Asarum Sieboldii Rhizome/Root Extract

INCI: ASARUM SIEBOLDII RHIZOME/ROOT EXTRACT

CAS Number
223748-00-3
Function
Skin Conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted by FDA for cosmetic use; however, FDA has issued warnings (2000โ€“2001) urging manufacturers to ensure botanical products are free of aristolochic acids

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Critical โ€” Asarum species may contain aristolochic acids, which are classified as known human carcinogens (Group 1 by IARC) with nephrotoxic effects. Aristolochic acid content varies by species and plant part; rhizome/root preparations require batch testing. FDA banned aristolochic acid-containing botanicals from dietary supplements and urged cosmetic manufacturers to verify absence.

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Asarum Sieboldii Rhizome/Root Extract safe in cosmetics?

Critical โ€” Asarum species may contain aristolochic acids, which are classified as known human carcinogens (Group 1 by IARC) with nephrotoxic effects. Aristolochic acid content varies by species and plant part; rhizome/root preparations require batch testing. FDA banned aristolochic acid-containing botanicals from dietary supplements and urged cosmetic manufacturers to verify absence. The EU classifies Asarum Sieboldii Rhizome/Root Extract as "permitted". Safety rating: POOR.

Is Asarum Sieboldii Rhizome/Root Extract allowed in the EU?

Asarum Sieboldii Rhizome/Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Asarum Sieboldii Rhizome/Root Extract do in cosmetics?

Asarum Sieboldii Rhizome/Root Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 223748-00-3.

What is the Margin of Safety for Asarum Sieboldii Rhizome/Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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