NOAEL Studies Cosmetic Ingredient

Dibutyl Sebacate NOAEL Studies

INCI: DIBUTYL SEBACATE

CAS: 109-43-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 625 mg/kg bw/day rat oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3125 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 134 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=666; Record_ID=adme_parameters_967; Data_Type=Measured; DTXSID=DTXSID1041847; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=134.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1041847
NTP_ICE_adme_parameters Fu 7.05e-8 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=667; Record_ID=adme_parameters_967; Data_Type=Measured; DTXSID=DTXSID1041847; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=7.05e-08; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1041847
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7674; RecordID=ARPathway2016_527; DatasetName=ARPathway2016; DTXSID=DTXSID1041847; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1041847
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4W5IH7FLNY UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H34O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4W5IH7FLNY"}
openFDA substances FDA UNII substance identifier 4W5IH7FLNY UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H34O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4W5IH7FLNY"}
openFDA substances FDA UNII substance identifier 4W5IH7FLNY UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H34O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4W5IH7FLNY"}
openFDA substances FDA UNII substance identifier 4W5IH7FLNY UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H34O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4W5IH7FLNY"}