=9521f717efae07ee; raw_unit=mg/kg bw per day; context=The NOEL of 60 mg/kg bw per day (National Toxicology Program, 2003) for citral is >500 times more than the estimated daily intakes of 114 mg/kg bw in Europe and 117 mg/kg bw in the USA when used a flavouring agent See note 4 * 8-Ocimenyl acetate 1226 197098-61-6 No Europe: |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =100 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=e8479535bdfe79db; raw_unit=mg/kg bw per day; context=The NOEL for citral was 100 mg/kg bw per day on the basis of decreased body weights (in particular in females) (National Toxicology Program, 2003). (d) Genotoxicity Testing for genotoxicity has been carried out with six of the 32 flavouring agents in this group (Nos 1209, 1219, 1220, 1223, 1225, and 123 |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =100 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=e8479535bdfe79db; raw_unit=mg/kg bw per day; context=The NOEL for citral was 100 mg/kg bw per day on the basis of decreased body weights (in particular in females) (National Toxicology Program, 2003). (d) Genotoxicity Testing for genotoxicity has been carried out with six of the 32 flavouring agents in this group (Nos 1209, 1219, 1220, 1223, 1225, and 123 |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =125 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=ea19e09729190fcd; raw_unit=mg/kg bw per day; context=On this basis, the NOEL for citral was 125 mg/kg bw per day for maternal toxicity and 250 mg/kg bw per day for developmental toxicity (Vollmuth et al., 1990). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =125 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=ea19e09729190fcd; raw_unit=mg/kg bw per day; context=On this basis, the NOEL for citral was 125 mg/kg bw per day for maternal toxicity and 250 mg/kg bw per day for developmental toxicity (Vollmuth et al., 1990). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =142.857142857143 | mg/kg bw/day | Rat | oral | 5 days | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b2736008122eadb9; raw_unit=mg/kg bw per day; unit_normalization=converted from weekly dose; context=In groups of 50 male and 50 female Fischer 344/N rats given this mixture at a dose of 0, 1000 or 2000 mg/kg bw per day, 5 days per week for 103 weeks by gavage, the NOEL for the mixture was 1000 mg/kg bw per day, corresponding to an estimated dose of 710 mg/kg bw per day of geranyl acetate and 290 mg/kg bw per day of citronellyl acetate. (i) Citral (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =142.857142857143 | mg/kg bw/day | Rat | oral | 5 days | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b2736008122eadb9; raw_unit=mg/kg bw per day; unit_normalization=converted from weekly dose; context=In groups of 50 male and 50 female Fischer 344/N rats given this mixture at a dose of 0, 1000 or 2000 mg/kg bw per day, 5 days per week for 103 weeks by gavage, the NOEL for the mixture was 1000 mg/kg bw per day, corresponding to an estimated dose of 710 mg/kg bw per day of geranyl acetate and 290 mg/kg bw per day of citronellyl acetate. (i) Citral (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <345 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6e68b40be4c28ee2; raw_unit=mg/kg bw per day; context=The NOEL for citral was <345 mg/kg bw per day in male rats, on the basis of nephropathy. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <345 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6e68b40be4c28ee2; raw_unit=mg/kg bw per day; context=The NOEL for citral was <345 mg/kg bw per day in male rats, on the basis of nephropathy. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =500 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=39378074f773814b; raw_unit=mg/kg bw per day; context=The NOEL for citral was 500 mg/kg bw per day, the highest dose tested (Hagan et al., 1967). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =500 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=39378074f773814b; raw_unit=mg/kg bw per day; context=The NOEL for citral was 500 mg/kg bw per day, the highest dose tested (Hagan et al., 1967). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <534 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=461043bc731e7211; raw_unit=mg/kg bw per day; context=The NOEL was <534 mg/kg bw per day on the basis of increased liver weights. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <534 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=461043bc731e7211; raw_unit=mg/kg bw per day; context=The NOEL was <534 mg/kg bw per day on the basis of increased liver weights. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =570 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=f413a3a2971ee2a0; raw_unit=mg/kg bw per day; context=The NOEL for citral was 570 mg/kg bw per day on the basis of nasal lesions and decreased body weights (Dieter et al., 1993). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =570 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=f413a3a2971ee2a0; raw_unit=mg/kg bw per day; context=The NOEL for citral was 570 mg/kg bw per day on the basis of nasal lesions and decreased body weights (Dieter et al., 1993). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =675 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=71fb18eb47f5afe9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL was 675 mg/kg bw per day, on the basis of decreased body weights and body-weight gains, and bone marrow atrophy (National Toxicology Program, 2003). (ii) 2,4-Dimethyl-2-pentenoic acid (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =675 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=71fb18eb47f5afe9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL was 675 mg/kg bw per day, on the basis of decreased body weights and body-weight gains, and bone marrow atrophy (National Toxicology Program, 2003). (ii) 2,4-Dimethyl-2-pentenoic acid (No. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <745 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=53988f6f6e951628; raw_unit=mg/kg bw per day; context=The NOEL for citral was <745 mg/kg bw per day in male mice on the basis of decreased body weights and body-weight gains, and reductions in lymphocyte and leukocyte counts. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <745 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=53988f6f6e951628; raw_unit=mg/kg bw per day; context=The NOEL for citral was <745 mg/kg bw per day in male mice on the basis of decreased body weights and body-weight gains, and reductions in lymphocyte and leukocyte counts. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <790 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6c3849630141e03c; raw_unit=mg/kg bw per day; context=In female mice, the NOEL was <790 mg/kg bw per day on the basis of decreased body weights and body-weight gains (National Toxicology Program, 2003). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | <790 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6c3849630141e03c; raw_unit=mg/kg bw per day; context=In female mice, the NOEL was <790 mg/kg bw per day on the basis of decreased body weights and body-weight gains (National Toxicology Program, 2003). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =1140 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a683b140a1d0a6ac; raw_unit=mg/kg bw per day; context=The NOEL for citral was 1140 mg/kg bw per day in male rats on the basis of forestom-ach lesions. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =1140 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a683b140a1d0a6ac; raw_unit=mg/kg bw per day; context=The NOEL for citral was 1140 mg/kg bw per day in male rats on the basis of forestom-ach lesions. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =2280 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a5dc314ddc5afdb9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL for citral was 2280 mg/kg bw per day, the highest dose tested. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =2280 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a5dc314ddc5afdb9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL for citral was 2280 mg/kg bw per day, the highest dose tested. |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =4275 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2f7815776afef952; raw_unit=mg/kg bw per day; context=The NOEL for citral was 4275 mg/kg bw per day, on the basis of decreased body weights (Dieter et al., 1993). |
| INCHEM_WHO_jecfa_jecmono_v52je15 | NOEL | =4275 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2f7815776afef952; raw_unit=mg/kg bw per day; context=The NOEL for citral was 4275 mg/kg bw per day, on the basis of decreased body weights (Dieter et al., 1993). |
