Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dimethyltolylamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOEL | 67.28391 mg/kg bw/day | 1995 | rat | inhalation | REACH |
| LOAEL | 6 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 201.7862 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 20 mg/kg bw/day | oral | mouse | oral | REACH |
| LOAEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 6 mg/kg bw/day | oral | mouse | oral | REACH |
| LOAEL | 62.5 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 30 mg/kg bw/day | oral | mouse | oral | REACH |
| LOAEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 118.934 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CMR Category 1B carcinogenic under CLP Regulation. Prohibited in EU and banned in UK cosmetic regulations.
Regulatory Flags
Frequently Asked Questions
Is Dimethyltolylamine safe in cosmetics?
CMR Category 1B carcinogenic under CLP Regulation. Prohibited in EU and banned in UK cosmetic regulations. The EU classifies Dimethyltolylamine as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Dimethyltolylamine allowed in the EU?
Dimethyltolylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyltolylamine do in cosmetics?
Dimethyltolylamine functions as: Nail product catalyst / accelerator. It is classified as a cosmetic ingredient in our database. CAS number: 99-97-8.
What is the Margin of Safety for Dimethyltolylamine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyltolylamine?
The NOAEL (No Observed Adverse Effect Level) for Dimethyltolylamine is 67.28391 mg/kg bw/day based on a inhalation study via 1995 route in rat. A total of 10 study endpoints are available. Source: REACH.
Is Dimethyltolylamine classified as hazardous under GHS?
Dimethyltolylamine carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful if swallowed or in contact with skin May cause damage to kidneys and liver through prolonged or repeated exposure Suspected of causing cancer Harmful to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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