Is CROCIN safe in cosmetics?
CROCIN has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
CROCIN
Also known as: BRN 6473367, EINECS 255-881-6, alpha-Crocin, all-trans-Crocetin di-beta-D-gentiobiosyl ester, Crocetin bis(gentiobiosyl) ester
CROCIN (CAS 42553-65-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 42553-65-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Colorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
InChIKey
SEBIKDIMAPSUBY-RTJKDTQDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
antioxidant
{"cas_number": "42553-65-1", "antioxidant_class": "carotenoid", "chemical_subclass": "carotenoid glycoside", "molecular_weight_daltons": "976.97", "orac_value_umol_te_per_g": "1850", "dpph_radical_scavenging_ic50_ug_per_ml": "20-35", "abts_trolox_equivalent": "0.9", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "moderate", "lipid_per…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Dye
Expert Verdict
Expert safety assessment and concern-level summary for CROCIN.
Regulatory Flags
cosing-sourced
eu-permitted
antioxidant
needs-enrichment
Known Synonyms
BRN 6473367
EINECS 255-881-6
alpha-Crocin
all-trans-Crocetin di-beta-D-gentiobiosyl ester
Crocetin bis(gentiobiosyl) ester
Chemical Function
Antioxidant
Dye
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CROCIN
ChEMBL ID
CHEMBL446785
Max Phase
3
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Saffron
E Number
E164
ADI
FOOD INGREDIENT mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is CROCIN allowed in the EU?
CROCIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CROCIN do in cosmetics?
CROCIN functions as: Antioxidant, Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 42553-65-1.
Is CROCIN used outside cosmetics?
CROCIN also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CROCIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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