Is Crocetin safe in cosmetics?
Crocetin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Crocetin
Also known as: 2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (all-E)-, 8,8'-Diapo-ψ,ψ-carotenedioic acid, 2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (2E,4E,6E,8E,10E,12E,14E)-, (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic acid, Apocarotenic acid (+8 more)
INCI: CROCETIN
Crocetin (CAS 27876-94-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning (carotenoid pigment from Crocus sativus). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 27876-94-4 →
Function
Antioxidant, skin conditioning (carotenoid pigment from Crocus sativus)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid
InChIKey
PANKHBYNKQNAHN-MQQNZMFNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA: not a listed color additive; permitted as a non-colour cosmetic ingredient; no CIR monograph
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Crocetin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Editorial summary
Preliminary editorial summary for Crocetin — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (all-E)-
8,8'-Diapo-ψ,ψ-carotenedioic acid
2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (2E,4E,6E,8E,10E,12E,14E)-
(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic acid
Apocarotenic acid
Crobit P
Crocetin (stable)
NSC 407300
Stable crocetin
trans-Crocetin
α-Crocetin
transcrocetin
EC No.: 248-708-0
Chemical Function
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRANSCROCETIN
ChEMBL ID
CHEMBL464792
Max Phase
3
Frequently Asked Questions
Is Crocetin allowed in the EU?
Crocetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Crocetin do in cosmetics?
Crocetin functions as: Antioxidant, skin conditioning (carotenoid pigment from Crocus sativus). It is classified as a cosmetic ingredient in our database. CAS number: 27876-94-4.
Is Crocetin used outside cosmetics?
Crocetin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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