NOAEL Studies
Cosmetic Ingredient
COLOPHONIUM NOAEL Studies
CAS: 8050-09-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =480 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca34e4b0a7c65d220aee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25713?documentUUID=afd67d90-751e-4458-88fc-4e0e98a4e8c5; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847895_15848318_15848623_15848908:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2d333269eedaf29cc1bb0de8af78b5cc |
| ToxValDB_ECHA_IUCLID | NOAEL | =2500 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ecd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25713?documentUUID=afd67d90-751e-4458-88fc-4e0e98a4e8c5; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821994_15822162_15822166_15822420_15822509_15822873_15822922_15823101_15823176:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b5dd884dcaa42bf3f27c0b51ff475b9 |
| ToxValDB_ECHA_IUCLID | NOAEL | =3000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8aee4b0a7c65d219962; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25713?documentUUID=afd67d90-751e-4458-88fc-4e0e98a4e8c5; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15856938:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cefb16f7370786e14621309df6a259c4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =5000 | ppm | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ecd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25713?documentUUID=afd67d90-751e-4458-88fc-4e0e98a4e8c5; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820643_15820821_15820825_15821103_15821189_15821573_15821627_15821821_15821907:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_722f1dd94ea36588e6a9cf33b0eb8901 |
ToxValDB_EPA_TSCA_8e 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =5000 | ppm | Rat | oral | short-term (developmental); 17 days | reproduction developmental | GUIDELINE=OPPTS 870.3700 (OECD 414) - Prenatal Developmental Toxicity Study; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20407_369463.pdf; TOXICOLOGICAL_EFFECT=F1: reduction in fetuses/litters with incomplete ossification of the squamosal bone of the skull, increased fetuses/litters with dumb-bell thoracic centrum, increased fetuses/litters withossification center with 1st lumbar vertebra; STUDY_GROUP=EPA TSCA 8e_dup_-_15957563_15957564_15957565:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_63288c7ee3675a20bb78e70a0c7c85c0 |
| ToxValDB_EPA_TSCA_8e | LEL | =7500 | ppm | Rat | oral | short-term (developmental); 17 days | reproduction developmental | GUIDELINE=OPPTS 870.3700 (OECD 414) - Prenatal Developmental Toxicity Study; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20407_369463.pdf; TOXICOLOGICAL_EFFECT=F1: decreased fetal weights, reduction in fetuses/litters with incomplete ossification of the squamosal bone of the skull, reduction in fetuses/litters with no ossification of the hyoid in the skull, increased fetuses/litters with ossification center with 1st lumbar vertebra; STUDY_GROUP=EPA TSCA 8e_dup_-_15957563_15957564_15957565:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e5a80190db10a1a16fecb641a2d7c6cc |
ToxValDB_HPVIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | NOAEL | ~200 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Calandra, J.C. 1960. Ninety-day subacute oral toxicity of gum rosin. Industrial Bio-Test Laboratories, Inc., Northbrook, Illinois.World Health Organization (WHO). 1990. Principles for the Toxicological Assessment of Pesticide Residues in Food.; QUALITY=1; EXTERNAL_SOURCE_ID=60813; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1960; ORIGINAL_YEAR=1960; STUDY_GROUP=HPVIS:15639661:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d38d6e59f8d5916b8455a360ecc9297d |
| ToxValDB_HPVIS | NOAEL | ~275 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | reproduction developmental | LONG_REF=Clubb, S. and Sutherland, J.R. 2002. Rosin (CAS No. 8050-09-7) Reproduction/Developmental Toxicity Screening Test. Report No. 21491. Inveresk Research, Tranent, Scotland.; TITLE=Rosin (CAS No. 8050-09-7) Reproduction/Developmental Toxicity Screening Test. Report No. 21491; AUTHOR=Clubb, S. and Sutherland, J.R; QUALITY=1; EXTERNAL_SOURCE_ID=58246; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=HPVIS:15642396:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2db5d756485a38cc5f3848024fcc3384 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 88S87KL877 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"88S87KL877"} |
| openFDA substances | FDA UNII substance identifier | 88S87KL877 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"88S87KL877"} |
| openFDA substances | FDA UNII substance identifier | 88S87KL877 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"88S87KL877"} |
| openFDA substances | FDA UNII substance identifier | 88S87KL877 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"88S87KL877"} |