Is Dibutoxymethane safe in cosmetics?
Dibutoxymethane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Dibutoxymethane
Also known as: Butylal, Di-n-butoxymethane, Dibutyl formal, Di-n-butyl formal, EINECS 219-909-0 (+3 more)
INCI: DIBUTOXYMETHANE
Dibutoxymethane (CAS 2568-90-3) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2568-90-3 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(butoxymethoxy)butane
InChIKey
QLCJOAMJPCOIDI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibutoxymethane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Dibutoxymethane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dibutoxymethane across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Emulsifier
Fragrance
Solvent
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Dibutoxymethane.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dibutoxymethane by CAS number or substance name.
Studies
4
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Butylal
Di-n-butoxymethane
Dibutyl formal
Di-n-butyl formal
EINECS 219-909-0
Formaldehyde dibutyl acetal
NSC 241
UNII-V5WWR58LDU
Chemical Function
Solvent
Emulsifier
Cleaning agent
Fragrance
Regulatory Lists
IFRA Transparency
drinking_water; Europe; manufacturing; plastic_additive
drinking_water; Europe; manufacturing; plastic_additive
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dibutoxymethane allowed in the EU?
Dibutoxymethane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutoxymethane do in cosmetics?
Dibutoxymethane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 2568-90-3.
What is the NOAEL for Dibutoxymethane?
The NOAEL (No Observed Adverse Effect Level) for Dibutoxymethane is =300 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Dibutoxymethane used outside cosmetics?
Dibutoxymethane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dibutoxymethane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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BENZALDEHYDE PROPYLENEGLYCOL ACETAL
Good
Chemical family
Perfuming
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