Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Cocotrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOEL | 22 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | ca.113 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | ca.100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Cationic surfactant that is inherently irritating to skin and eyes at high concentrations; must be formulated to be nonirritating. Incompatible with anionic surfactants. Mixture of different chain-length trimoniums (C8–C18 from coconut fatty acids).
Frequently Asked Questions
Is Cocotrimonium Chloride safe in cosmetics?
Cationic surfactant that is inherently irritating to skin and eyes at high concentrations; must be formulated to be nonirritating. Incompatible with anionic surfactants. Mixture of different chain-length trimoniums (C8–C18 from coconut fatty acids). The EU classifies Cocotrimonium Chloride as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Cocotrimonium Chloride allowed in the EU?
Cocotrimonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocotrimonium Chloride do in cosmetics?
Cocotrimonium Chloride functions as: Antistatic Agent; Hair-Conditioning Agent. It is classified as a cosmetic ingredient in our database. CAS number: 61789-18-2.
What is the Margin of Safety for Cocotrimonium Chloride?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cocotrimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Cocotrimonium Chloride is 10 mg/kg bw/day based on a dermal study via dermal route in code:3484. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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