INCHEM_WHO_jecfa_jecmono_v52je28 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =2.06 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f38134d6d683c7cd; raw_unit=mg/kg bw per day; context=1284 ( E )-3,( Z )-6-Nonadien-1-ol 92% 6% ( E,E ) isomer In a 28-day study in rats, a NOEL* of 2.06 mg/kg bw per day was reported for the structurally related material ( E,Z )-2,6-dodecadienal (No. |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =2.06 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f38134d6d683c7cd; raw_unit=mg/kg bw per day; context=1284 ( E )-3,( Z )-6-Nonadien-1-ol 92% 6% ( E,E ) isomer In a 28-day study in rats, a NOEL* of 2.06 mg/kg bw per day was reported for the structurally related material ( E,Z )-2,6-dodecadienal (No. |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =10 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=7aa3e892bfacc240; raw_unit=mg/kg bw per day; context=A NOEL of 10 mg/kg bw per day was reported for the structurally related substance, beta- ionone (No. |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =10 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=7aa3e892bfacc240; raw_unit=mg/kg bw per day; context=A NOEL of 10 mg/kg bw per day was reported for the structurally related substance, beta- ionone (No. |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =30 | mg/kg bw/day | Rat | oral | 13-week | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=13cce56a91464508; raw_unit=mg/kg bw per day; context=A 13-week study of oral administration in rats identified a NOEL of 30 mg/kg bw per day for this material (Gaunt, 1971). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =30 | mg/kg bw/day | Rat | oral | 13-week | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=13cce56a91464508; raw_unit=mg/kg bw per day; context=A 13-week study of oral administration in rats identified a NOEL of 30 mg/kg bw per day for this material (Gaunt, 1971). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =32 | mg/kg bw/day | Mouse | - | 80-week | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=9a42cdc9dd4795ad; raw_unit=mg/kg bw per day; context=In an 80-week study in mice a NOEL of 32 mg/kg bw per day was reported (Roe et al., 1979). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =32 | mg/kg bw/day | Mouse | - | 80-week | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=9a42cdc9dd4795ad; raw_unit=mg/kg bw per day; context=In an 80-week study in mice a NOEL of 32 mg/kg bw per day was reported (Roe et al., 1979). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >50 | mg/kg bw/day | Rat | - | 84-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f82c7ce96269f31c; raw_unit=mg/kg bw per day; context=In an 84-day study in rats, the NOEL for linalool was >50 mg/kg bw per day (Oser, 1967). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >50 | mg/kg bw/day | Rat | - | 84-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f82c7ce96269f31c; raw_unit=mg/kg bw per day; context=In an 84-day study in rats, the NOEL for linalool was >50 mg/kg bw per day (Oser, 1967). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =60 | mg/kg bw | Rat | - | 98-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=749ac57fbe6bd49a; raw_unit=mg/kg bw; context=A 98-day study with the structurally related material 2,4-hexadienal showed a NOEL of 15 and 60 mg/kg bw for male and female rats, respectively (National Toxicology Program, 2001b). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =60 | mg/kg bw | Rat | - | 98-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=749ac57fbe6bd49a; raw_unit=mg/kg bw; context=A 98-day study with the structurally related material 2,4-hexadienal showed a NOEL of 15 and 60 mg/kg bw for male and female rats, respectively (National Toxicology Program, 2001b). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =100 | mg/kg bw/day | - | - | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=2c502db7cb4d2e65; raw_unit=mg/kg bw per day; context=A 90-day study for the structurally related material (E,E)-2,4-decadienal identified a NOEL of 100 mg/kg bw per day (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =100 | mg/kg bw/day | - | - | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=2c502db7cb4d2e65; raw_unit=mg/kg bw per day; context=A 90-day study for the structurally related material (E,E)-2,4-decadienal identified a NOEL of 100 mg/kg bw per day (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | range:120-150150 | mg/kg bw/day | - | oral | 98-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=b3dcd4e63287f3b5; raw_unit=mg/kg bw per day; context=A NOEL of 120-150 mg/kg bw per day was reported for cis -3-hexen-1-ol in a 98-day study of oral administration (Gaunt et al., 1969). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | range:120-150150 | mg/kg bw/day | - | oral | 98-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=b3dcd4e63287f3b5; raw_unit=mg/kg bw per day; context=A NOEL of 120-150 mg/kg bw per day was reported for cis -3-hexen-1-ol in a 98-day study of oral administration (Gaunt et al., 1969). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =250 | mg/kg bw/day | Rat | oral | 14-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=0b22922f8269a615; raw_unit=mg/kg bw per day; context=In a 14-day study of oral toxicity in rats, isopulegol was reported to have a NOEL of 250 mg/kg bw per day (Imaizumi et al., 1985). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =250 | mg/kg bw/day | Rat | oral | 14-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=0b22922f8269a615; raw_unit=mg/kg bw per day; context=In a 14-day study of oral toxicity in rats, isopulegol was reported to have a NOEL of 250 mg/kg bw per day (Imaizumi et al., 1985). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =350 | mg/kg bw/day | Rat | - | 63-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=6992895be58d3f53; raw_unit=mg/kg bw per day; context=In a 63-day study in rats, the NOEL for acetic acid was 350 mg/kg bw per day (Pardoe, 1952). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =350 | mg/kg bw/day | Rat | - | 63-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=6992895be58d3f53; raw_unit=mg/kg bw per day; context=In a 63-day study in rats, the NOEL for acetic acid was 350 mg/kg bw per day (Pardoe, 1952). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >400 | mg/kg bw/day | Rat | - | 2-year | Chronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=74fe4d87763b5af8; raw_unit=mg/kg bw per day; context=A NOEL of >400 mg/kg bw per day for formic acid was identified in a 2-year study in rats (Malorny, 1969). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >400 | mg/kg bw/day | Rat | - | 2-year | Chronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=74fe4d87763b5af8; raw_unit=mg/kg bw per day; context=A NOEL of >400 mg/kg bw per day for formic acid was identified in a 2-year study in rats (Malorny, 1969). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =1200 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=3a43923bf1e999db; raw_unit=mg/kg bw per day; context=In a 28-day study in rats, the NOEL for 1,8-cineole was 300 and 1200 mg/kg bw per day for males and females, respectively (National Toxicology Program, 1987a). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =1200 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=3a43923bf1e999db; raw_unit=mg/kg bw per day; context=In a 28-day study in rats, the NOEL for 1,8-cineole was 300 and 1200 mg/kg bw per day for males and females, respectively (National Toxicology Program, 1987a). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =2000 | mg/kg bw/day | Rat | - | 2 years | Chronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=369130f62ca03842; raw_unit=mg/kg bw per day; context=A NOEL of 2000 mg/kg bw per day was reported when rats were fed a mixture of 71% geranyl acetate and 29% citronellyl acetate for 2 years (National Toxicology Program, 1987b). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | =2000 | mg/kg bw/day | Rat | - | 2 years | Chronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=369130f62ca03842; raw_unit=mg/kg bw per day; context=A NOEL of 2000 mg/kg bw per day was reported when rats were fed a mixture of 71% geranyl acetate and 29% citronellyl acetate for 2 years (National Toxicology Program, 1987b). |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >2500 | mg/kg bw/day | Rat | oral | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=011f2107208f490a; raw_unit=mg/kg bw per day; context=A 90-day study of oral administration in rats identified a NOEL of >2500 mg/kg bw per day for the structurally related material, isovaleric acid (No. |
| INCHEM_WHO_jecfa_jecmono_v52je28 | NOEL | >2500 | mg/kg bw/day | Rat | oral | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=011f2107208f490a; raw_unit=mg/kg bw per day; context=A 90-day study of oral administration in rats identified a NOEL of >2500 mg/kg bw per day for the structurally related material, isovaleric acid (No. |
NTP_ICE_acute_oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4895 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Pesticide Active Ingredients Database (undated); record_id=acute_oral_7349; row=10349; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4950 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7351; row=10347; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4960 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7355; row=10350; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =6800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7357; row=10348; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | POLY-3 lowest dose | 1000 | ppm | Mouse | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=7004; Record_ID=cancer_2063; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=1000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Hematopoietic system; Lesion=Malignant lymphoma: histiocytic, lymphocytic, mixed, nos, or undifferentiated cell type; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_cancer | Top dose | 2000 | ppm | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7000; Record_ID=cancer_2060; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_cancer | Top dose | 4000 | ppm | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7007; Record_ID=cancer_2065; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=3028; RecordID=ARPathway2016_1297; DatasetName=ARPathway2016; DTXSID=DTXSID6024836; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
