NOAEL Studies Cosmetic Ingredient

DI-T-BUTYLHYDROQUINONE NOAEL Studies

CAS: 88-58-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 117 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3371; Record_ID=adme_parameters_749; Data_Type=Measured; DTXSID=DTXSID8041248; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=117.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
NTP_ICE_adme_parameters Fu 1.83e-7 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3370; Record_ID=adme_parameters_749; Data_Type=Measured; DTXSID=DTXSID8041248; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.83e-07; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 34.8079919974549 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1984; RecordID=ARPathway2016_306; DatasetName=ARPathway2016; DTXSID=DTXSID8041248; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=34.8079919974549; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
NTP_ICE_endocrine ACC 39.5813543500983 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1985; RecordID=ARPathway2016_306; DatasetName=ARPathway2016; DTXSID=DTXSID8041248; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=39.5813543500983; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
NTP_ICE_endocrine Model Score 0.0413 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1986; RecordID=ARPathway2016_306; DatasetName=ARPathway2016; DTXSID=DTXSID8041248; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0413; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1987; RecordID=ARPathway2016_306; DatasetName=ARPathway2016; DTXSID=DTXSID8041248; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041248
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf40e4b0a7c65d1cd380; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24124/7/6/2?documentUUID=52e77b2a-f248-4f1e-9a82-b967d8f8bc3c; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ECHA IUCLID:15840808:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b0d8a63f20ddaacc20180b44a5b91ac
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.822 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631756:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d643331ee3bbfb8956eb2175ba689f99
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 26XK13B61B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"26XK13B61B"}
openFDA substances FDA UNII substance identifier 26XK13B61B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"26XK13B61B"}
openFDA substances FDA UNII substance identifier 26XK13B61B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"26XK13B61B"}
openFDA substances FDA UNII substance identifier 26XK13B61B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"26XK13B61B"}