NOAEL Studies Cosmetic Ingredient

Cyclodextrin NOAEL Studies

INCI: CYCLODEXTRIN

CAS: 7585-39-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =466 mg/kg bw/day Dog - 365 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - clinical chemistry - systemic - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =466 mg/kg bw/day Dog - 365 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - clinical chemistry - systemic - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =600 mg/kg bw/day Rat oral: gavage 180 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - body weight - systemic - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =600 mg/kg bw/day Rat oral: gavage 180 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - body weight - systemic - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =654 mg/kg bw/day Rat - 364 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - clinical chemistry - hepatotoxicity - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =654 mg/kg bw/day Rat - 364 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2896 - clinical chemistry - hepatotoxicity - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2016 - OutputID 2896 - Consumers - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2016 - OutputID 2896 - Consumers - Re-evaluation of Beta-cyclodextrin (E 459) as a food additive - doi:10.2903/j.efsa.2016.4628
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11329; row=2031; data_type=In Vivo; mixture=Chemical; chemical_name=beta-Cyclodextrin; preferred_name=beta-Cyclodextrin; dtxsid=DTXSID1020358; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020358; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =18800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11331; row=2030; data_type=In Vivo; mixture=Chemical; chemical_name=beta-Cyclodextrin; preferred_name=beta-Cyclodextrin; dtxsid=DTXSID1020358; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020358; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =1950 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846339_15847685:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0a2bef3bf98e54c995457145d6a900c
ToxValDB_ECHA_IUCLID LOEL =500 mg/kg bw/day Dog oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841077_15841078_15849839_15849840:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab5bcf4a744266e48d45760904478efe
ToxValDB_ECHA_IUCLID LOEL =25000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94ee4b0a7c65d21c4f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/9/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855296_15856139:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e08e390847f59c1b3d7305cdd8d94ae5
ToxValDB_ECHA_IUCLID NOAEL =225 mg/kg bw/day Mouse oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4760; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/8?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817100_15817101_15820207:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ed1ecd9c616357ac7a747e211170062
ToxValDB_ECHA_IUCLID NOAEL =400 mg/kg bw/day Rat oral chronic; 180 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15849843:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5ee1bfce5c63ed4b5285c9d393ea3095
ToxValDB_ECHA_IUCLID NOAEL >=600 mg/kg bw/day Rat oral chronic; 6 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15849837:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a7264b84832381797960c50ecf0f909
ToxValDB_ECHA_IUCLID NOAEL >=675 mg/kg bw/day Mouse oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4760; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/8?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817100_15817101_15820207:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab2f53780413af574cb5c5159a615bf8
ToxValDB_ECHA_IUCLID NOAEL =975 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846339_15847685:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13931455f911b87b47ea94d71d833912
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Dog oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841077_15841078_15849839_15849840:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af8fd880367a21d3a911bebea383ebfd
ToxValDB_ECHA_IUCLID NOAEL >=4160 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15849842:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cdcfc5b1d2a240a6d23cc45803dee716
ToxValDB_ECHA_IUCLID NOAEL =5000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/9/3?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15825154:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0cdae2aaa637b628cffdb99131978c23
ToxValDB_ECHA_IUCLID NOEL =250 mg/kg bw/day Dog oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cb9bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/6/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841077_15841078_15849839_15849840:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_faee23193305dbd5e6c782587831c212
ToxValDB_ECHA_IUCLID NOEL >=600 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/9/3?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15823324:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_018283028d371cf9d4d45715051ec3b3
ToxValDB_ECHA_IUCLID NOEL >=675 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b44b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/8?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820206:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_39333782851544b793d4121099692388
ToxValDB_ECHA_IUCLID NOEL =10000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94ee4b0a7c65d21c4f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1942/7/9/2?documentUUID=4f4a1d67-13e9-476d-b28c-1412086d5a10; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855296_15856139:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b17a7491fa35e8a971c2bb9e83555dae
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =466 mg/kg bw/day Dog oral chronic; 1 years chronic LONG_REF=EFSA ANS (2016). Re-evaluation of Beta-cyclodextrin (E 459) as a food additive. doi:10.2903/j.efsa.2016.4628.; TITLE=Re-evaluation of Beta-cyclodextrin (E 459) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4628; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15624928:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf34225d2f5929be4342525a8cf8524f
ToxValDB_EFSA NOAEL =654 mg/kg bw/day Rat oral chronic; 52 weeks chronic LONG_REF=EFSA ANS (2016). Re-evaluation of Beta-cyclodextrin (E 459) as a food additive. doi:10.2903/j.efsa.2016.4628.; TITLE=Re-evaluation of Beta-cyclodextrin (E 459) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4628; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15624929:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1deb7290af519cf7bffce9234506b908
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier JV039JZZ3A UNII - - - chemical {"approval_status":null,"molecular_formula":"C42H70O35","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JV039JZZ3A"}
openFDA substances FDA UNII substance identifier JV039JZZ3A UNII - - - chemical {"approval_status":null,"molecular_formula":"C42H70O35","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JV039JZZ3A"}
openFDA substances FDA UNII substance identifier JV039JZZ3A UNII - - - chemical {"approval_status":null,"molecular_formula":"C42H70O35","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JV039JZZ3A"}
openFDA substances FDA UNII substance identifier JV039JZZ3A UNII - - - chemical {"approval_status":null,"molecular_formula":"C42H70O35","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JV039JZZ3A"}