NTP_ICE_skin_sensitization 156 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 13 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2503; Record_ID=skin_sensitization_invitro_593; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=13; Reported_Response_Unit=ug/mL; Response=13; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 15 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2186; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=15; Reported_Response_Unit=ug/mL; Response=15; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 2.2 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8239; Record_ID=skin_sensitization_invitro_2262; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=14.45181633; Reported_Response_Unit=uM; Conversion_Factor_Value=152.237; Conversion_Factor_Source=EPA Dashboard; Converted_Response=2.2; Converted_Response_Unit=ug/mL; Response=2.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 3.7 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8586; Record_ID=skin_sensitization_invitro_2371; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=3.7; Reported_Response_Unit=ug/mL; Response=3.7; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 8.41 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2184; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=8.41; Reported_Response_Unit=ug/mL; Response=8.41; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CV70 | 12.97 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8585; Record_ID=skin_sensitization_invitro_2371; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CV70; Reported_Response=12.97; Reported_Response_Unit=ug/mL; Response=12.97; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CV75 | 16.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2508; Record_ID=skin_sensitization_invitro_593; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CV75; Reported_Response=16.600000000000001; Reported_Response_Unit=ug/mL; Response=16.6; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | CV75 | 24 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2188; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CV75; Reported_Response=24; Reported_Response_Unit=ug/mL; Response=24; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 0.04167 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7857; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.04167; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 0.125 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7841; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 0.3125 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7872; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 0.4 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7960; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | range0.42 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7909; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=0.42 - 0.84; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 0.7656 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7886; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.7656; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 1.025 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7923; Record_ID=skin_sensitization_invivo_1787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.025; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 1.2 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7881; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.2; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 2.1 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7906; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 3.733 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7893; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.733; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.03333 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7853; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.03333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.1 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7837; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | range0.2 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7905; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response_Modifier=range; Response=0.2 - 0.4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7869; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.3125 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7885; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7904; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 0.8 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7956; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 1 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7879; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 1.333 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7891; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=1.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Cys | 13.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=384; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=13.9; Reported_Response_Unit=%; Response=13.9; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Cys | 78.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=374; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=78.599999999999994; Reported_Response_Unit=%; Response=78.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Cys | 85.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=380; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=85.7; Reported_Response_Unit=%; Response=85.7; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys | 8.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=373; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=8.6; Reported_Response_Unit=%; Response=8.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys | 16.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=379; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=16.899999999999999; Reported_Response_Unit=%; Response=16.9; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys | 19.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=383; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=19.600000000000001; Reported_Response_Unit=%; Response=19.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 14 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=385; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=14; Reported_Response_Unit=%; Response=14; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 43.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=376; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=43.6; Reported_Response_Unit=%; Response=43.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 51.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=381; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=51.3; Reported_Response_Unit=%; Response=51.3; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 6.75 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5931; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.75; Reported_Response_Unit=uM; Response=6.75; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 7.66 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5932; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.66; Reported_Response_Unit=uM; Response=7.66; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 12.6 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5908; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=12.6; Reported_Response_Unit=uM; Response=12.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 13.46 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5909; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.46; Reported_Response_Unit=uM; Response=13.46; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 14.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5910; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.8; Reported_Response_Unit=uM; Response=14.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 15.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5911; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.3; Reported_Response_Unit=uM; Response=15.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 16.1 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5912; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.100000000000001; Reported_Response_Unit=uM; Response=16.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 16.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5913; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.3; Reported_Response_Unit=uM; Response=16.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 16.37 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5914; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.37; Reported_Response_Unit=uM; Response=16.37; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 16.91 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5915; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.91; Reported_Response_Unit=uM; Response=16.91; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 17 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5916; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17; Reported_Response_Unit=uM; Response=17; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 17.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5917; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.2; Reported_Response_Unit=uM; Response=17.2; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 17.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5918; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.3; Reported_Response_Unit=uM; Response=17.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 17.33 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5919; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.329999999999998; Reported_Response_Unit=uM; Response=17.33; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 18.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5920; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.3; Reported_Response_Unit=uM; Response=18.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 18.46 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5921; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.46; Reported_Response_Unit=uM; Response=18.46; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 19.