NOAEL Studies Fragrance

Citral NOAEL Studies

INCI: CITRAL

CAS: 5392-40-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 500 ppm mouse oral 105 week Chronic REACH;PAFA; Toxicol. Sci., 71, 198-206; 2003
COSMOS DB LOAEL 1000 ppm rat oral 105 week Chronic REACH;PAFA; Toxicol. Sci., 71, 198-206; 2003
COSMOS DB NOAEL 120 mg/kg bw/day mouse oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 125 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 210 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 534 mg/kg bw/day mouse oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 745 mg/kg bw/day mouse oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 820 mg/kg bw/day rat oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1140 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1500 mg/kg bw/day rat oral 5 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2280 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2400 mg/kg bw/day rat oral 10 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 8550 mg/kg bw/day mouse oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 345 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=f1622fee-a327-47d2-986f-6fdf20323add
ECHA LOAEL 335 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=798952db-73e1-49d9-82a0-d426d8c98a4f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=798952db-73e1-49d9-82a0-d426d8c98a4f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2bc30d85-9745-4afa-bcd9-6ffeb11c531b
ECHA LOAEL 210 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d66f3eb6-ffef-43b7-bd1a-4b71a0f99a81
ECHA LOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=89ae5ca4-2be3-43c9-ae06-0789b2dea0cb/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=c93f2316-b49d-4bbd-9d2e-190fed7ada41
ECHA LOAEL 745 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ac0809e6-35ac-4ff7-b40b-91776e408045
ECHA LOAEL 790 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=7a5905b2-93c1-4e44-b222-a87231877e2e_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=7a5905b2-93c1-4e44-b222-a87231877e2e/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d5dee5e-d4b3-439f-af3b-dc19b9b658f8
ECHA LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=06c9da77-bd84-4c95-9000-7123e1798b84_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=06c9da77-bd84-4c95-9000-7123e1798b84/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=61622051-d75d-4432-b088-18576997e955
ECHA LOAEL 1140 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=03da6358-9305-413f-bbe2-87a6bae07787
ECHA LOAEL 8850 mg/kg bw/day mouse oral: feed - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=06ca5b3f-5339-461c-80e1-22b48bb4d9b4
ECHA LOAEL 1068 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=5670a079-f1a7-4a59-b83d-1d1991b931ac
ECHA NOAEL 25 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=7edb035c-dacb-4e4b-90cb-91899f7e8e74
ECHA NOAEL 250 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=ec677cc6-4556-4dcd-80c7-947e311eae4b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=ec677cc6-4556-4dcd-80c7-947e311eae4b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-04-30; basis=other:; key_result=false; entry_uuid=43dcf060-5148-4495-b2ab-ab08800667b1
ECHA NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=f883dd97-b2af-4c04-b04b-716403180356_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=f883dd97-b2af-4c04-b04b-716403180356/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=6d334f34-392c-4821-bc9c-1b1e257a26ba
ECHA NOAEL 60 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=bc45b05a-be0e-4727-b215-32651d4aab1c_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=bc45b05a-be0e-4727-b215-32651d4aab1c/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f
ECHA NOAEL 200 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=c8679084-da2f-40a6-9c6f-e8842d08af4d
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=67074313-497d-4c4b-8d8e-69168153e76b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=67074313-497d-4c4b-8d8e-69168153e76b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=ab99bdc4-dfef-439a-9fc2-aacefea4e1ce
ECHA NOAEL 570 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=5be0e470-c923-46fc-b774-f0f28d6ff51f_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=5be0e470-c923-46fc-b774-f0f28d6ff51f/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=304c9167-bf81-4172-9064-306e5a92b451
ECHA NOAEL 1140 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=b843c4d2-c0e5-4fa5-8001-a53fe28249be
ECHA NOAEL 4275 mg/kg bw/day mouse oral: feed - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=884e5426-d232-4653-8294-99000c464d7b_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=884e5426-d232-4653-8294-99000c464d7b/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=94b89980-06a1-45a7-b765-282b9dab75bd
ECHA NOAEL 534 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=1e03d706-2e21-49f9-af01-f84c4777afbc_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=1e03d706-2e21-49f9-af01-f84c4777afbc/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=149fb423-1213-4453-9cf9-8a601b1a7a74
ECHA NOEL 2280 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=f41a0d17-2971-4f89-9c27-d3145a15c959.i6z; document=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac_f41a0d17-2971-4f89-9c27-d3145a15c959.i6d; document_key=be9e88aa-aeef-4cbf-84ad-bfedc7ba1fac/f41a0d17-2971-4f89-9c27-d3145a15c959; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=other:; key_result=false; entry_uuid=6cc07cdb-5de9-4678-93e7-af791cbe497b
EFSA 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =6 mg/kg bw Unspecified - - other EFSA CEF - 2010 - OutputID 2050 - Scientific Opinion on Flavouring Group Evaluation 72 (FGE.72): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids. Esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010). - doi:10.2903/j.efsa.2010.1402
EFSA NOAEL =60 mg/kg bw Unspecified - - other EFSA CEF - 2013 - OutputID 2375 - Scientific Opinion on Flavouring Group Evaluation 72, Revision 1 (FGE.72Rev1): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids, esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2013.3392
EFSA NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
EFSA ADI (group) =0.5 mg/kg bw/day Consumers - - ADI (group) EFSA FEEDAP - 2011 - OutputID 248 - Consumers - Scientific Opinion on the safety and efficacy of FRESTA F for weaned piglets - doi:10.2903/j.efsa.2011.2139
EFSA NOAEL =345 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15621848:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46bea94eb298cd089c84e427b3f032c4
WHO/JECFA 35 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI ~0.15 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=357b7ff77ce81248; raw_unit=mg/kg bw; context=It was also noted that even the total combined daily intake of all 32 flavouring agents under evaluation (approximately 0.15 mg/kg bw in Europe and the USA) is less than the group ADI.
