Moderate Cosmetic Ingredient NOAEL Data

Citrus Aurantium Dulcis Flower/Leaf/Stem Powder

INCI: CITRUS AURANTIUM DULCIS FLOWER/LEAF/STEM POWDER

CAS Number
8028-48-6
Function
Skin conditioning; exfoliant (botanical powder)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not individually CIR-reviewed. Whole-plant powders lack dedicated monograph. GRAS food status covers sweet orange plant parts broadly (21 CFR 182.20)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Citrus Aurantium Dulcis Flower/Leaf/Stem Powder. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 mg/kg bw/day oral rat oral REACH
NOAEL 5 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral dog oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL 600 mg/kg bw/day oral rat oral REACH
NOAEL 600 mg/kg bw/day oral - oral REACH
NOAEL 500 mg/kg bw/day oral mouse oral REACH
NOAEL 500 mg/kg bw/day oral - oral REACH
NOAEL 100 mg/kg bw/day oral dog oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH

Expert Verdict

Multi-plant-part ingredient increases compositional variability. Pesticide residues, heavy metals, and microbial load must be tested. No dedicated safety assessment exists.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

natural-origin ifra_fragrance

Frequently Asked Questions

Is Citrus Aurantium Dulcis Flower/Leaf/Stem Powder safe in cosmetics?

Multi-plant-part ingredient increases compositional variability. Pesticide residues, heavy metals, and microbial load must be tested. No dedicated safety assessment exists. The EU classifies Citrus Aurantium Dulcis Flower/Leaf/Stem Powder as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Citrus Aurantium Dulcis Flower/Leaf/Stem Powder allowed in the EU?

Citrus Aurantium Dulcis Flower/Leaf/Stem Powder EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrus Aurantium Dulcis Flower/Leaf/Stem Powder do in cosmetics?

Citrus Aurantium Dulcis Flower/Leaf/Stem Powder functions as: Skin conditioning; exfoliant (botanical powder). It is classified as a cosmetic ingredient in our database. CAS number: 8028-48-6.

What is the Margin of Safety for Citrus Aurantium Dulcis Flower/Leaf/Stem Powder?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citrus Aurantium Dulcis Flower/Leaf/Stem Powder?

The NOAEL (No Observed Adverse Effect Level) for Citrus Aurantium Dulcis Flower/Leaf/Stem Powder is 5 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is Citrus Aurantium Dulcis Flower/Leaf/Stem Powder in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Citrus Aurantium Dulcis Flower/Leaf/Stem Powder in your formulation.