Clinopodium Nepeta Extract (Lesser Calamint Extract)

INCI: CLINOPODIUM NEPETA EXTRACT

CAS Number
223748-11-6
Function
Skin conditioning; Tonic; Antimicrobial; Anti-inflammatory. Extract obtained from the aerial parts (flowers, leaves, stems) of Clinopodium nepeta (L.) Kuntze (syn. Calamintha nepeta), a perennial aromatic herb of the Lamiaceae family native to the Mediterranean region. Contains rosmarinic acid, luteolin, ursolic acid, pulegone, and other polyphenols with documented antioxidant, antimicrobial, and anti-inflammatory properties. A 2025 dermatoprotective study confirmed anti-elastase, anti-tyrosinase, and photoprotective activities. Essential oil from the plant contains pulegone as a major constituent. Functions in cosmetics as a skin conditioning and tonic agent.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted by FDA for cosmetic use. The essential oil of this plant contains pulegone, a compound subject to IFRA restrictions; however, at the extract level used in cosmetics, pulegone levels are expected to be low. Standard cosmetic safety substantiation per 21 CFR required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Well-tolerated botanical extract with solid phytochemical rationale for antioxidant, anti-inflammatory, and skin conditioning applications. Pulegone present in essential oil is not a concern at extract concentrations used topically. Good overall safety profile.

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Concern Level: Low

Regulatory Flags

plant-extract skin-conditioning antioxidant anti-inflammatory antimicrobial tonic lamiaceae rosmarinic-acid pulegone-monitor mediterranean-botanical

Frequently Asked Questions

Is Clinopodium Nepeta Extract (Lesser Calamint Extract) safe in cosmetics?

Well-tolerated botanical extract with solid phytochemical rationale for antioxidant, anti-inflammatory, and skin conditioning applications. Pulegone present in essential oil is not a concern at extract concentrations used topically. Good overall safety profile. The EU classifies Clinopodium Nepeta Extract (Lesser Calamint Extract) as "permitted". Safety rating: GOOD.

Is Clinopodium Nepeta Extract (Lesser Calamint Extract) allowed in the EU?

Clinopodium Nepeta Extract (Lesser Calamint Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Clinopodium Nepeta Extract (Lesser Calamint Extract) do in cosmetics?

Clinopodium Nepeta Extract (Lesser Calamint Extract) functions as: Skin conditioning; Tonic; Antimicrobial; Anti-inflammatory. Extract obtained from the aerial parts (flowers, leaves, stems) of Clinopodium nepeta (L.) Kuntze (syn. Calamintha nepeta), a perennial aromatic herb of the Lamiaceae family native to the Mediterranean region. Contains rosmarinic acid, luteolin, ursolic acid, pulegone, and other polyphenols with documented antioxidant, antimicrobial, and anti-inflammatory properties. A 2025 dermatoprotective study confirmed anti-elastase, anti-tyrosinase, and photoprotective activities. Essential oil from the plant contains pulegone as a major constituent. Functions in cosmetics as a skin conditioning and tonic agent.. It is classified as a cosmetic ingredient in our database. CAS number: 223748-11-6.

What is the Margin of Safety for Clinopodium Nepeta Extract (Lesser Calamint Extract)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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