Also known as: (+)-Panthenol, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Cozyme, D-Panthenol 75L, Ilopan (+15 more)
INCI: PANTHENOL
D-Panthenol (CAS 81-13-0) is a cosmetic cosmetic ingredient functioning as Hair and skin conditioning, humectant; provitamin B5. Reported NOAEL =200 mg/kg/d in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 81-13-0 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for D-Panthenol.
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8 study endpoints found for D-Panthenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5
gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5
gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5
gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5
gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >10000 mg/kg | Rat | oral | - | ECHA |
| LD50 | =15000 mg/kg | Mouse | oral | - | ChemIDplus |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Shampoo | 0.1–1 | 2 | CIR Safety Assessment |
| Conditioner | 0.5–2 | 3 | CIR Safety Assessment |
| Face Cream | 0.5–2 | 5 | CIR Safety Assessment |
| Body Lotion | 0.5–2 | 5 | CIR Safety Assessment |
7 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for D-Panthenol.
Public NOAEL study rows linked to D-Panthenol by CAS number or substance name.
Units vary across source rows: mg/kg/d, mg/kg/day
Same-CAS public records found in food safety data.
Same-CAS food additive or FDA GRAS records from the core public database.
D-Panthenol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
D-Panthenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
D-Panthenol functions as: Hair and skin conditioning, humectant; provitamin B5. It is classified as a cosmetic ingredient in our database. CAS number: 81-13-0.
The NOAEL (No Observed Adverse Effect Level) for D-Panthenol is =200 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR Safety Assessment.
D-Panthenol also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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