NOAEL Studies Cosmetic Ingredient

Diammonium Phosphate NOAEL Studies

INCI: DIAMMONIUM PHOSPHATE

CAS: 7783-28-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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INCHEM_WHO_jecfa_jecmono_v1007je01 54 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-0.30.3 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=0a5d8a235416e74c; raw_unit=mg/kg bw per day; context=At the fourteenth meeting, a temporary ADI of 0-0.6 mg/kg bw per day was established for tannins derived from Peruvian tara, and a temporary ADI of 0-0.3 mg/kg bw per day was established for tannins derived from Turkish Aleppo, Chinese tara and Sicilian sumac.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-0.30.3 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=0a5d8a235416e74c; raw_unit=mg/kg bw per day; context=At the fourteenth meeting, a temporary ADI of 0-0.6 mg/kg bw per day was established for tannins derived from Peruvian tara, and a temporary ADI of 0-0.3 mg/kg bw per day was established for tannins derived from Turkish Aleppo, Chinese tara and Sicilian sumac.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-0.60.6 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=63bf0d17b85a0444; raw_unit=mg/kg bw per day; context=At the fourteenth meeting, a temporary ADI of 0-0.6 mg/kg bw per day was established for tannins derived from Peruvian tara, and a temporary ADI of 0-0.3 mg/kg bw per day was established for tannins derived from Turkish Aleppo, Chinese tara and Sicilian sumac.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-0.60.6 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=63bf0d17b85a0444; raw_unit=mg/kg bw per day; context=At the fourteenth meeting, a temporary ADI of 0-0.6 mg/kg bw per day was established for tannins derived from Peruvian tara, and a temporary ADI of 0-0.3 mg/kg bw per day was established for tannins derived from Turkish Aleppo, Chinese tara and Sicilian sumac.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-1.51.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=20e1053a3eb1bccc; raw_unit=mg/kg bw; context=An ADI of 0-1.5 mg/kg bw was allocated at the 79th JECFA (2014).
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-1.51.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=20e1053a3eb1bccc; raw_unit=mg/kg bw; context=An ADI of 0-1.5 mg/kg bw was allocated at the 79th JECFA (2014).
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=215fb73cd7e0997c; raw_unit=mg/kg bw; context=Anthocyanins were evaluated by the Committee at its twenty-sixth meeting, when an ADI of 0-2.5 mg/kg bw was established (Annex 1, reference 59).
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=215fb73cd7e0997c; raw_unit=mg/kg bw; context=Anthocyanins were evaluated by the Committee at its twenty-sixth meeting, when an ADI of 0-2.5 mg/kg bw was established (Annex 1, reference 59).
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-55 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=d942d52b1dc2569a; raw_unit=mg/kg bw; context=At the thirty-first meeting, the Committee concluded that the group ADI of 0-5 mg/kg bw established for the sum of the synthetic carotenoids β-carotene, β-apo-8′-carotenal and β-apo-8′-carotenoic acid methyl and ethyl esters by the eighteenth Committee was not applicable to natural carotenes as they did not comply with the specifications for β-c
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-55 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=d942d52b1dc2569a; raw_unit=mg/kg bw; context=At the thirty-first meeting, the Committee concluded that the group ADI of 0-5 mg/kg bw established for the sum of the synthetic carotenoids β-carotene, β-apo-8′-carotenal and β-apo-8′-carotenoic acid methyl and ethyl esters by the eighteenth Committee was not applicable to natural carotenes as they did not comply with the specifications for β-c
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-66 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=cba3256bdff055cb; raw_unit=mg/kg bw; context=The Committee established an ADI of 0-6 mg/kg bw based on this NOAEL by applying an uncertainty factor of 100 for interspecies and intraspecies differences.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-66 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=cba3256bdff055cb; raw_unit=mg/kg bw; context=The Committee established an ADI of 0-6 mg/kg bw based on this NOAEL by applying an uncertainty factor of 100 for interspecies and intraspecies differences.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI =12 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=18900ef71cd3bfa8; raw_unit=mg/kg bw per day; context=The Committee noted that the conservative dietary exposure estimate for Fast Green FCF of 12 mg/kg bw per day (95th percentile for adolescents) was below the upper bound of the ADI.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI =12 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=18900ef71cd3bfa8; raw_unit=mg/kg bw per day; context=The Committee noted that the conservative dietary exposure estimate for Fast Green FCF of 12 mg/kg bw per day (95th percentile for adolescents) was below the upper bound of the ADI.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-12.512.5 mg/kg bw/day Rat oral 2-year Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=eecade6577f1bfe6; raw_unit=mg/kg bw; context=17 Joint FAO/WHO Expert Committee on Food Additives Eighty-fourth report In its previous evaluation at the thirteenth meeting (Annex 1, reference 19), the Committee established an ADI of 0-12.5 mg/kg bw based on a 2-year toxicity study in which male and female rats were fed a diet containing 0%, 0.5%, 1.0%, 2.0% or 5.0% Brilliant Blue FCF.