Good Cosmetic Ingredient NOAEL Data

Coco-Betaine

INCI: COCO-BETAINE

CAS Number
68424-94-2
Function
Antistatic, hair conditioning, skin conditioning, surfactant (cleansing and foam booster), viscosity increasing
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR 2014 concluded safe in present practices when formulated to be non-irritating. 227 formulations reported in VCRP 2013.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for Coco-Betaine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >100 mg/kg bw/day oral rat oral REACH
NOAEL ca.30 mg/kg bw/day oral rat oral REACH
NOAEL 50 mg/kg bw/day oral rat oral REACH
NOEL 33 mg/kg bw/day oral rat oral REACH
NOEL 250 mg/kg bw/day oral rat oral REACH
NOAEL 350 mg/kg bw/day oral rat oral REACH
NOEL 300 mg/kg bw/day oral rat oral REACH
NOEL 247 mg/kg bw/day oral rat oral REACH
NOAEL 10 mg/kg bw/day oral rat oral REACH

Expert Verdict

True alkyl betaine with lower sensitization risk than CAPB, well-tolerated in rinse-off use at typical concentrations.

⚠️
Concern Level: Low

Regulatory Flags

epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Coco-Betaine safe in cosmetics?

True alkyl betaine with lower sensitization risk than CAPB, well-tolerated in rinse-off use at typical concentrations. The EU classifies Coco-Betaine as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.

Is Coco-Betaine allowed in the EU?

Coco-Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Coco-Betaine do in cosmetics?

Coco-Betaine functions as: Antistatic, hair conditioning, skin conditioning, surfactant (cleansing and foam booster), viscosity increasing. It is classified as a cosmetic ingredient in our database. CAS number: 68424-94-2.

What is the Margin of Safety for Coco-Betaine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Coco-Betaine?

The NOAEL (No Observed Adverse Effect Level) for Coco-Betaine is >100 mg/kg bw/day based on a oral study via oral route in rat. A total of 9 study endpoints are available. Source: REACH.

Compliance Tools

Check Coco-Betaine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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