NOAEL Studies Preservative

Diazolidinyl Urea NOAEL Studies

INCI: DIAZOLIDINYL UREA

CAS: 78491-02-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =0.1 - rat oral 29 consecutive days NOAEL study {"page":6,"pdf":"pr137.pdf","row_type":"noael_study","study_id":"beta_noael_1"}
CIR_vision_codex NOAEL =0.1 - rat oral 29 consecutive days NOAEL study {"page":6,"pdf":"pr137.pdf","row_type":"noael_study","study_id":"beta_noael_1"}
CIR_vision_codex NOAEL =0.1 - rat oral 29 consecutive days NOAEL study {"page":6,"pdf":"pr137.pdf","row_type":"noael_study","study_id":"beta_noael_1"}
CIR_vision_codex NOAEL =0.1 - rat oral 29 consecutive days NOAEL study {"page":6,"pdf":"pr137.pdf","row_type":"noael_study","study_id":"beta_noael_1"}
NTP_ICE_acute_oral 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10389; row=918; data_type=In Vivo; mixture=Chemical; chemical_name=Diazolidinyl urea; preferred_name=Diazolidinyl urea; dtxsid=DTXSID0029559; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10391; row=919; data_type=In Vivo; mixture=Chemical; chemical_name=Diazolidinyl urea; preferred_name=Diazolidinyl urea; dtxsid=DTXSID0029559; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10393; row=920; data_type=In Vivo; mixture=Chemical; chemical_name=Diazolidinyl urea; preferred_name=Diazolidinyl urea; dtxsid=DTXSID0029559; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10373; row=921; data_type=In Vivo; mixture=Chemical; chemical_name=Diazolidinyl urea; preferred_name=Diazolidinyl urea; dtxsid=DTXSID0029559; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10374; row=917; data_type=In Vivo; mixture=Chemical; chemical_name=Diazolidinyl urea; preferred_name=Diazolidinyl urea; dtxsid=DTXSID0029559; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559; source_file=acute_oral.xlsx
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 0.114738155735841 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7599; RecordID=ARPathway2016_385; DatasetName=ARPathway2016; DTXSID=DTXSID0029559; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=0.114738155735841; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559
NTP_ICE_endocrine ACC 0.00272867851285823 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7598; RecordID=ARPathway2016_385; DatasetName=ARPathway2016; DTXSID=DTXSID0029559; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=0.00272867851285823; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7600; RecordID=ARPathway2016_385; DatasetName=ARPathway2016; DTXSID=DTXSID0029559; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559
NTP_ICE_endocrine Model Score 0.251 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7601; RecordID=ARPathway2016_385; DatasetName=ARPathway2016; DTXSID=DTXSID0029559; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.251; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029559
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =1600 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d22802f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/6/2?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15841722:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bcb69373d3a4999bac76030256ab3b99
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc2ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/6/2?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15849893:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db748eb7e44be3ce53a01fd25f4f551d
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat dermal - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d231f0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/9/3?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15821282:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7e5c336b4900d42f27f415d7d1ae33d
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf186; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/9/3?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15825205:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a07a990cc339bf9a062bf6f6489525b
ToxValDB_ECHA_IUCLID NOEL =200 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc2d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/6/2?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15847877:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d7cd439d072de16339a158d31b3a3704
ToxValDB_ECHA_IUCLID NOEL =250 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc2c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/6/2?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15849895:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7eaa29a60a75ac6bdb7bc9f83c8eaf15
ToxValDB_ECHA_IUCLID NOEL =300 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc2b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10662/7/6/2?documentUUID=d9a13d1f-9f7d-4313-a23a-284d388d2148; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15849894:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3821c9e939901b39538afa63ac2600da
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =20.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630221:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f120194a8e8492a69b3946d39c3d22d3
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H5RIZ3MPW4 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H5RIZ3MPW4"}
openFDA substances FDA UNII substance identifier H5RIZ3MPW4 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H5RIZ3MPW4"}
openFDA substances FDA UNII substance identifier H5RIZ3MPW4 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H5RIZ3MPW4"}
openFDA substances FDA UNII substance identifier H5RIZ3MPW4 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H5RIZ3MPW4"}
openFDA substances FDA UNII substance identifier N9VX1IBW6K UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14N4O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9VX1IBW6K"}
openFDA substances FDA UNII substance identifier N9VX1IBW6K UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14N4O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9VX1IBW6K"}
openFDA substances FDA UNII substance identifier N9VX1IBW6K UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14N4O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9VX1IBW6K"}
openFDA substances FDA UNII substance identifier N9VX1IBW6K UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14N4O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9VX1IBW6K"}