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-12.512.5 mg/kg bw/day Rat oral 2-year Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=eecade6577f1bfe6; raw_unit=mg/kg bw; context=17 Joint FAO/WHO Expert Committee on Food Additives Eighty-fourth report In its previous evaluation at the thirteenth meeting (Annex 1, reference 19), the Committee established an ADI of 0-12.5 mg/kg bw based on a 2-year toxicity study in which male and female rats were fed a diet containing 0%, 0.5%, 1.0%, 2.0% or 5.0% Brilliant Blue FCF.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-2525 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=67659f305cb377a9; raw_unit=mg/kg bw; context=eth meeting, the Committee reviewed histopathological data from the rat oral carcinogenicity study and concluded that Fast Green FCF was noncarcinogenic in rats and established an ADI of 0-25 mg/kg bw, based on a long-term study of toxicity in rats.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-2525 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=67659f305cb377a9; raw_unit=mg/kg bw; context=eth meeting, the Committee reviewed histopathological data from the rat oral carcinogenicity study and concluded that Fast Green FCF was noncarcinogenic in rats and established an ADI of 0-25 mg/kg bw, based on a long-term study of toxicity in rats.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-3030 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=32252a6f5914dff1; raw_unit=mg/kg bw; context=At its seventeenth meeting, the Committee established a group ADI of 0-30 mg/kg bw for L(+)-tartaric acid and its sodium, potassium and potassium-sodium salts, expressed as L(+)-tartaric acid.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI range:0-3030 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=32252a6f5914dff1; raw_unit=mg/kg bw; context=At its seventeenth meeting, the Committee established a group ADI of 0-30 mg/kg bw for L(+)-tartaric acid and its sodium, potassium and potassium-sodium salts, expressed as L(+)-tartaric acid.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI =100 mg/L - oral - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=22e1b68f1694b58e; raw_unit=mg/L; context=The Committee noted that the dietary exposure estimate for metatartaric acid for adult consumers of wine was 4% of the upper bound of the ADI and concluded that dietary exposure to metatartaric acid in wine at the maximum use level of 100 mg/L does not present a health concern.
INCHEM_WHO_jecfa_jecmono_v1007je01 ADI =100 mg/L - oral - Health guidance value document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=22e1b68f1694b58e; raw_unit=mg/L; context=The Committee noted that the dietary exposure estimate for metatartaric acid for adult consumers of wine was 4% of the upper bound of the ADI and concluded that dietary exposure to metatartaric acid in wine at the maximum use level of 100 mg/L does not present a health concern.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =50 mg/kg bw/day Human; Rat oral - Reproductive toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=9aee2de99245a57e; raw_unit=mg/kg bw per day; context=The group ADI (0-5 mg/kg bw) was derived using a four-generation study in rats with a NOAEL for β-carotene of 50 mg/kg bw per day with application of a safety factor of 10 because of the natural occurrence of carotenoids in the human diet and the low toxicity observed in animal studies.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =50 mg/kg bw/day Human; Rat oral - Reproductive toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=9aee2de99245a57e; raw_unit=mg/kg bw per day; context=The group ADI (0-5 mg/kg bw) was derived using a four-generation study in rats with a NOAEL for β-carotene of 50 mg/kg bw per day with application of a safety factor of 10 because of the natural occurrence of carotenoids in the human diet and the low toxicity observed in animal studies.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =200 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=e6c211a8520d3abe; raw_unit=mg/kg bw per day; context=The NOAEL was 0.15% (equivalent to 200 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =200 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=e6c211a8520d3abe; raw_unit=mg/kg bw per day; context=The NOAEL was 0.15% (equivalent to 200 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL ~330 mg/kg bw/day Rat; Dog oral 90-day Subchronic toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=8c440b95dfd61a9d; raw_unit=mg/kg bw per day; context=A comparison of the dietary exposure estimate (11 mg/kg bw per day) with the NOAEL from the 90-day studies of oral toxicity in rats and dogs (approximately 330 mg/kg bw per day) gives a margin of exposure of approximately 30.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL ~330 mg/kg bw/day Rat; Dog oral 90-day Subchronic toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=8c440b95dfd61a9d; raw_unit=mg/kg bw per day; context=A comparison of the dietary exposure estimate (11 mg/kg bw per day) with the NOAEL from the 90-day studies of oral toxicity in rats and dogs (approximately 330 mg/kg bw per day) gives a margin of exposure of approximately 30.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =631 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=6d062bc37864bfa4; raw_unit=mg/kg bw per day; context=The NOAEL was 1% (equal to 631 mg/kg bw per day), based on 15% decreased mean terminal body weight and decreased survival of female rats at the highest dose level (IRDC, 1981b;
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =631 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=6d062bc37864bfa4; raw_unit=mg/kg bw per day; context=The NOAEL was 1% (equal to 631 mg/kg bw per day), based on 15% decreased mean terminal body weight and decreased survival of female rats at the highest dose level (IRDC, 1981b;
