Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dibutoxymethane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | ca.2000 2285 | 1995 | rat | inhalation | REACH |
Expert Verdict
Acetal (dibutyl formal) that may hydrolyze under acidic conditions releasing butanol and formaldehyde; formaldehyde release potential must be verified; limited published cosmetic safety reviews and supplier toxicology data required for CPSR.
Regulatory Flags
Frequently Asked Questions
Is Dibutoxymethane safe in cosmetics?
Acetal (dibutyl formal) that may hydrolyze under acidic conditions releasing butanol and formaldehyde; formaldehyde release potential must be verified; limited published cosmetic safety reviews and supplier toxicology data required for CPSR. The EU classifies Dibutoxymethane as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Dibutoxymethane allowed in the EU?
Dibutoxymethane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutoxymethane do in cosmetics?
Dibutoxymethane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 2568-90-3.
What is the Margin of Safety for Dibutoxymethane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibutoxymethane?
The NOAEL (No Observed Adverse Effect Level) for Dibutoxymethane is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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