Good Active Ingredient NOAEL Data GHS Classified

Dead Sea Salt

INCI: MARIS SAL

CAS Number
7447-40-7
Function
Skin Conditioning, Mechanical Exfoliant, Osmotic Agent, Mineral Supplementation (Mg, Ca, K, Br), Anti-inflammatory, Psoriasis Adjuvant Therapy
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; no specific FDA restriction; used in bath products and scrubs; heavy metal limits apply (Washington State TFCA: Pb ≤1 ppm from 2025); MoCRA 2026 compliance required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Dead Sea Salt. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2000 mg/kg bw/day oral sheep Short Term Toxicity COSMOS_DB
NOAEL 5250 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 195 mg/kg bw/day oral dog Short Term Toxicity COSMOS_DB
NOAEL 235 mg/kg bw/day oral mouse Developmental COSMOS_DB
NOAEL 310 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1811 mg/kg bw/day oral cattle Short Term Toxicity COSMOS_DB
NOAEL 1500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 1454 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 2229 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1551 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. Ingestion of large amounts could cause effects on the cardiovascular system. This may result in cardiac dysrhythmia.
Routes of Exposure
The substance can be absorbed into the body by ingestion.

Expert Verdict

Dead Sea Salt (Maris Sal) provides a unique 21-mineral profile (Mg, Ca, K, Br, S being dominant) with documented clinical benefit for psoriasis (5% solution, 6-week controlled trial showing reduced symptoms vs. tap water). Transdermal Mg and K penetration confirmed in controlled mineral varnish study. Functions as a natural mechanical exfoliant and osmotic skin-drawing agent in scrubs and bath salts. Heavy metal testing mandatory with batch Certificate of Analysis required; marine sourcing from the Dead Sea region historically carries low heavy metal contamination risk. Bromine levels should be specified in supplier CoA for final formula compliance review.

⚠️
Concern Level: Low

Regulatory Flags

heavy-metal-testing-required marine-origin psoriasis-clinical-evidence transdermal-mineral-penetration mechanical-exfoliant bromine-content-specify 21-mineral-profile washington-tfca-1ppm-lead-2025 epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Dead Sea Salt safe in cosmetics?

Dead Sea Salt (Maris Sal) provides a unique 21-mineral profile (Mg, Ca, K, Br, S being dominant) with documented clinical benefit for psoriasis (5% solution, 6-week controlled trial showing reduced symptoms vs. tap water). Transdermal Mg and K penetration confirmed in controlled mineral varnish study. Functions as a natural mechanical exfoliant and osmotic skin-drawing agent in scrubs and bath salts. Heavy metal testing mandatory with batch Certificate of Analysis required; marine sourcing from the Dead Sea region historically carries low heavy metal contamination risk. Bromine levels should be specified in supplier CoA for final formula compliance review. The EU classifies Dead Sea Salt as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Dead Sea Salt allowed in the EU?

Dead Sea Salt EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dead Sea Salt do in cosmetics?

Dead Sea Salt functions as: Skin Conditioning, Mechanical Exfoliant, Osmotic Agent, Mineral Supplementation (Mg, Ca, K, Br), Anti-inflammatory, Psoriasis Adjuvant Therapy. It is classified as a Active Ingredient in our database. CAS number: 7447-40-7.

What is the Margin of Safety for Dead Sea Salt?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dead Sea Salt?

The NOAEL (No Observed Adverse Effect Level) for Dead Sea Salt is 2000 mg/kg bw/day based on a Short Term Toxicity study via oral route in sheep. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Dead Sea Salt compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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