NOAEL Studies Cosmetic Ingredient

Cyamopsis Tetragonoloba Gum NOAEL Studies

INCI: CYAMOPSIS TETRAGONOLOBA GUM

CAS: 9000-30-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =0 ppm rat oral 6 weeks developmental toxicity 50; 000; (5, p.21
CIR Safety Assessment NOAEL =1 g/kg/d rat oral 90 days repeated dose toxicity 54; 2; 4, p.17
CIR Safety Assessment NOAEL =1000 mg/kg body weight rat oral - developmental toxicity 50; 000; 12, p.22
COSMOS DB 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 200 mg/kg bw/day monkey oral 180 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 180 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 600 mg/kg bw/day hamster oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 700 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 900 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2500 mg/kg bw/day rat oral 28 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4000 mg/kg bw/day swine oral 8 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5770 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7500 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 11757 mg/kg bw/day rat oral 111 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15000 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =2500 mg/kg bw/day Rat - - chronic/long term toxicity EFSA FEEDAP - 2022 - OutputID 4123 - Safety and efficacy of a feed additive consisting of guar gum for all animal species (A.I.P.G. Association for International Promotion of Gums) - doi:10.2903/j.efsa.2022.7253
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =6770 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11318; row=5457; data_type=In Vivo; mixture=Chemical; chemical_name=Guar gum; preferred_name=alpha-D-Galactopyrano-beta-D-mannopyranan; dtxsid=DTXSID3020675; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020675; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3020675; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =9400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11320; row=5456; data_type=In Vivo; mixture=Chemical; chemical_name=Guar gum; preferred_name=alpha-D-Galactopyrano-beta-D-mannopyranan; dtxsid=DTXSID3020675; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020675; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3020675; source_file=acute_oral.xlsx
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer Top dose 50000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=3447; Record_ID=cancer_4726; Data_Type=In Vivo; Formulation_Name=Guar gum; Mixture=Chemical; DTXSID=DTXSID3020675; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-229; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr229/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020675; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020675
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 0 ppm rat oral 6 weeks developmental toxicity p.21
Regulatory source developmental toxicity 1000 mg/kg body weight rat oral - developmental toxicity p.22
Regulatory source repeated dose toxicity 1 g/kg/d rat oral 90 days repeated dose toxicity p.17
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E89I1637KE UNII - - - structurallyDiverse -