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5922; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=19.2; Reported_Response_Unit=uM; Response=19.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 20.4 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5923; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=20.399999999999999; Reported_Response_Unit=uM; Response=20.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 21.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5924; Record_ID=skin_sensitization_invitro_1389; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=21.2; Reported_Response_Unit=uM; Response=21.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 22.66 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5925; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=22.66; Reported_Response_Unit=uM; Response=22.66; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 23.16 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5926; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.164999999999999; Reported_Response_Unit=uM; Response=23.16; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 23.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5927; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.2; Reported_Response_Unit=uM; Response=23.2; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 23.88 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5928; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.88; Reported_Response_Unit=uM; Response=23.88; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 25.1 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5929; Record_ID=skin_sensitization_invitro_1390; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=25.1; Reported_Response_Unit=uM; Response=25.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | 34.37 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5930; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=34.369999999999997; Reported_Response_Unit=uM; Response=34.37; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC1.5 | <48.23 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7595; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=48.23; Reported_Response_Unit=uM; Response=48.23; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 4.6 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12938; Record_ID=skin_sensitization_invivo_2867; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=4.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 5.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13138; Record_ID=skin_sensitization_invivo_3155; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ashby et al. 1995; 8553361; 10.1016/0300-483x(95)03132-y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 5.3 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12940; Record_ID=skin_sensitization_invivo_2867; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 5.7 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13135; Record_ID=skin_sensitization_invivo_3151; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 6.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13072; Record_ID=skin_sensitization_invivo_3057; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 6.6 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13130; Record_ID=skin_sensitization_invivo_3144; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=6.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 9.2 | % | Mouse | Dermal | - | In Vivo; LLNA2013; LLNA | sheet=Data_invivo; excel_row=12877; Record_ID=skin_sensitization_invivo_493; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=9.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 12 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13132; Record_ID=skin_sensitization_invivo_3146; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=12; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 12.6 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13136; Record_ID=skin_sensitization_invivo_3153; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=12.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 13 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13127; Record_ID=skin_sensitization_invivo_3141; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=13; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | EC3 | 67.36 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5933; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=67.361999999999995; Reported_Response_Unit=uM; Response=67.36; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 100.29 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5934; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=100.29; Reported_Response_Unit=uM; Response=100.29; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 102.77 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5935; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=102.77; Reported_Response_Unit=uM; Response=102.77; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 103.5 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5936; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=103.5; Reported_Response_Unit=uM; Response=103.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 107.67 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5937; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=107.67; Reported_Response_Unit=uM; Response=107.67; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 113.87 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5938; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=113.87; Reported_Response_Unit=uM; Response=113.87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | >120 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7665; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=120; Reported_Response_Unit=uM; Response=120; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 122.19 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5939; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=122.19; Reported_Response_Unit=uM; Response=122.19; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 156.01 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5940; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=156.01; Reported_Response_Unit=uM; Response=156.01; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 159.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5941; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=159.30000000000001; Reported_Response_Unit=uM; Response=159.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 166.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5942; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=166.9; Reported_Response_Unit=uM; Response=166.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 167.99 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5943; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=167.99; Reported_Response_Unit=uM; Response=167.99; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 170.91 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5944; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=170.91; Reported_Response_Unit=uM; Response=170.91; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 171.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5945; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=171.8; Reported_Response_Unit=uM; Response=171.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 177.25 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5946; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=177.25; Reported_Response_Unit=uM; Response=177.25; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 182.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5947; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=182.8; Reported_Response_Unit=uM; Response=182.8; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 182.81 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5948; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=182.81; Reported_Response_Unit=uM; Response=182.81; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 193.55 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5949; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=193.55; Reported_Response_Unit=uM; Response=193.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 207.4 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5950; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=207.4; Reported_Response_Unit=uM; Response=207.4; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 209.89 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5951; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=209.89; Reported_Response_Unit=uM; Response=209.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 212.06 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5952; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=212.06; Reported_Response_Unit=uM; Response=212.06; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 226.64 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5953; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=226.64; Reported_Response_Unit=uM; Response=226.64; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 238.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5954; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=238.8; Reported_Response_Unit=uM; Response=238.