WHO/JECFA ADI =0.5 mg/kg bw/day - - short-term Health guidance value document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b712630060595c84; raw_unit=mg/kg bw; context=A group ADI of 0–0.5 mg/kg bw, expressed as citral, was established for citral, geranyl acetate, citronellol, linalool, and linalyl acetate on the basis of their clearly-defined metabolism, rapid excretion, and low toxicity in short-term studies.
WHO/JECFA NOEL =1.36 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=986eb772a3803866; raw_unit=mg/kg bw per day; context=The NOEL for 2,4-dimethyl-2-pentenoic acid was 1.36 mg/kg bw per day in male rats and 1.55 mg/kg bw per day in female rats, the highest dose tested (Posternak, 1968). (iii) dl-Citronellol (No.
WHO/JECFA NOEL =50 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=df1d5b3a050ce928; raw_unit=mg/kg bw per day; context=The NOEL for citral was 50 mg/kg bw per day for maternal toxicity and 160 mg/kg bw per day for developmental toxicity (Hoberman et al., 1989).
WHO/JECFA NOEL =51 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=81bd93ff31018159; raw_unit=mg/kg bw per day; context=The NOEL for citronellol was 51 mg/kg bw per day in male rats and 56 mg/kg bw per day in female rats, the highest dose tested (Oser, 1958b). (iv) Geraniol (No.
WHO/JECFA NOEL =52 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2a560ce688631c4e; raw_unit=mg/kg bw per day; context=The NOEL for citral was 52 mg/kg bw per day for male rats and 60 mg/kg bw per day for female rats, the highest dose tested (Oser, 1958a).
WHO/JECFA NOEL =60 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=9521f717efae07ee; raw_unit=mg/kg bw per day; context=The NOEL of 60 mg/kg bw per day (National Toxicology Program, 2003) for citral is >500 times more than the estimated daily intakes of 114 mg/kg bw in Europe and 117 mg/kg bw in the USA when used a flavouring agent See note 4 * 8-Ocimenyl acetate 1226 197098-61-6 No Europe:
WHO/JECFA NOEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=e8479535bdfe79db; raw_unit=mg/kg bw per day; context=The NOEL for citral was 100 mg/kg bw per day on the basis of decreased body weights (in particular in females) (National Toxicology Program, 2003). (d) Genotoxicity Testing for genotoxicity has been carried out with six of the 32 flavouring agents in this group (Nos 1209, 1219, 1220, 1223, 1225, and 123
WHO/JECFA NOEL =125 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=ea19e09729190fcd; raw_unit=mg/kg bw per day; context=On this basis, the NOEL for citral was 125 mg/kg bw per day for maternal toxicity and 250 mg/kg bw per day for developmental toxicity (Vollmuth et al., 1990).
WHO/JECFA NOEL =142.857142857143 mg/kg bw/day Rat oral 5 days Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=b2736008122eadb9; raw_unit=mg/kg bw per day; unit_normalization=converted from weekly dose; context=In groups of 50 male and 50 female Fischer 344/N rats given this mixture at a dose of 0, 1000 or 2000 mg/kg bw per day, 5 days per week for 103 weeks by gavage, the NOEL for the mixture was 1000 mg/kg bw per day, corresponding to an estimated dose of 710 mg/kg bw per day of geranyl acetate and 290 mg/kg bw per day of citronellyl acetate. (i) Citral (No.
WHO/JECFA NOEL <345 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6e68b40be4c28ee2; raw_unit=mg/kg bw per day; context=The NOEL for citral was <345 mg/kg bw per day in male rats, on the basis of nephropathy.
WHO/JECFA NOEL =500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=39378074f773814b; raw_unit=mg/kg bw per day; context=The NOEL for citral was 500 mg/kg bw per day, the highest dose tested (Hagan et al., 1967).
