Good Cosmetic Ingredient NOAEL Data

Curcuma Longa Root

INCI: CURCUMA LONGA ROOT

CAS Number
84775-52-0
Function
Skin conditioning, abrasive (in powdered forms), cosmetic colorant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA GRAS as food substance; CIR grouped assessment pending (FOU = 220 across Curcuma longa group)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Curcuma Longa Root. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
dose_tested 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Curcumin-driven allergic contact dermatitis risk; photosensitization potential; intense yellow staining; heavy metal contamination possible depending on sourcing (test for Pb, As, Cd, Hg per GMP)

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Concern Level: Moderate

Regulatory Flags

potential-allergen colorant fda_food_additive

Frequently Asked Questions

Is Curcuma Longa Root safe in cosmetics?

Curcumin-driven allergic contact dermatitis risk; photosensitization potential; intense yellow staining; heavy metal contamination possible depending on sourcing (test for Pb, As, Cd, Hg per GMP) The EU classifies Curcuma Longa Root as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Curcuma Longa Root allowed in the EU?

Curcuma Longa Root EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Curcuma Longa Root do in cosmetics?

Curcuma Longa Root functions as: Skin conditioning, abrasive (in powdered forms), cosmetic colorant. It is classified as a cosmetic ingredient in our database. CAS number: 84775-52-0.

What is the Margin of Safety for Curcuma Longa Root?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Curcuma Longa Root?

The NOAEL (No Observed Adverse Effect Level) for Curcuma Longa Root is 75 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 4 study endpoints are available. Source: COSMOS_DB.

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