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 241 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5955; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=241; Reported_Response_Unit=uM; Response=241; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | IC50 | 249.47 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5956; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=249.47; Reported_Response_Unit=uM; Response=249.47; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 9.534 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5990; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.5340000000000007; Reported_Response_Unit=Unitless; Response=9.534; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 10.426 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5957; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=10.426; Reported_Response_Unit=Unitless; Response=10.426; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 16.381 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5963; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.381; Reported_Response_Unit=Unitless; Response=16.381; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 22.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5965; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.3; Reported_Response_Unit=Unitless; Response=22.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 23.72 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5967; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.716000000000001; Reported_Response_Unit=Unitless; Response=23.72; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 32.32 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7568; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=Imax; Reported_Response=32.32188705; Reported_Response_Unit=Unitless; Response=32.32; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 35.86 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5969; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=35.86; Reported_Response_Unit=Unitless; Response=35.86; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 38.59 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5971; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=38.591000000000001; Reported_Response_Unit=Unitless; Response=38.59; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 40 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5973; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=40; Reported_Response_Unit=Unitless; Response=40; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 41.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5975; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=41.103000000000002; Reported_Response_Unit=Unitless; Response=41.1; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 50.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5977; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=50.2; Reported_Response_Unit=Unitless; Response=50.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 50.84 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5979; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=50.835000000000001; Reported_Response_Unit=Unitless; Response=50.84; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 51.59 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5981; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=51.591999999999999; Reported_Response_Unit=Unitless; Response=51.59; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 59.91 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5983; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=59.911000000000001; Reported_Response_Unit=Unitless; Response=59.91; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 60.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5985; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=60.2; Reported_Response_Unit=Unitless; Response=60.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 76.96 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5987; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=76.959999999999994; Reported_Response_Unit=Unitless; Response=76.96; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 84.55 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5988; Record_ID=skin_sensitization_invitro_1390; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=84.55; Reported_Response_Unit=Unitless; Response=84.55; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 85.78 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5989; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=85.775999999999996; Reported_Response_Unit=Unitless; Response=85.78; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 93.89 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5991; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=93.894000000000005; Reported_Response_Unit=Unitless; Response=93.89; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 96.4 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5993; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=96.4; Reported_Response_Unit=Unitless; Response=96.4; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 96.42 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5995; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=96.42; Reported_Response_Unit=Unitless; Response=96.42; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 103.571 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5958; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=103.571; Reported_Response_Unit=Unitless; Response=103.571; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 104.4 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5959; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=104.4; Reported_Response_Unit=Unitless; Response=104.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 107.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5960; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=107.3; Reported_Response_Unit=Unitless; Response=107.3; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 108.277 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5961; Record_ID=skin_sensitization_invitro_1389; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=108.277; Reported_Response_Unit=Unitless; Response=108.277; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Imax | 132.8 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5962; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=132.81800000000001; Reported_Response_Unit=Unitless; Response=132.8; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7894; Record_ID=skin_sensitization_invivo_1782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 2.381 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7900; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.381; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 4 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7833; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 8 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7865; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 8.333 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7877; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 9.756 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7918; Record_ID=skin_sensitization_invivo_1787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=9.756; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 10.71 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7889; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=10.71; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 12 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7849; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=12; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 32.65 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7966; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=32.65; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 47.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7901; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=47.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 50 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7952; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=50; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 64.8 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7831; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=64.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 324 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7863; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=324; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 775 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7910; Record_ID=skin_sensitization_invivo_1785; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1296 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7876; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | range3100 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7899; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response_Modifier=range; Response=3100 - 6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6200 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7888; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 27 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7859; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=27; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 81 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7843; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=81; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 202.5 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7874; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=202.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 310 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7962; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=310; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | range326 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7911; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=326 - 652; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 777.6 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7882; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=777.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 2893 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7895; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2893; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 21.6 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7855; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=21.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 162 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7871; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=162; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | range163 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7907; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response_Modifier=range; Response=163 - 326; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 620 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7958; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=620; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 648 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7880; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 1033 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7892; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=1033; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Max stimulation index | 20.5 | ratio | Mouse | Dermal | - | In Vivo; LLNA2013; LLNA | sheet=Data_invivo; excel_row=12876; Record_ID=skin_sensitization_invivo_493; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=Max stimulation index; Response=20.5; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7845; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
