Excellent Cosmetic Ingredient SCCS/CIR Reviewed

D-Panthenol

INCI: PANTHENOL

CAS Number

81-13-0

Function

Hair and skin conditioning, humectant; provitamin B5

Safety Rating

EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes FDA classifies panthenol as GRAS as a nutrient. Not subject to any FDA cosmetic restriction. Reported in 2017 FDA VCRP at concentrations up to 5.3% leave-on and 5% rinse-off. CIR Expert Panel 2022 issued safe conclusion for panthenol, pantothenic acid, and 5 derivatives at present cosmetic use concentrations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

high

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

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Verdict: safe

NOAEL: 200 mg/kg/day (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

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Verdict: safe

NOAEL: 200 mg/kg/d (oral)

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Verdict: safe

NOAEL: 1 % (oral)

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Verdict: safe

NOAEL: 1 % (not specified)

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Verdict: safe

NOAEL: 1000 mg/kg/d (oral)

Expert Verdict

CAS 81-13-0. EU: Not restricted under EC 1223/2009 Annexes; unrestricted use in cosmetics. US: FDA considers panthenol GRAS as a nutrient; CIR Expert Panel 2022 concluded safe at present use concentrations. Excellent safety profile as provitamin B5 with full conversion to endogenous pantothenic acid. Minor sensitization signal emerging in atopic populations.

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Concern Level: Low

Regulatory Flags

rare-sensitizer rising-allergy-signal eczema-population-caution provitamin-b5 gras widely-used epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is D-Panthenol safe in cosmetics?

Is D-Panthenol allowed in the EU?

D-Panthenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does D-Panthenol do in cosmetics?

D-Panthenol functions as: Hair and skin conditioning, humectant; provitamin B5. It is classified as a Cosmetic Ingredient in our database. CAS number: 81-13-0.

What is the Margin of Safety for D-Panthenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check D-Panthenol compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

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Substance Compliance

Check compliance across 55 jurisdictions

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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