NOAEL Studies Cosmetic Ingredient

Dibutyl Adipate NOAEL Studies

INCI: DIBUTYL ADIPATE

CAS: 105-99-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 14.03 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=846; Record_ID=adme_parameters_247; Data_Type=Measured; DTXSID=DTXSID2021866; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=14.03; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021866
NTP_ICE_adme_parameters Fu 0.5872 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=845; Record_ID=adme_parameters_247; Data_Type=Measured; DTXSID=DTXSID2021866; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.5872; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021866
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7658; RecordID=ARPathway2016_463; DatasetName=ARPathway2016; DTXSID=DTXSID2021866; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021866
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier F4K100DXP3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F4K100DXP3"}
openFDA substances FDA UNII substance identifier F4K100DXP3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F4K100DXP3"}
openFDA substances FDA UNII substance identifier F4K100DXP3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F4K100DXP3"}
openFDA substances FDA UNII substance identifier F4K100DXP3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F4K100DXP3"}