| NTP_ICE_skin_sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7887; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836 |
SCCS_vision_codex 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS_vision_codex | NOAEL | =3 | µg/cm2 | human | - | - | sensitisation | {"dose":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...","effect":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250","page":60,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_007"} |
| SCCS_vision_codex | NOAEL | =3 | µg/cm2 | human | - | - | sensitisation | {"dose":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...","effect":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250","page":60,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_007"} |
| SCCS_vision_codex | NOAEL | =3 | µg/cm2 | human | - | - | sensitisation | {"dose":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...","effect":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250","page":60,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_007"} |
| SCCS_vision_codex | NOAEL | =3 | µg/cm2 | human | - | - | sensitisation | {"dose":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...","effect":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250","page":60,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_007"} |
| SCCS_vision_codex | NOAEL | =61 | - | human | - | - | sensitisation | {"effect":"Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_009"} |
| SCCS_vision_codex | NOAEL | =61 | - | human | - | - | sensitisation | {"effect":"Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_009"} |
| SCCS_vision_codex | NOAEL | =61 | - | human | - | - | sensitisation | {"effect":"Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_009"} |
| SCCS_vision_codex | NOAEL | =61 | - | human | - | - | sensitisation | {"effect":"Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_009"} |
| SCCS_vision_codex | NOAEL | =500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_010"} |
| SCCS_vision_codex | NOAEL | =500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_010"} |
| SCCS_vision_codex | NOAEL | =500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_010"} |
| SCCS_vision_codex | NOAEL | =500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_010"} |
| SCCS_vision_codex | NOAEL | =1400 | µg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_002"} |
| SCCS_vision_codex | NOAEL | =1400 | µg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_002"} |
| SCCS_vision_codex | NOAEL | =1400 | µg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_002"} |
| SCCS_vision_codex | NOAEL | =1400 | µg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_002"} |
| SCCS_vision_codex | NOAEL | =1417 | μg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_001"} |
| SCCS_vision_codex | NOAEL | =1417 | μg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_001"} |
| SCCS_vision_codex | NOAEL | =1417 | μg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_001"} |
| SCCS_vision_codex | NOAEL | =1417 | μg/cm2 | human | - | - | sensitisation | {"dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","effect":"these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit","page":18,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_001"} |
| SCCS_vision_codex | NOAEL | =1666 | - | guinea pig | - | - | sensitisation | {"effect":"SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_008"} |
| SCCS_vision_codex | NOAEL | =1666 | - | guinea pig | - | - | sensitisation | {"effect":"SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_008"} |
| SCCS_vision_codex | NOAEL | =1666 | - | guinea pig | - | - | sensitisation | {"effect":"SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_008"} |
| SCCS_vision_codex | NOAEL | =1666 | - | guinea pig | - | - | sensitisation | {"effect":"SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_008"} |
| SCCS_vision_codex | NOAEL | >2500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_011"} |
| SCCS_vision_codex | NOAEL | >2500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_011"} |
| SCCS_vision_codex | NOAEL | >2500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_011"} |
| SCCS_vision_codex | NOAEL | >2500 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_011"} |
| SCCS_vision_codex | NOAEL | =3448 | μg/cm2 | human | dermal | - | sensitisation | {"dose":"There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.","effect":"ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu","page":19,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_004"} |
| SCCS_vision_codex | NOAEL | =3448 | μg/cm2 | human | dermal | - | sensitisation | {"dose":"There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.","effect":"ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu","page":19,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_004"} |
| SCCS_vision_codex | NOAEL | =3448 | μg/cm2 | human | dermal | - | sensitisation | {"dose":"There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.","effect":"ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu","page":19,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_004"} |
| SCCS_vision_codex | NOAEL | =3448 | μg/cm2 | human | dermal | - | sensitisation | {"dose":"There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.","effect":"ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu","page":19,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_004"} |
| SCCS_vision_codex | NOAEL | >10000 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Extremely weak | > 10,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_012"} |
| SCCS_vision_codex | NOAEL | >10000 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Extremely weak | > 10,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_012"} |
| SCCS_vision_codex | NOAEL | >10000 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Extremely weak | > 10,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_012"} |
| SCCS_vision_codex | NOAEL | >10000 | - | - | - | - | NOAEL study | {"effect":"Unlabeled table on page 61: Extremely weak | > 10,000","page":61,"pdf":"sccs_o_287.pdf","row_type":"noael_study","study_id":"sccs_o_287_noael_012"} |
ToxRefDB_ToxRefDB_v3_pod.csv 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =60 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5254; toxval_study_source_id=studyid5254_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-mineralization|in life observation-body weight-body weight|pathology microscopic-bone-fibrosis|pathology gross-full gross necropsy-lymphoma malignant|pathology microscopic-kidney-nephropathy; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =120 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5254; toxval_study_source_id=studyid5254_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-adrenal gland-hyperplasia; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =210 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-adrenal gland-angiectasis|in life observation-body weight-body weight; dose_level=3; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =335 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-bone marrow-atrophy|in life observation-food consumption-food consumption|in life observation-clinical signs-[other]|pathology microscopic-bone marrow-hemorrhage|in life observation-clinical signs-impaired reflex, nos|in life observation-clinical signs-hunched posture|in life observation-mortality-mortality|pathology microscopic-stomach-hyperkeratosis|in life observation-clinical signs-lethargy|pathology microscopic-stomach-hyperplasia|pathology microscopic-thymus-atrophy; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =345 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-kidney-nephropathy|pathology microscopic-stomach-hyperkeratosis|in life observation-clinical signs-[other]|pathology microscopic-bone marrow-atrophy|in life observation-mortality-mortality|in life observation-clinical signs-lethargy|in life observation-clinical signs-hunched posture|in life observation-clinical signs-impaired reflex, nos|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption|pathology microscopic-thymus-atrophy|pathology microscopic-testes-aspermia|pathology microscopic-bone marrow-hemorrhage; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =745 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5251; toxval_study_source_id=studyid5251_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|hematology-lymphocyte-lymphocyte|in life observation-mortality-mortality; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =790 