WHO/JECFA NOEL <534 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=461043bc731e7211; raw_unit=mg/kg bw per day; context=The NOEL was <534 mg/kg bw per day on the basis of increased liver weights.
WHO/JECFA NOEL =570 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=f413a3a2971ee2a0; raw_unit=mg/kg bw per day; context=The NOEL for citral was 570 mg/kg bw per day on the basis of nasal lesions and decreased body weights (Dieter et al., 1993).
WHO/JECFA NOEL =675 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=71fb18eb47f5afe9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL was 675 mg/kg bw per day, on the basis of decreased body weights and body-weight gains, and bone marrow atrophy (National Toxicology Program, 2003). (ii) 2,4-Dimethyl-2-pentenoic acid (No.
WHO/JECFA NOEL <745 mg/kg bw/day Mouse - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=53988f6f6e951628; raw_unit=mg/kg bw per day; context=The NOEL for citral was <745 mg/kg bw per day in male mice on the basis of decreased body weights and body-weight gains, and reductions in lymphocyte and leukocyte counts.
WHO/JECFA NOEL <790 mg/kg bw/day Mouse - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=6c3849630141e03c; raw_unit=mg/kg bw per day; context=In female mice, the NOEL was <790 mg/kg bw per day on the basis of decreased body weights and body-weight gains (National Toxicology Program, 2003).
WHO/JECFA NOEL =1140 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a683b140a1d0a6ac; raw_unit=mg/kg bw per day; context=The NOEL for citral was 1140 mg/kg bw per day in male rats on the basis of forestom-ach lesions.
WHO/JECFA NOEL =2280 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=a5dc314ddc5afdb9; raw_unit=mg/kg bw per day; context=In female rats, the NOEL for citral was 2280 mg/kg bw per day, the highest dose tested.
WHO/JECFA NOEL =4275 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v52je15; title=ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je15.htm; row_hash=2f7815776afef952; raw_unit=mg/kg bw per day; context=The NOEL for citral was 4275 mg/kg bw per day, on the basis of decreased body weights (Dieter et al., 1993).
WHO/JECFA NOEL =2.06 mg/kg bw/day Rat - 28-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f38134d6d683c7cd; raw_unit=mg/kg bw per day; context=1284 ( E )-3,( Z )-6-Nonadien-1-ol 92% 6% ( E,E ) isomer In a 28-day study in rats, a NOEL* of 2.06 mg/kg bw per day was reported for the structurally related material ( E,Z )-2,6-dodecadienal (No.
WHO/JECFA NOEL =10 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=7aa3e892bfacc240; raw_unit=mg/kg bw per day; context=A NOEL of 10 mg/kg bw per day was reported for the structurally related substance, beta- ionone (No.
WHO/JECFA NOEL =30 mg/kg bw/day Rat oral 13-week Subchronic toxicity document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=13cce56a91464508; raw_unit=mg/kg bw per day; context=A 13-week study of oral administration in rats identified a NOEL of 30 mg/kg bw per day for this material (Gaunt, 1971).
WHO/JECFA NOEL =32 mg/kg bw/day Mouse - 80-week Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=9a42cdc9dd4795ad; raw_unit=mg/kg bw per day; context=In an 80-week study in mice a NOEL of 32 mg/kg bw per day was reported (Roe et al., 1979).
WHO/JECFA NOEL >50 mg/kg bw/day Rat - 84-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=f82c7ce96269f31c; raw_unit=mg/kg bw per day; context=In an 84-day study in rats, the NOEL for linalool was >50 mg/kg bw per day (Oser, 1967).
WHO/JECFA NOEL =60 mg/kg bw Rat - 98-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=749ac57fbe6bd49a; raw_unit=mg/kg bw; context=A 98-day study with the structurally related material 2,4-hexadienal showed a NOEL of 15 and 60 mg/kg bw for male and female rats, respectively (National Toxicology Program, 2001b).
WHO/JECFA NOEL =100 mg/kg bw/day - - 90-day Subchronic toxicity document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=2c502db7cb4d2e65; raw_unit=mg/kg bw per day; context=A 90-day study for the structurally related material (E,E)-2,4-decadienal identified a NOEL of 100 mg/kg bw per day (National Toxicology Program, 1997).
WHO/JECFA NOEL range:120-150150 mg/kg bw/day - oral 98-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=b3dcd4e63287f3b5; raw_unit=mg/kg bw per day; context=A NOEL of 120-150 mg/kg bw per day was reported for cis -3-hexen-1-ol in a 98-day study of oral administration (Gaunt et al., 1969).
WHO/JECFA NOEL =250 mg/kg bw/day Rat oral 14-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=0b22922f8269a615; raw_unit=mg/kg bw per day; context=In a 14-day study of oral toxicity in rats, isopulegol was reported to have a NOEL of 250 mg/kg bw per day (Imaizumi et al., 1985).
