Also known as: 2,4-Bis(octylthio)-6-(4-hydroxy-3,5-di-tert-butylanilino)-1,3,5-triazine, EINECS 213-590-1, Irganox 565, Irganox RA 565, NSC 328455 (+1 more)
INCI: DI-T-BUTYL HYDROXYPHENYLAMINO BISOCTYLTHIOTRIAZINE
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine (CAS 991-84-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, UV stabilizer. Reported NOAEL =200 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine.
Calculate MoS for your specific formulation with the MoS Calculator.
4 study endpoints found for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =818 mg/kg bw/day | oral | Dog | subchronic | ECHA |
| NOAEL | =1297.3 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =3000 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine by CAS number or substance name.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine functions as: Antioxidant, UV stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 991-84-4.
The NOAEL (No Observed Adverse Effect Level) for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine is =200 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 4 study endpoints are available. Source: ECHA.
Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Check Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine in your formulation.