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5251; toxval_study_source_id=studyid5251_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|pathology microscopic-ovary-atrophy|hematology-lymphocyte-lymphocyte; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =675 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =820 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|in life observation-mortality-mortality|pathology microscopic-bone marrow-atrophy|in life observation-clinical signs-hunched posture|in life observation-clinical signs-impaired reflex, nos|pathology microscopic-bone marrow-hemorrhage|in life observation-clinical signs-[other]|in life observation-body weight-body weight gain|pathology microscopic-thymus-atrophy|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption|in life observation-clinical signs-lethargy|in life observation-body weight-body weight; dose_level=0; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =50 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-mineralization|in life observation-body weight-body weight; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-adrenal gland-angiectasis; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =20 | % | Mouse | dermal | short-term; 16 days | short-term | LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608174:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=651e9a260ec697c4c205fe85483059d4 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =345 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15621848:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46bea94eb298cd089c84e427b3f032c4 |
ToxValDB_EPA_TSCA_8e 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | NEL | =200 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 23 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20502_2155_C.pdf; TOXICOLOGICAL_EFFECT=F1: no evidence of selective developmental toxicity; STUDY_GROUP=EPA TSCA 8e:15956451:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e6e1be54fc0f04d5fb79e1aa745034d |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =9 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630737:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d86a625c047a2fd5602673ea1a8ae3e3 |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <335 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df3e4b0a676289de9dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Blood Chemistry: BUN increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=HESS:15638949:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea956633d7bbb69c53c9112d1bef222d |
ToxValDB_ToxRefDB 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =60 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5254; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-bone-fibrosis|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-mineralization|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology gross-full gross necropsy-lymphoma malignant; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708827_15708828:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f70ed96a04e19e0e4cacc173a05ccb63 |
| ToxValDB_ToxRefDB | LEL | =120 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5254; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-adrenal gland-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708829_15708830:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c69543d52f6f2b0e7f38ed5fba7de30 |
| ToxValDB_ToxRefDB | LEL | =210 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708821_15708822_15708823_15708824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9a0b1b779c37faf514f983b1b738ef9 |
| ToxValDB_ToxRefDB | LEL | =745 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5251; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: hematology-lymphocyte-lymphocyte|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15708819_15708820:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1c0aa46b7225a4120541b5e160e9ca7 |
| ToxValDB_ToxRefDB | LEL | =790 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5251; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: hematology-lymphocyte-lymphocyte|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: pathology microscopic-ovary-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708817_15708818:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d3e8fbc74d61f74d0f5abe75ffa4870 |
| ToxValDB_ToxRefDB | LOAEL | =675 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5248; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708811_15708812_15708813:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_064d8db124cb322170df4b54f7acb260 |
| ToxValDB_ToxRefDB | LOAEL | =820 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5248; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708814_15708815_15708816:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8746bd639e3fab44baa7f28bef81afcc |
| ToxValDB_ToxRefDB | NEL | =50 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-mineralization|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708825_15708826:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58821f43841f14a0ae3f8bc59977fe3e |
| ToxValDB_ToxRefDB | NEL | =100 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708821_15708822_15708823_15708824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc08b79a3ec8ff00a273558708ec8fef |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=0.5 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af4bee4b0d99f5a872920; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3485; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=WHO JECFA ADI:15715255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af88f8ad7f485fbcb6f2ef8e9fa34054 |
UnifiedCodex:SCCS_SHADOW:beta.noael_studies 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | - | 500 | - | - | - | - | - | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=500 – 2500; EFFECT=Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"Unlabeled table on page 61: Moderate | 500 – 2500 | 250 - < 2500","endpoint":"","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"","noael_value":"500 – 2500","page":61,"route":"","species":"","study_id":"sccs_o_287_noael_010"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | - | >2500 | - | - | - | - | - | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=>2500 - 10,000; EFFECT=Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"Unlabeled table on page 61: Weak | >2500 - 10,000 | 2500 - 25,000","endpoint":"","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"","noael_value":">2500 - 10,000","page":61,"route":"","species":"","study_id":"sccs_o_287_noael_011"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | - | >10000 | - | - | - | - | - | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=> 10,000; EFFECT=Unlabeled table on page 61: Extremely weak | > 10,000; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"Unlabeled table on page 61: Extremely weak | > 10,000","endpoint":"","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"","noael_value":"> 10,000","page":61,"route":"","species":"","study_id":"sccs_o_287_noael_012"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 3 | µg/cm2 | human | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=3; DOSE=EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...; EFFECT=EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Ta...","duration":"","effect":"EC3 µg/cm2 EC3 (%) EC3 µg/cm2 Extreme ≤ 0.2 ≤ 50 < 0.1 < 25 Strong > 0.2 - ≤ 2.0 > 50 - ≤ 500 ≥ 0.1 - < 1.0 ≥ 25 - < 250 Moderate > 2 > 500 ≥ 1.0 - < 10 ≥ 250 - < 2500 Weak - - ≥ 10 - ≤ 100 ≥ 2500 - ≤ 25,000 Na et al., (2022a) published dose ranges that can be assigned to potency categories based on human data (HRIPT/HMT) and LLNA EC3 values (Table 5). The ranges assigned to LLNA EC3 values align with those of ECETOC (2003) and Kimber et al., (2003). Table A.2: Potency category dose ranges Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Extreme < 25 < 25 Strong 25 – 500 25 - < 250","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"µg/cm2","noael_value":"3","page":60,"route":"","species":"human","study_id":"sccs_o_287_noael_007"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 61 | - | human | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=unclear:Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2); EFFECT=Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2); CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"","noael_value":"unclear:Unlabeled table on page 61: Potency Category | Human NOEL (HRIPT/HMT) (µg/cm2) | LLNA EC3 (µg/cm2)","page":61,"route":"","species":"human","study_id":"sccs_o_287_noael_009"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1400 | µg/cm2 | human | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=1400; DOSE=Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.; EFFECT=s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","duration":"","effect":"s (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insuff","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"µg/cm2","noael_value":"1400","page":18,"route":"","species":"human","study_id":"sccs_o_287_noael_002"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1400 | µg/cm2 | human | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=1400; DOSE=Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.; EFFECT=ich the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insufficiently sized according to the current stand; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","duration":"","effect":"ich the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensitisation in healthy volunteers. Altogether in this dossier, five HRIPT studies have been performed, four of them are insufficiently sized according to the current stand","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"µg/cm2","noael_value":"1400","page":18,"route":"","species":"human","study_id":"sccs_o_287_noael_003"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1417 | μg/cm2 | human | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=1417; DOSE=Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.; EFFECT=these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2.","duration":"","effect":"these tests were not designed to predict potency classification. 