WHO/JECFA NOEL =350 mg/kg bw/day Rat - 63-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=6992895be58d3f53; raw_unit=mg/kg bw per day; context=In a 63-day study in rats, the NOEL for acetic acid was 350 mg/kg bw per day (Pardoe, 1952).
WHO/JECFA NOEL >400 mg/kg bw/day Rat - 2-year Chronic toxicity document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=74fe4d87763b5af8; raw_unit=mg/kg bw per day; context=A NOEL of >400 mg/kg bw per day for formic acid was identified in a 2-year study in rats (Malorny, 1969).
WHO/JECFA NOEL =1200 mg/kg bw/day Rat - 28-day Toxicology study document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=3a43923bf1e999db; raw_unit=mg/kg bw per day; context=In a 28-day study in rats, the NOEL for 1,8-cineole was 300 and 1200 mg/kg bw per day for males and females, respectively (National Toxicology Program, 1987a).
WHO/JECFA NOEL =2000 mg/kg bw/day Rat - 2 years Chronic toxicity document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=369130f62ca03842; raw_unit=mg/kg bw per day; context=A NOEL of 2000 mg/kg bw per day was reported when rats were fed a mixture of 71% geranyl acetate and 29% citronellyl acetate for 2 years (National Toxicology Program, 1987b).
WHO/JECFA NOEL >2500 mg/kg bw/day Rat oral 90-day Subchronic toxicity document_id=jecfa_jecmono_v52je28; title=ANNEX 6 (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je28.htm; row_hash=011f2107208f490a; raw_unit=mg/kg bw per day; context=A 90-day study of oral administration in rats identified a NOEL of >2500 mg/kg bw per day for the structurally related material, isovaleric acid (No.
WHO/JECFA ADI <=0.5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af4bee4b0d99f5a872920; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3485; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=WHO JECFA ADI:15715255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af88f8ad7f485fbcb6f2ef8e9fa34054
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =4895 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity Pesticide Active Ingredients Database (undated); record_id=acute_oral_7349; row=10349; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4950 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7351; row=10347; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4960 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7355; row=10350; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =6800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7357; row=10348; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyl-2,6-octadienal; preferred_name=3,7-Dimethyl-2,6-octadienal; dtxsid=DTXSID6024836; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024836; source_file=acute_oral.xlsx
NTP ICE cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer POLY-3 lowest dose 1000 ppm Mouse Dosed feed - In Vivo; Two year cancer bioassay sheet=Data; excel_row=7004; Record_ID=cancer_2063; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=1000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Hematopoietic system; Lesion=Malignant lymphoma: histiocytic, lymphocytic, mixed, nos, or undifferentiated cell type; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE cancer Top dose 2000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7000; Record_ID=cancer_2060; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE cancer Top dose 4000 ppm Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7007; Record_ID=cancer_2065; Data_Type=In Vivo; Formulation_Name=Citral; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-505; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr505/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3028; RecordID=ARPathway2016_1297; DatasetName=ARPathway2016; DTXSID=DTXSID6024836; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization 156 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 13 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2503; Record_ID=skin_sensitization_invitro_593; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=13; Reported_Response_Unit=ug/mL; Response=13; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CD54, EC200 15 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2186; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=15; Reported_Response_Unit=ug/mL; Response=15; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CD86, EC150 2.2 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8239; Record_ID=skin_sensitization_invitro_2262; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=14.45181633; Reported_Response_Unit=uM; Conversion_Factor_Value=152.237; Conversion_Factor_Source=EPA Dashboard; Converted_Response=2.2; Converted_Response_Unit=ug/mL; Response=2.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CD86, EC150 3.7 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8586; Record_ID=skin_sensitization_invitro_2371; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=3.7; Reported_Response_Unit=ug/mL; Response=3.7; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CD86, EC150 8.41 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2184; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=8.41; Reported_Response_Unit=ug/mL; Response=8.41; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CV70 12.97 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8585; Record_ID=skin_sensitization_invitro_2371; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=U-SENS; Endpoint=CV70; Reported_Response=12.97; Reported_Response_Unit=ug/mL; Response=12.97; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CV75 16.6 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2508; Record_ID=skin_sensitization_invitro_593; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CV75; Reported_Response=16.600000000000001; Reported_Response_Unit=ug/mL; Response=16.6; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization CV75 24 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2188; Record_ID=skin_sensitization_invitro_521; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=h-CLAT; Endpoint=CV75; Reported_Response=24; Reported_Response_Unit=ug/mL; Response=24; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.04167 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7857; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.04167; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.125 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7841; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.3125 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7872; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.4 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7960; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses range0.42 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7909; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=0.42 - 0.84; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.7656 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7886; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.7656; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.025 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7923; Record_ID=skin_sensitization_invivo_1787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.025; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.2 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7881; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.2; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 2.1 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7906; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 3.733 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7893; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.733; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.03333 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7853; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.03333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.1 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7837; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response range0.2 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7905; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response_Modifier=range; Response=0.2 - 0.4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7869; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.3125 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7885; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7904; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 0.8 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7956; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7879; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Concentration, one positive response 1.333 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7891; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=1.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Cys 13.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=384; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=13.9; Reported_Response_Unit=%; Response=13.9; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Cys 78.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=374; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=78.599999999999994; Reported_Response_Unit=%; Response=78.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Cys 85.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=380; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=85.7; Reported_Response_Unit=%; Response=85.7; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys 8.