Moderate Cosmetic Ingredient NOAEL Data

Citrus Aurantium Dulcis Flower

INCI: CITRUS AURANTIUM DULCIS FLOWER

CAS Number
8028-48-6
Function
Skin conditioning — miscellaneous
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: Data insufficient to determine safety (2016 tentative report on 33 citrus flower/leaf ingredients). Sweet orange flowers are GRAS as food (21 CFR 182.20)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Citrus Aurantium Dulcis Flower. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 mg/kg bw/day oral rat oral REACH
NOAEL 5 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral dog oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL 600 mg/kg bw/day oral rat oral REACH
NOAEL 600 mg/kg bw/day oral - oral REACH
NOAEL 500 mg/kg bw/day oral mouse oral REACH
NOAEL 500 mg/kg bw/day oral - oral REACH
NOAEL 100 mg/kg bw/day oral dog oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH

Expert Verdict

CIR concluded insufficient data for safety determination; no genotoxicity or repeat-dose toxicity data available, and pesticide residue and heavy metal monitoring required.

⚠️
Concern Level: Moderate

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is Citrus Aurantium Dulcis Flower safe in cosmetics?

CIR concluded insufficient data for safety determination; no genotoxicity or repeat-dose toxicity data available, and pesticide residue and heavy metal monitoring required. The EU classifies Citrus Aurantium Dulcis Flower as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Citrus Aurantium Dulcis Flower allowed in the EU?

Citrus Aurantium Dulcis Flower EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrus Aurantium Dulcis Flower do in cosmetics?

Citrus Aurantium Dulcis Flower functions as: Skin conditioning — miscellaneous. It is classified as a cosmetic ingredient in our database. CAS number: 8028-48-6.

What is the Margin of Safety for Citrus Aurantium Dulcis Flower?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citrus Aurantium Dulcis Flower?

The NOAEL (No Observed Adverse Effect Level) for Citrus Aurantium Dulcis Flower is 5 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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