Good Cosmetic Ingredient NOAEL Data

Curcuma Longa Rhizome Extract

INCI: CURCUMA LONGA RHIZOME EXTRACT

CAS Number
84775-52-0
Function
Antioxidant, cosmetic colorant (CI 75300 cross-reference via curcumin)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA: general cosmetic use permitted; curcumin has GRAS status for food (GRN 686); if used as colorant โ€” color additive considerations apply

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Curcuma Longa Rhizome Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
dose_tested 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Curcuma longa rhizome extract is permitted for use as an antioxidant and cosmetic colorant in both EU and US cosmetics, with established safety profile and adequate margin of safety.

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Concern Level: Low

Regulatory Flags

plant-extract colorant fda_food_additive

Frequently Asked Questions

Is Curcuma Longa Rhizome Extract safe in cosmetics?

Curcuma longa rhizome extract is permitted for use as an antioxidant and cosmetic colorant in both EU and US cosmetics, with established safety profile and adequate margin of safety. The EU classifies Curcuma Longa Rhizome Extract as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Curcuma Longa Rhizome Extract allowed in the EU?

Curcuma Longa Rhizome Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Curcuma Longa Rhizome Extract do in cosmetics?

Curcuma Longa Rhizome Extract functions as: Antioxidant, cosmetic colorant (CI 75300 cross-reference via curcumin). It is classified as a cosmetic ingredient in our database. CAS number: 84775-52-0.

What is the Margin of Safety for Curcuma Longa Rhizome Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Curcuma Longa Rhizome Extract?

The NOAEL (No Observed Adverse Effect Level) for Curcuma Longa Rhizome Extract is 75 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 4 study endpoints are available. Source: COSMOS_DB.

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