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=373; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=8.6; Reported_Response_Unit=%; Response=8.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys 16.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=379; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=16.899999999999999; Reported_Response_Unit=%; Response=16.9; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys 19.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=383; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=19.600000000000001; Reported_Response_Unit=%; Response=19.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys + Cys 14 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=385; Record_ID=skin_sensitization_invitro_119; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=14; Reported_Response_Unit=%; Response=14; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys + Cys 43.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=376; Record_ID=skin_sensitization_invitro_117; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=43.6; Reported_Response_Unit=%; Response=43.6; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Depletion Lys + Cys 51.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=381; Record_ID=skin_sensitization_invitro_118; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=51.3; Reported_Response_Unit=%; Response=51.3; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 6.75 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5931; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.75; Reported_Response_Unit=uM; Response=6.75; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 7.66 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5932; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.66; Reported_Response_Unit=uM; Response=7.66; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 12.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5908; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=12.6; Reported_Response_Unit=uM; Response=12.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 13.46 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5909; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.46; Reported_Response_Unit=uM; Response=13.46; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 14.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5910; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.8; Reported_Response_Unit=uM; Response=14.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 15.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5911; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.3; Reported_Response_Unit=uM; Response=15.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 16.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5912; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.100000000000001; Reported_Response_Unit=uM; Response=16.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 16.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5913; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.3; Reported_Response_Unit=uM; Response=16.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 16.37 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5914; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.37; Reported_Response_Unit=uM; Response=16.37; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 16.91 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5915; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.91; Reported_Response_Unit=uM; Response=16.91; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 17 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5916; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17; Reported_Response_Unit=uM; Response=17; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 17.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5917; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.2; Reported_Response_Unit=uM; Response=17.2; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 17.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5918; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.3; Reported_Response_Unit=uM; Response=17.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 17.33 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5919; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.329999999999998; Reported_Response_Unit=uM; Response=17.33; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 18.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5920; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.3; Reported_Response_Unit=uM; Response=18.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 18.46 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5921; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.46; Reported_Response_Unit=uM; Response=18.46; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 19.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5922; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=19.2; Reported_Response_Unit=uM; Response=19.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 20.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5923; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=20.399999999999999; Reported_Response_Unit=uM; Response=20.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 21.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5924; Record_ID=skin_sensitization_invitro_1389; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=21.2; Reported_Response_Unit=uM; Response=21.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 22.66 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5925; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=22.66; Reported_Response_Unit=uM; Response=22.66; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 23.16 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5926; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.164999999999999; Reported_Response_Unit=uM; Response=23.16; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 23.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5927; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.2; Reported_Response_Unit=uM; Response=23.2; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 23.88 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5928; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.88; Reported_Response_Unit=uM; Response=23.88; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 25.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5929; Record_ID=skin_sensitization_invitro_1390; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=25.1; Reported_Response_Unit=uM; Response=25.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 34.37 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5930; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=34.369999999999997; Reported_Response_Unit=uM; Response=34.37; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC1.5 <48.23 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7595; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=48.23; Reported_Response_Unit=uM; Response=48.23; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 4.6 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12938; Record_ID=skin_sensitization_invivo_2867; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=4.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 5.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13138; Record_ID=skin_sensitization_invivo_3155; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ashby et al. 1995; 8553361; 10.1016/0300-483x(95)03132-y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 5.3 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12940; Record_ID=skin_sensitization_invivo_2867; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 5.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13135; Record_ID=skin_sensitization_invivo_3151; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=5.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 6.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13072; Record_ID=skin_sensitization_invivo_3057; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 6.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13130; Record_ID=skin_sensitization_invivo_3144; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=6.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 9.2 % Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12877; Record_ID=skin_sensitization_invivo_493; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=9.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 12 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13132; Record_ID=skin_sensitization_invivo_3146; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=12; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 12.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13136; Record_ID=skin_sensitization_invivo_3153; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=12.