COLOPHONIUM
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for COLOPHONIUM. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.10 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.10 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.10 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 0.2 other | oral | rat | oral | REACH |
| NOAEL | 0.05 other | oral | rat | oral | REACH |
| NOAEL | 4000 ppm | oral | dog | oral | REACH |
| NOAEL | >2200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1 other | oral | dog | oral | REACH |
| NOAEL | 316 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 ppm | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
COLOPHONIUM is listed in the EU CosIng database with functions: Binding, Depilatory, Film Forming, Viscosity Controlling It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is COLOPHONIUM safe in cosmetics?
COLOPHONIUM is listed in the EU CosIng database with functions: Binding, Depilatory, Film Forming, Viscosity Controlling It is permitted in the EU without specific restrictions. The EU classifies COLOPHONIUM as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is COLOPHONIUM allowed in the EU?
COLOPHONIUM EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does COLOPHONIUM do in cosmetics?
COLOPHONIUM functions as: Binding, Depilatory, Film Forming, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 8050-09-7.
What is the NOAEL for COLOPHONIUM?
The NOAEL (No Observed Adverse Effect Level) for COLOPHONIUM is ca.10 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
Check COLOPHONIUM compliance across multiple jurisdictions:
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