NOAEL Studies Cosmetic Ingredient

D-Panthenol NOAEL Studies

INCI: PANTHENOL

CAS: 81-13-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 % rat oral 29 d repeated dose toxicity 0; 1; 3, p.21
CIR Safety Assessment NOAEL =3 % rat oral 7 d oral toxicity 0; 5; 7, p.45
CIR Safety Assessment NOAEL =20 % mouse oral 653 days NOAEL study 12; 57; 33, p.25
CIR Safety Assessment NOAEL =200 mg/kg/d rat oral 13-wk oral toxicity 200; 500; (100, p.26
CIR Safety Assessment NOAEL =1000 mg/kg/day rat oral 6 D developmental toxicity 6; 0, 500, 750; 1, p.27
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10613; row=5615; data_type=In Vivo; mixture=Chemical; chemical_name=Dexpanthenol; preferred_name=Dexpanthenol; dtxsid=DTXSID3022906; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022906; source_file=acute_oral.xlsx
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =146.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630951:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f7f4844d7657da16d600580dd114a7f
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 % mouse oral 653 days - p.25
Regulatory source developmental toxicity >=1000 mg/kg/day rat oral 6 D developmental toxicity p.27
Regulatory source oral toxicity 3 % rat oral 7 d oral toxicity p.45
Regulatory source oral toxicity 200 mg/kg/d rat oral 13-wk oral toxicity p.26
Regulatory source repeated dose toxicity 1 % rat oral 29 d repeated dose toxicity p.21
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1O6C93RI7Z UNII - - - chemical -