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 13 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13127; Record_ID=skin_sensitization_invivo_3141; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=EC3; Response=13; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization EC3 67.36 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5933; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=67.361999999999995; Reported_Response_Unit=uM; Response=67.36; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 100.29 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5934; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=100.29; Reported_Response_Unit=uM; Response=100.29; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 102.77 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5935; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=102.77; Reported_Response_Unit=uM; Response=102.77; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 103.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5936; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=103.5; Reported_Response_Unit=uM; Response=103.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 107.67 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5937; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=107.67; Reported_Response_Unit=uM; Response=107.67; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 113.87 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5938; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=113.87; Reported_Response_Unit=uM; Response=113.87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 >120 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7665; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=120; Reported_Response_Unit=uM; Response=120; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 122.19 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5939; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=122.19; Reported_Response_Unit=uM; Response=122.19; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 156.01 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5940; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=156.01; Reported_Response_Unit=uM; Response=156.01; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 159.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5941; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=159.30000000000001; Reported_Response_Unit=uM; Response=159.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 166.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5942; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=166.9; Reported_Response_Unit=uM; Response=166.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 167.99 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5943; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=167.99; Reported_Response_Unit=uM; Response=167.99; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 170.91 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5944; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=170.91; Reported_Response_Unit=uM; Response=170.91; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 171.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5945; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=171.8; Reported_Response_Unit=uM; Response=171.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 177.25 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5946; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=177.25; Reported_Response_Unit=uM; Response=177.25; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 182.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5947; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=182.8; Reported_Response_Unit=uM; Response=182.8; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 182.81 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5948; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=182.81; Reported_Response_Unit=uM; Response=182.81; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 193.55 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5949; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=193.55; Reported_Response_Unit=uM; Response=193.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 207.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5950; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=207.4; Reported_Response_Unit=uM; Response=207.4; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 209.89 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5951; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=209.89; Reported_Response_Unit=uM; Response=209.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 212.06 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5952; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=212.06; Reported_Response_Unit=uM; Response=212.06; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 226.64 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5953; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=226.64; Reported_Response_Unit=uM; Response=226.64; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 238.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5954; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=238.8; Reported_Response_Unit=uM; Response=238.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 241 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5955; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=241; Reported_Response_Unit=uM; Response=241; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization IC50 249.47 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5956; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=249.47; Reported_Response_Unit=uM; Response=249.47; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 9.534 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5990; Record_ID=skin_sensitization_invitro_1394; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.5340000000000007; Reported_Response_Unit=Unitless; Response=9.534; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 10.426 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5957; Record_ID=skin_sensitization_invitro_1399; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=10.426; Reported_Response_Unit=Unitless; Response=10.426; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 16.381 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5963; Record_ID=skin_sensitization_invitro_1395; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.381; Reported_Response_Unit=Unitless; Response=16.381; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 22.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5965; Record_ID=skin_sensitization_invitro_1407; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.3; Reported_Response_Unit=Unitless; Response=22.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 23.72 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5967; Record_ID=skin_sensitization_invitro_1398; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.716000000000001; Reported_Response_Unit=Unitless; Response=23.72; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 32.32 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7568; Record_ID=skin_sensitization_invitro_1834; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LuSens; Endpoint=Imax; Reported_Response=32.32188705; Reported_Response_Unit=Unitless; Response=32.32; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 35.86 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5969; Record_ID=skin_sensitization_invitro_1392; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=35.86; Reported_Response_Unit=Unitless; Response=35.86; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 38.59 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5971; Record_ID=skin_sensitization_invitro_1405; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=38.591000000000001; Reported_Response_Unit=Unitless; Response=38.59; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 40 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5973; Record_ID=skin_sensitization_invitro_1408; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=40; Reported_Response_Unit=Unitless; Response=40; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 41.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5975; Record_ID=skin_sensitization_invitro_1396; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=41.103000000000002; Reported_Response_Unit=Unitless; Response=41.1; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 50.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5977; Record_ID=skin_sensitization_invitro_1410; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=50.2; Reported_Response_Unit=Unitless; Response=50.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 50.84 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5979; Record_ID=skin_sensitization_invitro_1391; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=50.835000000000001; Reported_Response_Unit=Unitless; Response=50.84; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 51.59 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5981; Record_ID=skin_sensitization_invitro_1404; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=51.591999999999999; Reported_Response_Unit=Unitless; Response=51.59; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 59.91 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5983; Record_ID=skin_sensitization_invitro_1403; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=59.911000000000001; Reported_Response_Unit=Unitless; Response=59.91; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 60.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5985; Record_ID=skin_sensitization_invitro_1406; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=60.2; Reported_Response_Unit=Unitless; Response=60.