NOAEL Studies Cosmetic Ingredient

Dibutoxymethane NOAEL Studies

INCI: DIBUTOXYMETHANE

CAS: 2568-90-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd222; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7910/7/9/3?documentUUID=4760ae91-4de8-4ebe-8dd8-ad2550a595d2; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: necropsy findings|maternal: organ weights and organ / body weight ratios|maternal: pre and post implantation loss|maternal: total litter losses by resorption|maternal: changes in number of pregnant|maternal: clinical signs|maternal: dead fetuses|maternal: early or late resorptions|maternal: food consumption and compound intake|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: maternal abnormalities|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|development|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15824664:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8632d9fa8352835ab0a18f3fea3bed6
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6b09; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7910/7/6/2?documentUUID=4760ae91-4de8-4ebe-8dd8-ad2550a595d2; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15849340:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_291cc2625dc9218700dbdf0349c9fd7b
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaadfe4b0a7c65d1b7cbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7910/7/9/2?documentUUID=4760ae91-4de8-4ebe-8dd8-ad2550a595d2; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15861040:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d2d829dca4a28cd34bd0703cd5f79648
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaadfe4b0a7c65d1b7cbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7910/7/9/2?documentUUID=4760ae91-4de8-4ebe-8dd8-ad2550a595d2; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15861904:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_165a23307fd827ef37d1b0e5a8840ec6
ToxValDB_ECHA_IUCLID NOEL ~13109 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7910/7/6/3?documentUUID=4760ae91-4de8-4ebe-8dd8-ad2550a595d2; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=ECHA IUCLID:15828900:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdfff79659b82ab6e110c6b913fc9745
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =126.63 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632329:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f245311a5af68e86888ec2bed2aa3a50
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier V5WWR58LDU UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5WWR58LDU"}
openFDA substances FDA UNII substance identifier V5WWR58LDU UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5WWR58LDU"}
openFDA substances FDA UNII substance identifier V5WWR58LDU UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5WWR58LDU"}
openFDA substances FDA UNII substance identifier V5WWR58LDU UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5WWR58LDU"}