Moderate Cosmetic Ingredient Sensitization Data Dermal Penetration

D-Dihydrogeraniol

INCI: CITRONELLOL

CAS Number
106-22-9 for Citronellol (the dihydrogeraniol isomer widely used in cosmetics)
Function
Fragrance ingredient with rose-like, floral, and citrusy notes; used in perfumes, skincare, haircare, and personal care products
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 0.001%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Considered GRAS/acceptable as a fragrance component under general safety provisions; no FDA concentration limit identified, but industry follows IFRA standards

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for D-Dihydrogeraniol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.8%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted โ€” max 1.8% in finished products

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of D-Dihydrogeraniol, relevant to systemic exposure and MoS calculations.

Absorption %
16-28%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
156.3 Da
Log P
3.4
Systemic Absorption
yes
Topical Bioavailability
12-24%
Safety Margin Factor
high
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

EU fragrance allergen labeling required; perform sensitization risk assessment for leave-on products, particularly for sensitive-skin or pediatric use; consider using lower fragrance loads or allergen-reduced fragrance where possible

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is D-Dihydrogeraniol safe in cosmetics?

EU fragrance allergen labeling required; perform sensitization risk assessment for leave-on products, particularly for sensitive-skin or pediatric use; consider using lower fragrance loads or allergen-reduced fragrance where possible The EU classifies D-Dihydrogeraniol as "permitted". Safety rating: MODERATE.

Is D-Dihydrogeraniol allowed in the EU?

D-Dihydrogeraniol EU regulatory status: permitted. Maximum allowed concentration: 0.001%. This is based on EU Regulation 1223/2009 and its amendments.

What does D-Dihydrogeraniol do in cosmetics?

D-Dihydrogeraniol functions as: Fragrance ingredient with rose-like, floral, and citrusy notes; used in perfumes, skincare, haircare, and personal care products. It is classified as a cosmetic ingredient in our database. CAS number: 106-22-9 for Citronellol (the dihydrogeraniol isomer widely used in cosmetics).

What is the Margin of Safety for D-Dihydrogeraniol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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