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 76.96 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5987; Record_ID=skin_sensitization_invitro_1402; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=76.959999999999994; Reported_Response_Unit=Unitless; Response=76.96; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 84.55 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5988; Record_ID=skin_sensitization_invitro_1390; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=84.55; Reported_Response_Unit=Unitless; Response=84.55; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 85.78 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5989; Record_ID=skin_sensitization_invitro_1397; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=85.775999999999996; Reported_Response_Unit=Unitless; Response=85.78; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 93.89 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5991; Record_ID=skin_sensitization_invitro_1393; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=93.894000000000005; Reported_Response_Unit=Unitless; Response=93.89; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 96.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5993; Record_ID=skin_sensitization_invitro_1388; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=96.4; Reported_Response_Unit=Unitless; Response=96.4; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2011; 22023385; 10.1021/tx2003678|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 96.42 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5995; Record_ID=skin_sensitization_invitro_1386; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=96.42; Reported_Response_Unit=Unitless; Response=96.42; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 103.571 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5958; Record_ID=skin_sensitization_invitro_1401; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=103.571; Reported_Response_Unit=Unitless; Response=103.571; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 104.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5959; Record_ID=skin_sensitization_invitro_1409; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=104.4; Reported_Response_Unit=Unitless; Response=104.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 107.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5960; Record_ID=skin_sensitization_invitro_1387; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=107.3; Reported_Response_Unit=Unitless; Response=107.3; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 108.277 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5961; Record_ID=skin_sensitization_invitro_1389; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=108.277; Reported_Response_Unit=Unitless; Response=108.277; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Imax 132.8 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5962; Record_ID=skin_sensitization_invitro_1400; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=132.81800000000001; Reported_Response_Unit=Unitless; Response=132.8; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7894; Record_ID=skin_sensitization_invivo_1782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 2.381 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7900; Record_ID=skin_sensitization_invivo_1784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.381; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 4 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7833; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7865; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 8.333 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7877; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 9.756 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7918; Record_ID=skin_sensitization_invivo_1787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=9.756; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 10.71 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7889; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=10.71; Response_Unit=%; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 12 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7849; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=12; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 32.65 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7966; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=32.65; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 47.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7901; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=47.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Incidence of positive responses 50 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7952; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=50; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area 64.8 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7831; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=64.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area 324 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7863; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=324; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area 775 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7910; Record_ID=skin_sensitization_invivo_1785; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7876; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area range3100 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7899; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response_Modifier=range; Response=3100 - 6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area 6200 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7888; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 27 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7859; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=27; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 81 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7843; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=81; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 202.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7874; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=202.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 310 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7962; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=310; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses range326 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7911; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=326 - 652; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 777.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7882; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=777.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 2893 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7895; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2893; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response 21.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7855; Record_ID=skin_sensitization_invivo_1775; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=21.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response 162 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7871; Record_ID=skin_sensitization_invivo_1778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=162; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response range163 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7907; Record_ID=skin_sensitization_invivo_1783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response_Modifier=range; Response=163 - 326; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response 620 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7958; Record_ID=skin_sensitization_invivo_1790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=620; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response 648 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7880; Record_ID=skin_sensitization_invivo_1779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Induction dose per skin area, one positive response 1033 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7892; Record_ID=skin_sensitization_invivo_1781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=1033; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Maibach 1971: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Max stimulation index 20.5 ratio Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12876; Record_ID=skin_sensitization_invivo_493; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=LLNA; Endpoint=Max stimulation index; Response=20.5; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7845; Record_ID=skin_sensitization_invivo_1772; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90288-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
NTP ICE skin sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7887; Record_ID=skin_sensitization_invivo_1780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024836; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461522; 10.1016/0015-6264(80)90199-6|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024836; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024836
SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =3 µg/cm2 human - - sensitisation p.60
SCCS Opinion NOAEL =61 - human - - sensitisation p.61
SCCS Opinion NOAEL =500 - - - - NOAEL study p.61
SCCS Opinion NOAEL =1400 µg/cm2 human - - sensitisation p.18
SCCS Opinion NOAEL =1417 μg/cm2 human - - sensitisation p.18