3.3.1.2.3 Human studies Human repeat insult patch tests (HRIPTs) Five HRIPTs were performed, of which the detailed results are presented in Annex II. Table 2 below describes an overview of these studies, placed in order of induction dose expressed in μg/cm2. The first study presented in the text above (second in table), also the most recent and conducted fully according to the standard protocol with more than 100 volunteers, delivered the highest NOEL of 1417 μg/cm2. The only greater level tested (almost 3-fold higher) gave positive results. Accordingly, the highest NOEL was rounded down to deliver a pragmatic NOEL of 1400 µg/cm2. Table 2: Overview of five HRIPT studies with Citral SCCS comments on HRIPT studies The SCCS has expressed ethical concerns several times about conducting human skin sensitisation tests, including the HRIPT (SCCP, 2008; SCCS, 2015; SCCS, 2018). One of the concerns is that exposure levels used in the test may themselves cause sensit","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"μg/cm2","noael_value":"1417","page":18,"route":"","species":"human","study_id":"sccs_o_287_noael_001"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1417 | μg/cm2 | - | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=1417; EFFECT=t a level of spread of 2-3x above and below the mean is what is typically found. It has been demonstrated also that EC3 values show a good degree of correlation with HRIPT NOELs (Gerberick et al., 2001b; Griem et al., 2003; Schneider and Akkan, 2004; Basketter et al., 2005; Api et al., 2015). In one HRIPT, Citral induced sensitisation at an exposure of 3876 μg/cm2 in 5/8 subjects. No sensitisation was induced in the other four HRIPTs, with the NOELs ranging from 388 μg/cm2 to 1417 μg/cm2. There was no identifiable NOEL among the HMTs conducted with petrolatum vehicle as all tested concentrations resulted in the induction of skin sensitisation. The single HMT using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation. The HRIPT NOEL of 1417 μg/cm2 would be given precedence over the HMT data as the study was conducted in 101 volunteers according to standardized protocol following a published method and was well documented. The Buehler Test results and five of the six GPMTs support the classification of Cit; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"t a level of spread of 2-3x above and below the mean is what is typically found. It has been demonstrated also that EC3 values show a good degree of correlation with HRIPT NOELs (Gerberick et al., 2001b; Griem et al., 2003; Schneider and Akkan, 2004; Basketter et al., 2005; Api et al., 2015). In one HRIPT, Citral induced sensitisation at an exposure of 3876 μg/cm2 in 5/8 subjects. No sensitisation was induced in the other four HRIPTs, with the NOELs ranging from 388 μg/cm2 to 1417 μg/cm2. There was no identifiable NOEL among the HMTs conducted with petrolatum vehicle as all tested concentrations resulted in the induction of skin sensitisation. The single HMT using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation. The HRIPT NOEL of 1417 μg/cm2 would be given precedence over the HMT data as the study was conducted in 101 volunteers according to standardized protocol following a published method and was well documented. The Buehler Test results and five of the six GPMTs support the classification of Cit","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"μg/cm2","noael_value":"1417","page":34,"route":"","species":"","study_id":"sccs_o_287_noael_005"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1417 | μg/cm2 | - | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=1417; EFFECT=an, 2004; Basketter et al., 2005; Api et al., 2015). In one HRIPT, Citral induced sensitisation at an exposure of 3876 μg/cm2 in 5/8 subjects. No sensitisation was induced in the other four HRIPTs, with the NOELs ranging from 388 μg/cm2 to 1417 μg/cm2. There was no identifiable NOEL among the HMTs conducted with petrolatum vehicle as all tested concentrations resulted in the induction of skin sensitisation. The single HMT using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation. The HRIPT NOEL of 1417 μg/cm2 would be given precedence over the HMT data as the study was conducted in 101 volunteers according to standardized protocol following a published method and was well documented. The Buehler Test results and five of the six GPMTs support the classification of Citral as a weak skin sensitiser. One GPMT classified Citral as a moderate sensitiser. None of these studies were judged to require a revision to LLNA/HRIPT based NESIL. Given all the above, the weight of evidence leads to a NESIL of 1400 μg/c; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"an, 2004; Basketter et al., 2005; Api et al., 2015). In one HRIPT, Citral induced sensitisation at an exposure of 3876 μg/cm2 in 5/8 subjects. No sensitisation was induced in the other four HRIPTs, with the NOELs ranging from 388 μg/cm2 to 1417 μg/cm2. There was no identifiable NOEL among the HMTs conducted with petrolatum vehicle as all tested concentrations resulted in the induction of skin sensitisation. The single HMT using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation. The HRIPT NOEL of 1417 μg/cm2 would be given precedence over the HMT data as the study was conducted in 101 volunteers according to standardized protocol following a published method and was well documented. The Buehler Test results and five of the six GPMTs support the classification of Citral as a weak skin sensitiser. One GPMT classified Citral as a moderate sensitiser. None of these studies were judged to require a revision to LLNA/HRIPT based NESIL. Given all the above, the weight of evidence leads to a NESIL of 1400 μg/c","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"μg/cm2","noael_value":"1417","page":34,"route":"","species":"","study_id":"sccs_o_287_noael_006"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 1666 | - | guinea pig | - | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=unclear:SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ; EFFECT=SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"","duration":"","effect":"SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"","noael_value":"unclear:SCCS/1666/24 Final Opinion Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint _________________________________________________________________________________ 61 Potency Category Human NOEL (HRIPT/HMT) (µg/cm2) LLNA EC3 (µg/cm2) Moderate 500 – 2500 250 - < 2500 Weak >2500 - 10,000 2500 - 25,000 Extremely weak > 10,000 Non-sensitizer Negative Guinea pig tests, specifically the Guinea Pig Maximization Test (GPMT) and the Buehler test, were designed for the purpose of hazard identification. While they are not well suited for potency categorization, several schemes have been published that utilize the induction concentration and the incidence of positive responses to provide an estimate of the relativ","page":61,"route":"","species":"guinea pig","study_id":"sccs_o_287_noael_008"} |
| UnifiedCodex:SCCS_SHADOW:beta.noael_studies | sensitisation | 3448 | μg/cm2 | human | dermal | - | sensitisation | SOURCE_SUBDIR=sccs_o_287; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION on Citral (CAS No. 5392-40-5, EC No. 226-394-6) sensitisation endpoint; OPINION_NUMBER=SCCS/1666/24; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=final version of 29 July 2024; VALUE_TEXT=3448; DOSE=There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.; EFFECT=ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"5392-40-5","citation":"","dose":"There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency.","duration":"","effect":"ion with respect to relative sensitizing potency. Under the conditions of the Human Maximization test, Citral in petrolatum induced skin sensitisation at concentrations ranging from 8% (5517 μg/cm2) to 2% (1379 μg/cm2). Only the study using Citral at 5% (3448 μg/cm2) in butylene glycol failed to induce sensitisation in any of the 25 volunteers. Conclusion It was demonstrated that Citral has the potential to induce dermal sensitisation in humans. Except for the isolated study using butylene glycol as a vehicle, a NOEL was not demonstrated. There was only limited evidence of dose-response in the results, which, together with the intrinsic limitations of these assays already mentioned above, render it difficult to deduce information on potency. However, the trend of the data suggests a threshold around 0.5% - 1.0%, which, given the greater sensitivity of this assay compared to the HRIPT, but with the use of petrolatum as a vehicle (which was common at that time) suggests results consistent with the HRIPT. SCCS comments on the Hu","endpoint":"sensitisation","ingredient":"codes ............................................... 11","loael_value":"","noael_unit":"μg/cm2","noael_value":"3448","page":19,"route":"dermal","species":"human","study_id":"sccs_o_287_noael_004"} |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T7EU0O9VPP | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T7EU0O9VPP"} |
| openFDA substances | FDA UNII substance identifier | T7EU0O9VPP | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T7EU0O9VPP"} |
| openFDA substances | FDA UNII substance identifier | T7EU0O9VPP | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T7EU0O9VPP"} |
| openFDA substances | FDA UNII substance identifier | T7EU0O9VPP | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T7EU0O9VPP"} |