Moderate Cosmetic Ingredient

D-Arginyl Tyrosinyl Ornithinyl Phenylalanine

CAS Number
Not clearly assigned as a standalone CAS in public cosmetic databases; described as a Szeto–Schiller–type tetrapeptide analog (D-Arg–Tyr–Orn–Phe–NH₂)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted; used under general FDA cosmetic safety provisions, with manufacturer responsible for establishing safety-in-use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mitochondrial-targeting peptide requiring evaluation of systemic exposure, off-target mitochondrial effects, genotoxicity, and repeat-dose toxicity; restrict to low ppm-range in leave-on products pending comprehensive safety data.

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Concern Level: Moderate

Frequently Asked Questions

Is D-Arginyl Tyrosinyl Ornithinyl Phenylalanine safe in cosmetics?

Mitochondrial-targeting peptide requiring evaluation of systemic exposure, off-target mitochondrial effects, genotoxicity, and repeat-dose toxicity; restrict to low ppm-range in leave-on products pending comprehensive safety data. The EU classifies D-Arginyl Tyrosinyl Ornithinyl Phenylalanine as "permitted". Safety rating: MODERATE.

Is D-Arginyl Tyrosinyl Ornithinyl Phenylalanine allowed in the EU?

D-Arginyl Tyrosinyl Ornithinyl Phenylalanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What is the Margin of Safety for D-Arginyl Tyrosinyl Ornithinyl Phenylalanine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check D-Arginyl Tyrosinyl Ornithinyl Phenylalanine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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