SCCS Opinion NOAEL =1666 - guinea pig - - sensitisation p.61
SCCS Opinion NOAEL >2500 - - - - NOAEL study p.61
SCCS Opinion NOAEL =3448 μg/cm2 human dermal - sensitisation p.19
SCCS Opinion NOAEL >10000 - - - - NOAEL study p.61
EPA ToxRefDB v3 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA ToxRefDB v3 LEL =60 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=5254; toxval_study_source_id=studyid5254_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-mineralization|in life observation-body weight-body weight|pathology microscopic-bone-fibrosis|pathology gross-full gross necropsy-lymphoma malignant|pathology microscopic-kidney-nephropathy; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =120 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=5254; toxval_study_source_id=studyid5254_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-adrenal gland-hyperplasia; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =210 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 2 year CHR study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-adrenal gland-angiectasis|in life observation-body weight-body weight; dose_level=3; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =335 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-bone marrow-atrophy|in life observation-food consumption-food consumption|in life observation-clinical signs-[other]|pathology microscopic-bone marrow-hemorrhage|in life observation-clinical signs-impaired reflex, nos|in life observation-clinical signs-hunched posture|in life observation-mortality-mortality|pathology microscopic-stomach-hyperkeratosis|in life observation-clinical signs-lethargy|pathology microscopic-stomach-hyperplasia|pathology microscopic-thymus-atrophy; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =345 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-kidney-nephropathy|pathology microscopic-stomach-hyperkeratosis|in life observation-clinical signs-[other]|pathology microscopic-bone marrow-atrophy|in life observation-mortality-mortality|in life observation-clinical signs-lethargy|in life observation-clinical signs-hunched posture|in life observation-clinical signs-impaired reflex, nos|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption|pathology microscopic-thymus-atrophy|pathology microscopic-testes-aspermia|pathology microscopic-bone marrow-hemorrhage; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =745 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=5251; toxval_study_source_id=studyid5251_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|hematology-lymphocyte-lymphocyte|in life observation-mortality-mortality; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =790 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=5251; toxval_study_source_id=studyid5251_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|pathology microscopic-ovary-atrophy|hematology-lymphocyte-lymphocyte; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Mouse Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =675 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =820 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=5248; toxval_study_source_id=studyid5248_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|in life observation-mortality-mortality|pathology microscopic-bone marrow-atrophy|in life observation-clinical signs-hunched posture|in life observation-clinical signs-impaired reflex, nos|pathology microscopic-bone marrow-hemorrhage|in life observation-clinical signs-[other]|in life observation-body weight-body weight gain|pathology microscopic-thymus-atrophy|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption|in life observation-clinical signs-lethargy|in life observation-body weight-body weight; dose_level=0; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Subchronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =50 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 2 year CHR study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-mineralization|in life observation-body weight-body weight; dose_level=1; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =100 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 2 year CHR study_id=5252; toxval_study_source_id=studyid5252_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-adrenal gland-angiectasis; dose_level=2; study_year=2003; study_citation=(2003) 'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).' (Rat Chronic portion); dsstox_substance_id=DTXSID6024836; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =20 % Mouse dermal short-term; 16 days short-term LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608174:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=651e9a260ec697c4c205fe85483059d4
ToxValDB EPA TSCA 8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA TSCA 8e NEL =200 mg/kg bw/day Rabbit oral short-term (developmental); 23 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20502_2155_C.pdf; TOXICOLOGICAL_EFFECT=F1: no evidence of selective developmental toxicity; STUDY_GROUP=EPA TSCA 8e:15956451:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e6e1be54fc0f04d5fb79e1aa745034d
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630737:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d86a625c047a2fd5602673ea1a8ae3e3
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL <335 mg/kg bw/day Rat oral chronic; 14 weeks chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df3e4b0a676289de9dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Blood Chemistry: BUN increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=HESS:15638949:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea956633d7bbb69c53c9112d1bef222d
ToxValDB ToxRefDB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ToxRefDB LEL =60 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5254; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-bone-fibrosis|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-mineralization|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology gross-full gross necropsy-lymphoma malignant; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708827_15708828:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f70ed96a04e19e0e4cacc173a05ccb63
ToxValDB ToxRefDB LEL =120 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5254; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-adrenal gland-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708829_15708830:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c69543d52f6f2b0e7f38ed5fba7de30
ToxValDB ToxRefDB LEL =210 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708821_15708822_15708823_15708824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9a0b1b779c37faf514f983b1b738ef9
ToxValDB ToxRefDB LEL =745 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5251; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: hematology-lymphocyte-lymphocyte|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15708819_15708820:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1c0aa46b7225a4120541b5e160e9ca7
ToxValDB ToxRefDB LEL =790 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Mouse Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5251; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: hematology-lymphocyte-lymphocyte|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: pathology microscopic-ovary-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708817_15708818:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d3e8fbc74d61f74d0f5abe75ffa4870
ToxValDB ToxRefDB LOAEL =675 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5248; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708811_15708812_15708813:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_064d8db124cb322170df4b54f7acb260
ToxValDB ToxRefDB LOAEL =820 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Subchronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5248; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708814_15708815_15708816:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8746bd639e3fab44baa7f28bef81afcc
ToxValDB ToxRefDB NEL =50 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-mineralization|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708825_15708826:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58821f43841f14a0ae3f8bc59977fe3e
ToxValDB ToxRefDB NEL =100 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=(2003) \'NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES).\' (Rat Chronic portion); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5252; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708821_15708822_15708823_15708824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc08b79a3ec8ff00a273558708ec8fef
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 500 - - - - - p.61
Regulatory source - >2500 - - - - - p.61
Regulatory source - >10000 - - - - - p.61
Regulatory source sensitisation 3 µg/cm2 human - - sensitisation p.60
Regulatory source sensitisation 61 - human - - sensitisation p.61
Regulatory source sensitisation 1400 µg/cm2 human - - sensitisation p.18
Regulatory source sensitisation 1417 μg/cm2 human - - sensitisation p.18
Regulatory source sensitisation 1417 μg/cm2 - - - sensitisation p.34
Regulatory source sensitisation 1666 - guinea pig - - sensitisation p.61
Regulatory source sensitisation 3448 μg/cm2 human dermal - sensitisation p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T7EU0O9VPP UNII - - - mixture -