NOAEL Studies Cosmetic Ingredient

Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine NOAEL Studies

INCI: DI-T-BUTYL HYDROXYPHENYLAMINO BISOCTYLTHIOTRIAZINE

CAS: 991-84-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa2fe4b0a7c65d1b4bef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/8?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15820274:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_facaecafb9c23eec609c5db02b289bbb
ToxValDB_ECHA_IUCLID NOAEL =3000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c0069; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/9/3?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15825367:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1764311b8c75ff4fff7247271c08da7b
ToxValDB_ECHA_IUCLID NOAEL =818 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1ceacb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/6/2?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850090:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_434989062ba8133bf74f0e66b7ebe802
ToxValDB_ECHA_IUCLID NOAEL =1297.3 mg/kg bw/day Rat oral chronic; 91 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1cead9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/6/2?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850093:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c7730d518f5ba4f53db140ad91bfdb67
ToxValDB_ECHA_IUCLID NOEL =987 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1cead5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/6/2?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850091:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c0ad772a29469efa0046857d8f33ee9
ToxValDB_ECHA_IUCLID NOEL =1010 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1cead5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11227/7/6/2?documentUUID=b39a7be0-0ce8-4b24-9149-0f6be532b184; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850092:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4cc5e1cc384057f374021d77d2bf5057
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631027_15631028:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2be7253da6371e40a9bb0e7a45ac9d1b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier O1Q826IX7H UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H56N4OS2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O1Q826IX7H"}
openFDA substances FDA UNII substance identifier O1Q826IX7H UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H56N4OS2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O1Q826IX7H"}
openFDA substances FDA UNII substance identifier O1Q826IX7H UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H56N4OS2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O1Q826IX7H"}
openFDA substances FDA UNII substance identifier O1Q826IX7H UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H56N4OS2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O1Q826IX7H"}