NOAEL Studies Active Ingredient

Dead Sea Salt NOAEL Studies

INCI: MARIS SAL

CAS: 7447-40-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 195 mg/kg bw/day dog oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 235 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 310 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1454 mg/kg bw/day rat oral 854 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1500 mg/kg bw/day rat oral 910 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1551 mg/kg bw/day rat oral 540 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1811 mg/kg bw/day cattle oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2000 mg/kg bw/day sheep oral 1 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2229 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5250 mg/kg bw/day rat oral 105 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL >141.96 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebee4b0a7c65d1cac72; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12089/7/6/2?documentUUID=892c9840-7aea-408c-8610-45e37a4c3025; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15835082:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f53749d3a2bd4f93acf4d6421f7e2384
ECHA NOAEL =310 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea5e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12089/7/9/3?documentUUID=892c9840-7aea-408c-8610-45e37a4c3025; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15821402:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afc7e00eee4ff11a3a0b46b1858af84b
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA LEL =40 mg/kg bw/day Human oral short-term; 4 weeks clinical LONG_REF=EFSA FAF (2019). Re-evaluation of hydrochloric acid (E 507), potassium chloride (E 508), calcium chloride (E 509) and magnesium chloride (E 511) as food additives. doi:10.2903/j.efsa.2019.5751.; TITLE=Re-evaluation of hydrochloric acid (E 507), potassium chloride (E 508), calcium chloride (E 509) and magnesium chloride (E 511) as food additives; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2019.5751; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625467:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e815e2cfaedb0610485e986ddec74c2
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1064 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634243:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_affbff13043c4882fdf9d84028ea2b12
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 660YQ98I10 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"660YQ98I10"}
openFDA substances FDA UNII substance identifier 660YQ98I10 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"660YQ98I10"}
openFDA substances FDA UNII substance identifier 660YQ98I10 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"660YQ98I10"}
openFDA substances FDA UNII substance identifier 660YQ98I10 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"660YQ98I10"}