Good Cosmetic Ingredient NOAEL Data

Citrus Aurantium Dulcis Flower Extract

INCI: CITRUS AURANTIUM DULCIS FLOWER EXTRACT

CAS Number
8028-48-6
Function
Skin conditioning, astringent, toning, masking
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restriction; used as skin conditioning and toning ingredient in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Citrus Aurantium Dulcis Flower Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 mg/kg bw/day oral rat oral REACH
NOAEL 5 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral dog oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL 600 mg/kg bw/day oral rat oral REACH
NOAEL 600 mg/kg bw/day oral - oral REACH
NOAEL 500 mg/kg bw/day oral mouse oral REACH
NOAEL 500 mg/kg bw/day oral - oral REACH
NOAEL 100 mg/kg bw/day oral dog oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH

Expert Verdict

Extract from sweet orange (Citrus aurantium dulcis) flowers. Rich in flavonoids, essential oils, and beneficial phytochemicals. Functions as astringent, tonic, skin conditioner, and masking agent. No EU or US restrictions. Well-tolerated ingredient with good antioxidant and toning properties.

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Concern Level: Low

Regulatory Flags

plant-extract skin-conditioning antioxidant flavonoids toning astringent low-hazard ifra_fragrance

Frequently Asked Questions

Is Citrus Aurantium Dulcis Flower Extract safe in cosmetics?

Extract from sweet orange (Citrus aurantium dulcis) flowers. Rich in flavonoids, essential oils, and beneficial phytochemicals. Functions as astringent, tonic, skin conditioner, and masking agent. No EU or US restrictions. Well-tolerated ingredient with good antioxidant and toning properties. The EU classifies Citrus Aurantium Dulcis Flower Extract as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Citrus Aurantium Dulcis Flower Extract allowed in the EU?

Citrus Aurantium Dulcis Flower Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrus Aurantium Dulcis Flower Extract do in cosmetics?

Citrus Aurantium Dulcis Flower Extract functions as: Skin conditioning, astringent, toning, masking. It is classified as a cosmetic ingredient in our database. CAS number: 8028-48-6.

What is the Margin of Safety for Citrus Aurantium Dulcis Flower Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citrus Aurantium Dulcis Flower Extract?

The NOAEL (No Observed Adverse Effect Level) for Citrus Aurantium Dulcis Flower Extract is 5 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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