Moderate Cosmetic Ingredient NOAEL Data

Commiphora Myrrha Resin Extract

INCI: COMMIPHORA MYRRHA RESIN EXTRACT

CAS Number
84929-26-0
Function
Skin conditioning, nail conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR safety assessment published; no specific FDA cosmetic restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Commiphora Myrrha Resin Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH

Expert Verdict

Sensitization is confirmed but rare; CYP2C8/2C9/2C19 induction at low concentrations relevant for wound applications; no formal margin of safety established.

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Concern Level: Moderate

Regulatory Flags

no-sccs-opinion no-cir-review confirmed-sensitizer-llna human-acd-cases cyp-induction no-mos-calculable eu_children_restricted

Frequently Asked Questions

Is Commiphora Myrrha Resin Extract safe in cosmetics?

Sensitization is confirmed but rare; CYP2C8/2C9/2C19 induction at low concentrations relevant for wound applications; no formal margin of safety established. The EU classifies Commiphora Myrrha Resin Extract as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Commiphora Myrrha Resin Extract allowed in the EU?

Commiphora Myrrha Resin Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Commiphora Myrrha Resin Extract do in cosmetics?

Commiphora Myrrha Resin Extract functions as: Skin conditioning, nail conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84929-26-0.

What is the Margin of Safety for Commiphora Myrrha Resin Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Commiphora Myrrha Resin Extract?

The NOAEL (No Observed Adverse Effect Level) for Commiphora Myrrha Resin Extract is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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