Also known as: 2,4-Bis(octylthio)-6-(4-hydroxy-3,5-di-tert-butylanilino)-1,3,5-triazine, EINECS 213-590-1, Irganox 565, Irganox RA 565, NSC 328455 (+1 more)
INCI: DI-T-BUTYL HYDROXYPHENYLAMINO BISOCTYLTHIOTRIAZINE
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine (CAS 991-84-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, UV stabilizer. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 991-84-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine.
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4 study endpoints found for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =818 mg/kg bw/day | oral | Dog | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1297.3 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =3000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine.
Public NOAEL study rows linked to Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine by CAS number or substance name.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine functions as: Antioxidant, UV stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 991-84-4.
The NOAEL (No Observed Adverse Effect Level) for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine is =200 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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