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =647 mg/kg bw/day Rat - - Developmental toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=ce6ec77d8e859608; raw_unit=mg/kg bw per day; context=Based on the combined fertility and developmental toxicity study in rats (Collins et al., 1987), an overall NOAEL of 10 647 mg/kg bw per day (the highest dose tested) was identified for reproductive, developmental and parental effects.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =647 mg/kg bw/day Rat - - Developmental toxicity document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=ce6ec77d8e859608; raw_unit=mg/kg bw per day; context=Based on the combined fertility and developmental toxicity study in rats (Collins et al., 1987), an overall NOAEL of 10 647 mg/kg bw per day (the highest dose tested) was identified for reproductive, developmental and parental effects.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL range:636-11131113 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=629c6f4bdde754c9; raw_unit=mg/kg bw per day; context=Correction of the dose used to derive the NOAEL for D. salina d-limonene extract of 3180 mg/kg bw per day for the percentage of the algal component (20-35%) gives an adjusted NOAEL of 636-1113 mg/kg bw per day for the algal lipid component of the test substance.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL range:636-11131113 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=629c6f4bdde754c9; raw_unit=mg/kg bw per day; context=Correction of the dose used to derive the NOAEL for D. salina d-limonene extract of 3180 mg/kg bw per day for the percentage of the algal component (20-35%) gives an adjusted NOAEL of 636-1113 mg/kg bw per day for the algal lipid component of the test substance.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=cceec9f8863d048e; raw_unit=mg/kg bw per day; context=The NOAEL was 5.0% (equivalent to 2500 mg/kg bw per day), the highest concentration tested (Hansen et al., 1966).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=cceec9f8863d048e; raw_unit=mg/kg bw per day; context=The NOAEL was 5.0% (equivalent to 2500 mg/kg bw per day), the highest concentration tested (Hansen et al., 1966).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2680 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=c9aec03fb8b66c88; raw_unit=mg/kg bw per day; context=The Committee concluded that the NOAEL for L(+)-tartaric acid in the study was 2680 mg/kg bw per day, the highest tested dose.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2680 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=c9aec03fb8b66c88; raw_unit=mg/kg bw per day; context=The Committee concluded that the NOAEL for L(+)-tartaric acid in the study was 2680 mg/kg bw per day, the highest tested dose.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2750 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=978a2941bbef6b40; raw_unit=mg/kg bw per day; context=The Committee concluded that the NOAEL was 5% (2750 mg/kg bw per day) of Dunaliella extract, the highest concentration tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =2750 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=978a2941bbef6b40; raw_unit=mg/kg bw per day; context=The Committee concluded that the NOAEL was 5% (2750 mg/kg bw per day) of Dunaliella extract, the highest concentration tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3000 mg/kg bw/day Rat; Mouse oral - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=6f9cad95ae7a94ec; raw_unit=mg/kg bw per day; context=The NOAEL was 2% Fast Green FCF in the diet (equivalent to 3000 mg/kg bw per day) in mice and 5.0% (equivalent to 2500 mg/kg bw per day) in rats (Hansen et al., 1966).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3000 mg/kg bw/day Rat; Mouse oral - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=6f9cad95ae7a94ec; raw_unit=mg/kg bw per day; context=The NOAEL was 2% Fast Green FCF in the diet (equivalent to 3000 mg/kg bw per day) in mice and 5.0% (equivalent to 2500 mg/kg bw per day) in rats (Hansen et al., 1966).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3044 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=2c58e50b1211bd0a; raw_unit=mg/kg bw per day; context=Davis, 2012), the Committee identified a NOAEL of 3044 mg/kg bw per day (equal to 2590 mg/kg bw per day, corrected for purity), the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3044 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=2c58e50b1211bd0a; raw_unit=mg/kg bw per day; context=Davis, 2012), the Committee identified a NOAEL of 3044 mg/kg bw per day (equal to 2590 mg/kg bw per day, corrected for purity), the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3180 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=30d1a7c174238a55; raw_unit=mg/kg bw per day; context=The Committee concluded that the findings in the fundus were most likely due to a local effect of the high concentration of the test material given as a bolus, and identified the NOAEL to be 3180 mg/kg bw per day of D. salina d-limonene extract, the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3180 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=30d1a7c174238a55; raw_unit=mg/kg bw per day; context=The Committee concluded that the findings in the fundus were most likely due to a local effect of the high concentration of the test material given as a bolus, and identified the NOAEL to be 3180 mg/kg bw per day of D. salina d-limonene extract, the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3184 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=e8ad5b6d6cde8ce2; raw_unit=mg/kg bw per day; context=The previous Committee agreed with this conclusion at its thirtieth meeting and concluded that the NOAEL in this dietary study was 5% Fast Green FCF (equal to 3184 mg/kg bw per day), the highest dose tested (Annex 1, reference 73).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3184 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=e8ad5b6d6cde8ce2; raw_unit=mg/kg bw per day; context=The previous Committee agreed with this conclusion at its thirtieth meeting and concluded that the NOAEL in this dietary study was 5% Fast Green FCF (equal to 3184 mg/kg bw per day), the highest dose tested (Annex 1, reference 73).
