Good Cosmetic Ingredient NOAEL Data

Lanolin Acid

INCI: LANOLIN ACID

CAS Number
68424-43-1
Function
Skin conditioning – emollient; emulsifying agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR Expert Panel concluded safe in present practices of use and concentration (1980; re-reviewed 2003; reopened and reconfirmed 2024)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Lanolin Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Moderate primary skin irritant when undiluted; seldom used as free acid in cosmetics; pesticide residues possible in lanolin feedstock.

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Concern Level: Low

Frequently Asked Questions

Is Lanolin Acid safe in cosmetics?

Moderate primary skin irritant when undiluted; seldom used as free acid in cosmetics; pesticide residues possible in lanolin feedstock. The EU classifies Lanolin Acid as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Lanolin Acid allowed in the EU?

Lanolin Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lanolin Acid do in cosmetics?

Lanolin Acid functions as: Skin conditioning – emollient; emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 68424-43-1.

What is the Margin of Safety for Lanolin Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lanolin Acid?

The NOAEL (No Observed Adverse Effect Level) for Lanolin Acid is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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