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3392 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=51e3f143e550edb5; raw_unit=mg/kg bw per day; context=The Committee considered this decrease in body weights to be a treatment-related adverse effect and concluded that the NOAEL was 1.5% Fast Green FCF (equal to 3392 mg/kg bw per day), based on the lower body weights observed at 5% (equal to 11 805 mg/kg bw per day) in females.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =3392 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=51e3f143e550edb5; raw_unit=mg/kg bw per day; context=The Committee considered this decrease in body weights to be a treatment-related adverse effect and concluded that the NOAEL was 1.5% Fast Green FCF (equal to 3392 mg/kg bw per day), based on the lower body weights observed at 5% (equal to 11 805 mg/kg bw per day) in females.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =5150 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=226f8a7ba28a3696; raw_unit=mg/kg bw per day; context=The NOAEL was 5150 mg/kg bw per day (corrected to 4161 mg/kg bw per day for purity), the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =5150 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=226f8a7ba28a3696; raw_unit=mg/kg bw per day; context=The NOAEL was 5150 mg/kg bw per day (corrected to 4161 mg/kg bw per day for purity), the highest dose tested.
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =7354 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=7dc09a50c5d34c33; raw_unit=mg/kg bw per day; context=ietary concentrations of 0%, 0.5%, 1.5% or 5% (equal to 0, 661, 2064 and 7354 mg/kg bw per day for males and 0, 819, 2562 and 8966 mg/kg bw per day for females, respectively), the NOAEL was 5% (equal to 7354 mg/kg bw per day), the highest concentration tested (IRDC, 1981a;
INCHEM_WHO_jecfa_jecmono_v1007je01 NOAEL =7354 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v1007je01; title=W H O T e c h n i c a l R e p o r t S e r i e s Evaluation of certain food additives Eighty-fourth report of the Joint FAO/WHO Expert Committee on Food Additive; path=mirror/documents/jecfa/jecmono/v1007je01.pdf; row_hash=7dc09a50c5d34c33; raw_unit=mg/kg bw per day; context=ietary concentrations of 0%, 0.5%, 1.5% or 5% (equal to 0, 661, 2064 and 7354 mg/kg bw per day for males and 0, 819, 2562 and 8966 mg/kg bw per day for females, respectively), the NOAEL was 5% (equal to 7354 mg/kg bw per day), the highest concentration tested (IRDC, 1981a;
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=1500 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc309; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16400/7/9/3?documentUUID=5a17a06f-6d34-4eb3-bee6-df1f4bdd841f; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821422:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0735c279f8dff1322935e22c61e3cb6
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630998:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba75bd9a9cb95685752195330bc2e805
ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) BMDL (10 HED) =27.7 mg/kg bw/day Rat oral - subchronic LONG_REF=Huntingdon (2002) as cited in OECD (2007b) and ECHA (2002); AUTHOR=Huntingdon; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1668; TOXICOLOGICAL_EFFECT=Submucosal inflammation in stomach; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=PPRTV (CPHEA):15653914:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bf2e5f671e5886a5e0a141e0bd4b6400
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =0.09 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Huntingdon (2002) as cited in OECD (2007b) and ECHA (2002); AUTHOR=Huntingdon; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1668; TOXICOLOGICAL_EFFECT=Submucosal inflammation in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653609:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1f7226ee0844fea7b74e104398afd818
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 10LGE70FSU UNII - - - chemical {"approval_status":null,"molecular_formula":"HO4P.2H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"10LGE70FSU"}
openFDA substances FDA UNII substance identifier 10LGE70FSU UNII - - - chemical {"approval_status":null,"molecular_formula":"HO4P.2H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"10LGE70FSU"}
openFDA substances FDA UNII substance identifier 10LGE70FSU UNII - - - chemical {"approval_status":null,"molecular_formula":"HO4P.2H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"10LGE70FSU"}
openFDA substances FDA UNII substance identifier 10LGE70FSU UNII - - - chemical {"approval_status":null,"molecular_formula":"HO4P.2H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"10LGE70FSU"}